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All Journal Indonesian Journal of Tropical and Infectious Disease
Cita Prakoeswa, Cita
Dermato-Venereology Department Medical Faculty Universitas Airlangga / Dr Soetomo Hospital Surabaya - Indonesia
Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health

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ETHNIC AND ATOPIC DERMATITIS: WHAT HAVE WE LEARNED IN ASIAN POPULATION? Prakoeswa, Cita
Indonesian Journal of Tropical and Infectious Disease Vol 3, No 2 (2012)
Publisher : Institute of Topical Disease

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Abstract

Atopic Dermatitis (AD) is a chronic inflammatory skin disease, with relapsing remitting course. Management of AD is challenging due to the complexities of this disease. Two hypotheses concerning the mechanism of AD have been proposed. One holds that the primary defect resides in an immunologic disturbance that causes Ig E-mediated sensitization, with epithelial barrier dysfunction regarded as a consequence of the local inflammation. The others propose that an intrinsic defect in the epithelial cells leads to the barrierdysfunction; the immunologic aspects is considered to be an epiphenomenon. Many studies support that AD is a complex trait which has interactions between genes and environmental factors contributing to disease manifestation, but the result of replicate association between genetic markers and AD is inconsistence. An important factor contributing to this inconsistency is related to population diversity. It is possible that certain genetic markers might contribute to increase the risk in certain ethnic population but not in others, either because of the differences in frequencies of the risk alleles and the specific genes interaction. There is limited information about the role of ethnicity in Asian population. The overall purpose of this review is to present an update on ethnicity approach of AD in Asian population. Research on prevalence, risk factor, innate and adaptive immune response genes, skin barrier dysfunction genes and geneenvironmentinteraction such as epigenetic, is discussed. It is generally approved that the ethnicity of study subject is a key factor in interpreting genetic polymorphism studies. Therefore, discussion of some current areas of research about polymorphism are presented, including filaggrin (FLG) gene and CD14 C-159TSNP. Addressing the issues described above may improve our understanding of AD pathogenesis that has implications for the clinical management of AD.
DAPSONE RESISTANCE IN A Mycobacterium leprae ISOLATE WITH TWO POINT MUTATIONS IN folP GENE FROM A LEPROSY PATIENT Ardiaty, Dinar; Wahyuni, Ratna; Prakoeswa, Cita; Abdullah, Rasyidin; Agusni, Indropo; Izumi, Shinzo
Indonesian Journal of Tropical and Infectious Disease Vol 3, No 2 (2012)
Publisher : Institute of Topical Disease

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Abstract

Drug resistance in leprosy is important for Leprosy Control Program, since the WHO-Multidrug regiment (MDT) has been used for global treatment of leprosy for more than two decades already. A Dapsone resistance case in a Multibacillary (MB) leprosy case is reported. The patient was diagnosed and treated in Tajuddin Chalid Hospital Makassar, South Sulawesi. Previously he was treated in a health center at South Sulawesi and was given a treatment for one year, before referred to the hospital. The leprosy skin lesions are still active with erythematous skin lesions and thickened ear lobe. Bacteriological examination was positive for Acid Fast Bacilli, the Bacterial Index was 3+ and the Morphological Index was 1%. The specimens of M.leprae isolation was sent to the Institute of Tropical Disease Surabaya for drug resistance study. Using the Lp1-2 and Lp3-4 nested primers, PCR test was positive for M.leprae.Sequencing result for folP gene showed a double mutation at codon 53 (ACC / Threonin ) which become (AGG / Arginine). Simultaneous mutation at two nucleotides at one codon has never been reported in Indonesia before and this phenomenon is important for leprosy control policy.
Co-Authors Dinar Ardiaty, Dinar INDROPO AGUSNI Rasyidin Abdullah RATNA WAHYUNI SHINZO IZUMI