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All Journal INKUIRI : Jurnal Pendidikan IPA Prosiding Seminar Nasional Darmajaya Sumatera Medical Journal
Indah Damayanti, Indah
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Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Other

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Journal : Sumatera Medical Journal

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Correlation of Depression Symptoms and Interleukin-6 in Chronic Renal Disease with Regular Hemodialysis Patients Damayanti, Indah; Nasution, Habibah Hanum; Lubis, Wika Hanida
Sumatera Medical Journal Vol. 1 No. 1 (2018): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (5235.571 KB) | DOI: 10.32734/sumej.v1i1.442

Abstract

Depression is psychosomatic disorder are common in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). Correlated with morbidity and mortality associated with chronic inflammation in patients, that characterized by elevated levels of plasma cytokines, especially interleukin (IL)-6. Objective: To investigate the correlation of depressive symptoms with IL-6 levels in patients with CKD who underwent regular HD. Methods: One hundred and 29 CKD patients were enrolled in this cross- sectional study. All eligible patients were screened for IL-6 level. Beck Depression Inventory (BDI) II questioner were then given to determine the presence of depression. Level of IL-6 was then correlated with BDI score using Spearman test. Result: The mean BDI score was 19,32 ± 6,18 indicating the level of mild depression symptoms, and the mean IL-6 level (8,697 ± 6,947 pg/mL) was still within normal range. There was a moderate positive correlation (r = 0.417) between the level of depressive symptoms and IL- 6 levels. Conclusion: There was a moderate positive correlation (r = 0.417) between IL-6 levels and depressive symptoms in patient with HD. However, mean IL-6 levels in depressive patients are still within normal limits indicating that the cause of depression is multifactorial.
Co-Authors Bulan Tati Fitria Habibah Hanum Nasution, Habibah Hanum Lubis, Wika Hanida Mohammad Masykuri Pratama, Rian Andesta Sri Yamtinah