Stefanus Gunawan
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Febrile neutropenia in childhood leukemia: Manado experience 1997 - 2006 Stefanus Gunawan; Novie Homenta Rampengan; Max Frans Joseph Mantik; Tonny Homenta Rampengan
Paediatrica Indonesiana Vol 49 No 6 (2009): November 2009
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (119.43 KB) | DOI: 10.14238/pi49.6.2009.372-8

Abstract

Background Febrile neutropenia (FNP) is a common complicationof therapy among children with cancer. It is one of the causes ofsignificant morbidity and mortality in children and young adultstreated for cancer. With aggressive management of FNP, theoutcome of episodes in children has improved dramatically.Objective To determine factors associated with FNP, to assess how varied the current management, and to evaluate the outcome of FNP in childhood leukemia in Manado over the last 10 years.Methods Data from medical records was collected retrospectivelyfrom January 1997 to December 2006. Variables studied were: age, sex, nutritional status, sosio-economic status, type of leukemia, degree of fever, ANC at fever, phase of chemotherapy, antibiotic used, episodes ofFNP and the outcome of patients.Results Twenty of ninety one patients were studied. The mortality rate was crucial i.e., 11 of20, it was higher in boys than that in girls. Most children have severe to very severe neutropenia and more than half died (7 /13). Seven out of 12 malnourished patients died. Sixteen children are suffered from acute lymphoblastic leukemia (ALL). The outcome of high risk (HR) patients was worse than that of standard risk (SR). FNP occurred along the phase of chemotherapy. None of the factors studied showed significant difference. The choice of antibiotics is varied.Conclusion The outcome of FNP in our institution is grave.There is a need to evaluate application and compliance to thestandard guidelines.
The association between nutritional status and motor development in children under five years old Nurhayati Masloman; Stefanus Gunawan
Paediatrica Indonesiana Vol 45 No 3 (2005): May 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.3.2005.107-10

Abstract

Background Severe malnutrition in children is closely related todelayed physical growth and mental development. Very few re-ports mention the effects of mild to moderate malnutrition on mo-tor development.Objective The objective of this study was to determine the rela-tionship between nutritional status and motor development in earlychildhood.Methods In this cross-sectional study, we examined body weightof children under 5 years of age, the ability to sit or walk withoutsupport, and parachute sign in those under 2 years of age whocame to community child health surveillance posts in TumintingSubdistrict, Manado, Indonesia.Results Among 359 under-five children, 296 were well-nourishedand 63 had mild to moderate malnutrition. The ability to sit withoutsupport in malnourished children was significantly delayed com-pared to that in well-nourished ones (P=0.03). The ability to walkwithout support and parachute sign were not significantly differentbetween the two groups.Conclusion The ability to sit without support in children with mildto moderate malnutrition is delayed compared to that in well-nour-ished ones
Birth weight and blood pressure in first-grade elementary school students: A preliminary study Adrian Umboh; Stefanus Gunawan
Paediatrica Indonesiana Vol 45 No 6 (2005): November 2005
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi45.6.2005.251-5

Abstract

Background Fetal programming theory reveals that low birthweight is associated with higher risks of hypertension and cardio-vascular diseases in the adulthood.Objective To study the difference in blood pressure among first-grade students of different birth weight groups.Methods A cross-sectional study was performed. Blood pressureof 214 healthy first-grade elementary school students (102 malesand 112 females) in Bunaken Subdistrict, Manado, Indonesia, wasmeasured using a standard sphygmomanometer with appropriatecuff for arm size. Two readings were taken. Parents were asked tocomplete a questionnaire concerning the information on birth weightand length and confirmed by retrieving the record on a growthchart and/or a maternal-child health book. The subjects were di-vided into 6 groups according to their birth weight. The differencesin blood pressure values between birth weight groups were exam-ined by ANOVA.Results Systolic blood pressures were significantly higher in the<2500 g birth weight group (100.73+9.99 mmHg vs. 93.70+8.29mmHg) and in the 2500-<3000 g birth weight group compared tothose of the 3500-<4000 g one (99.56+9.14 mmHg vs. 93.70+8.29mmHg) with a P of 0.048 and 0.014, respectively. There was nodifference between diastolic blood pressure and birth weight.Conclusion Our study showed that the lower birth weight grouptends to have a higher systolic blood pressure than that of childrenwith normal birth weight