Teguh Marfen Djajakusumah, Teguh Marfen
Department of Surgery, Faculty of Medicine, Universitas Padjadjran, Dr.Hasan Sadikin General Hospital, Bandung

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Anti-inflammatory Effect of Trigona spp. Propolis in Restricting Edema Volume Nurhayati, Wulantika; Dewi, Vycke Yunivita Kusumah; Djajakusumah, Teguh Marfen
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

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Abstract

  Background: Inflammation is a normal response that potentially harmful if it is uncontrolled. On the other hand, it is necessary to find an alternative anti-inflammatory as most anti-inflammatory drugs available nowadays still have adverse effects. Trigona spp. propolis is one of the potential anti-inflammatory alternatives because of its flavonoid, especially caffeic acid phenethyl ester, which is known as an active compound in anti-inflammatory process. This study aimed to understand the anti-inflammatory effect of Trigona spp. prolisin reducing edema volume in rat’s paw.Methods: An experimental study was performed on 20 male wistar rats. The rats were divided into control and experimental groups with 10 rats in each group. Control group was treated by propylene glycol 1 ml/day and experimental group was treated by Trigona spp. propolis 200 mg/kg body weight/day. The inflammation was induced by subcutaneous injection of λ-carrageenan 1% at plantar one hour after the treatment. Edema volumes were measured by plethysmometer every hour at 1 to 6 hours and once at 24 hours after induction. The difference in edema volumes was calculated in percentage. This study was conducted during October 2012 at the Pharmacology and Therapy Laboratory, Faculty of Medicine, Universitas Padjadjaran Bandung.Results: The increase of edema volume (in percentage) in control group and Trigona spp. propolis treated group are 100.64±32.22 and 56.46±20.38 respectively (p value=0.000). Multiple comparisons using Dunnet and Duncan post hoc test showed significant differences that were observed at 3, 4, 5, and 6 hours after inflammatory induction.Conclusion: Trigona spp. propolis has an anti-inflammatory effect in reducing edema volume in rat’s paw. The most significant effect was observed at 3, 4, 5, and 6 hours after inflammatory induction. Trigona spp. propolis might have a potential to be developed as a future anti-inflammatory drug.Keywords: Edema volume, inflammation, propylene glycol, Trigona spp, propolisDOI: 10.15850/amj.v2n1.440 
Frequency of Chronic Venous Disease among Nurses Martanegara, Cendy; Ekowati, RA Retno; Djajakusumah, Teguh Marfen
Althea Medical Journal Vol 2, No 1 (2015)
Publisher : Althea Medical Journal

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 Background: Chronic vein diseases are quite common and its prevalence is also quite high in community. One of the risk factors is occupation with prolonged standing. Quality of life and work efficacy may become risk factors. This disease has not received any special consideration and response. Methods: This is a cross-sectional study performed on nurses working in Dr. Hasan Sadikin General Hospital Bandung (n=98; women=76, men=22). The study was conducted in November 2012 through collecting data on prevalence, risk factors, and clinical symptoms by using questionnaire. Chronic venous disease was observed by direct inspection in lower extremities. Diagnosis was concluded according to the Clinical Etiology Anatomy Pathophysiological criteria. Results: There was a high frequency, i.e. 86.7% (n=71), of chronic venous disease among nurses, with the age group of 20–29 years old (34.1%) as the age group that was mostly affected. Among female nurses, almost all of them experienced the disease (93.4%; n=71). Clinical symptoms felt by most nurses were heavy feeling on legs (82.3%) and cramps (55.3%).Conclusion: The frequency of chronic venous disease among nurses is high, 86.7% and almost all of the female nurses suffer from the disease. The high frequency in females could be caused by risk factors such as parity and hormonal contraception. Those who are mostly affected by the disease are  within range of age 20–29 years old of age. Heavy legs and cramps are the most frequent clinical symptoms felt. Keywords: Chronic vein disease, frequency, nursesDOI: 10.15850/amj.v2n1.432   
Peripheral Arterial Disease among Diabetic Patients in Dr. Hasan Sadikin General Hospital Bandung 2012 Azkiyah, Feriska Fairuz; Djajakusumah, Teguh Marfen; Ekowati, RA. Retno
Althea Medical Journal Vol 2, No 2 (2015)
Publisher : Althea Medical Journal

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Background: As one of the most devastating complication in diabetes mellitus, peripheral arterial disease is still under detected in health care services. This study aimed to reveal the frequency of peripheral arterial disease in diabetic patients in Endocrine and Metabolism Clinic in Dr. Hasan Sadikin General Hospital Bandung.Methods: A cross sectional descriptive study was conducted during the period of October to November 2012 in Endocrine and Metabolism Clinic in Dr. Hasan Sadikin General Hospital Bandung. As many as 54 patients who met the inclusion criteria and agreed to participate in this study signed the informed consent form then underwent history taking, simple physical examination of lower extremities, and Ankle-Brachial Index (ABI) measurement. Normality of the data distribution was calculated by Kolmogorov-Smirnov test.Results: From a total 54 diabetic patients enrolled, it was found 18 cases of peripheral arterial disease, consisted of 10 patients with Ankle-Brachial Index measurement ≤0.9 and 8 patients with Ankle-Brachial Index measurement >1.4. Most of the cases occurred in the elderly group (>60 years old) and had been diagnosed diabetes less than 10 years.Conclusions: The frequency of peripheral arterial disease in diabetic patients attended Dr. Hasan Sadikin General Hospital Bandung is 33.3% and more prevalent in elderly patients. It occurred mostly in patients diagnosed with diabetes less than 10 years. [AMJ.2015;2(1):287–90]
Public Opinion Regarding Information on Porcine-Contained Medications Wibowo, Anindhita Paramita; Syukriani, Yoni Fuadah; Djajakusumah, Teguh Marfen
Althea Medical Journal Vol 4, No 3 (2017)
Publisher : Althea Medical Journal

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Background: Drugs are biological products, a single or combination of active and additives components. Some additional components are derived from porcine, a substance that is haraam for Muslims. Patient’s rights, such as medication information, are substantial in decision-making process. Medical decision-making in the Eastern culture is not only the patient’s affair, but also family’s interest. This study aimed to determine the public opinion on that matter. Methods: This study was conducted in October–November 2014 using qualitative methods. Data collection was performed in the District of Jatinangor, Sumedang Regency by using the purposive sampling method. Six respondents were selected. Data were collected through in-depth interview techniques and were analyzed using content analysis technique.Results: There were 3 main responses regarding the respondent’s opinions. First, respondents showed several attitudes toward drugs in general and also several attitudes toward porcine-contained drugs. Respondents showed concern for the medications used and wished either to be informed or not about the prohibited substance in the drugs. The decision-making process of respondents was performed by each individual or family, with the guidance of religious scholars. In a doctor-patient relationship, the doctors should be more active in providing information on the medications and the opportunity for patients to choose drugs. Respondents also had a high dependency to the physicians in making medical decisions.Conclusions: Public opinion on patient’s rights regarding porcine-contained drugs shows the people’s attitude towards drugs in general and porcine-contained drugs in particular, the decision-making process and the relationship between physicians and patients.Â