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All Journal SRIWIJAYA JOURNAL OF MEDICINE Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Stefanus Lembar, Stefanus
Departemen Patologi Klinik, Fakultas Kedokteran Unika Atma Jaya
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Correlation Between Neutrophil to Lymphocyte Ratio (NLR) and Patient with Heart Failure: Haematology Variables in Patient with Heart Failure Rinaldi, Fransiskus Xaverius; Lembar, Stefanus; Ridjab, Denio Adrianus; Leonardo, Leonardo; Lauryn, Jessica; Erlina, Erlina; Singgih, Gregiorio Gavriel
Sriwijaya Journal of Medicine Vol. 5 No. 1 (2022): Vol 5, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v5i1.124

Abstract

Heart failure is a condition of the heart that cannot pump blood adequately resulting in systemic tissue hypoperfusion. This situation will cause systemic inflammatory reactions. Neutrophil to Lymphocyte Ratio (NLR) is an inexpensive and easy parameter that can see inflammatory reactions. This research uses descriptive and analytical studies with cross-sectional studies. The number of samples was 67 heart failure patients who were treated at Atma Jaya Hospital. The statistical test used is unpaired T-test to see if there was a correlation between the NLR value in heart failure, after that NLR cut-off point will be analyzed using a receiver operating curve (ROC). Pearson correlation test was conducted to see the correlation of NLR with laboratory results, including haemoglobin, hematocrit, leukocytes, and platelet. The results showed a significant difference of NLR between controls and heart failure patients (p = 1.0402-10). The cut-off point is 2.16 with an area under the curve of 86.4%, sensitivity 79.1%, and specificity 91%. Analysis of NLR data on heart failure with hemoglobin (p = 0.108), hematocrit (p = 0.091), and platelets (p = 0.832) showed no significant correlation, whereas showed a significant correlation with leukocytes (p = 0.017). This study shows a significant difference of NLR between control and heart failure therefore it can be used to predict the prognosis for heart failure. This study also found no significant correlation between NLR with the amount of haemoglobin, hematocrit, and platelets, while there was a correlation with leukocytes.
Peranan Rasio Neutrofil terhadap Limfosit, Rasio Monosit terhadap Limfosit, dan Jumlah Relatif Eosinofil pada Pasien Dermatitis Atopik Djuanda, Stephanie; Lembar, Stefanus; Hidajat, Inneke Jane; Djuanda, Dani
Majalah Kedokteran Indonesia Vol 70 No 12 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, V
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.12-2020-305

Abstract

Introduction: Atopic Dermatitis (AD) is an inflammatory skin disorder characterized by chronically relapsing inflammation accompanied by pruritus and itching. Inflammatory mechanism and many body immune responses are involved in AD. There are several diagnostic tests to diagnose AD. NLR, MLR and relative eosinophil count are parameters that can be obtained easily and cheap from the economic side. The purpose of this study is to determine the role of neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR) and relative eosinophil count in AD patients with analyzing the sensitivity and specificity.Methods: This research is done by a cross-sectional method with peripheral blood smear. The number of sample taken were 61 patients with AD who had fulfilled the inclusion and exclusion criteria and 61 healthy controls. The data is then analyzed using Komolgorov-Smirnov and Saphiro-Wilk normality test, Independent T test, Mann-Whitney U.Result: The data analysis result shows a not statistically significant relationship between NLR in AD patients and healthy controls, p=0,858. This study also shows a significant relationship between MLR and relative eosinophil count in AD patients and healthy controls with p=0,000 and p=0,013. The cut-off point of MLR and relative eosinophil count each are less than 0,0488 (sensitivity 70,5%, specificity 72,1%, AUC 72,5%) and greater than 2,25 (sensitivity 70,5%, specificity 77%, AUC 78%).Conclusion: MLR and relative eosinophil count can be proposed as diagnostic tools in assisting the diagnosis of AD, however NLR can not be used as AD diagnostic tool
Co-Authors Djuanda, Dani Djuanda, Stephanie Erlina Erlina Hidajat, Inneke Jane Lauryn, Jessica Leonardo Leonardo Ridjab, Denio Adrianus Rinaldi, Fransiskus Xaverius Singgih, Gregiorio Gavriel