Lisda Handayani, Lisda
AKBID Sari Mulia

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Pengaruh Pemberian Ekstrak Etanol dan Ekstrak n-Heksan Daun Ketepeng Cina (Cassia Alata. L) terhadap Waktu Kematian Cacing Pita Ayam (Raillietina Sp.) Secara In Vitro Intannia, Difa; Amelia, Rezki; Handayani, Lisda; Santoso, Heri Budi
JURNAL PHARMASCIENCE Vol 2, No 2 (2015): JURNAL PHARMASCIENCE
Publisher : JURNAL PHARMASCIENCE

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Abstract

ABSTRAK            Indonesia diketahui banyak memiliki tumbuhan yang berkhasiat obat, diantaranya adalah daun ketepeng cina (Cassia alata. L) yang mempunyai khasiat sebagai obat cacing, sariawan, sembelit, panu, kurap, kudis dan gatal-gatal. Tujuan Penelitian: untuk mengetahui pengaruh pemberian ekstrak etanol dan n-heksan daun ketepeng cina (Cassia alata. L) terhadap waktu kematian cacing pita ayam secara in vitro. Metode Penelitian: Merupakan penelitian eksperimental dengan memberikan perlakuan terhadap cacing pita ayam yang direndam dalam ekstrak etanol dan ekstrak n-heksan dengan dosis 25 mg/25 mL, 50 mg/25 mL, 75 mg/ 25mL dan 100 mg/25 mL serta sebagai pembanding adalah mebendazole dengan seri dosis yang sama. Setiap perlakuan dilakukan 3 kali replikasi dengan masing-masing replikasi menggunakan 5 ekor cacing. Waktu kematian cacing dicatat dan dilakukan analisis. Hasil Penelitian: Ekstrak n-heksan diketahui lebih cepat mematikan cacing pita ayam dibandingkan dengan ekstrak etanol, namun masih lebih lambat dibandingkan dengan mebendazole. Dosis  100 mg/ 25mL memberikan waktu kematian yang paling cepat pada semua kelompok, dengan waktu kematian sebagai berikut: 1) Ekstrak etanol 202 menit±17.48, 2) Ekstrak n-heksan 138 menit±26,94 dan Mebendazole 95 menit±21,68. Kesimpulan: Ekstrak etanol dan n-heksan mampu mematikan cacing pita ayam (Raillietina sp.) secara in vitro.Kata kunci: Efek anthelmintic, daun Cassia alata. L, ekstrak etanol, ekstrak n-heksan, Raillietina spAbstractKetepeng Cina (Cassia alata. L) is one of Indonesian medical herb which have properties as an anthelmintic, laxative, treat scabies and itchy. Aim of this study is to understand the effect of ethanolic and n-hexane leaf extract of Cassia alata. L toward mortality time of chicken tapeworm (raillietina sp.) in vitro. Four concentrations (25, 50, 75 and 100 mg/ 25 mL) of each extract were studied in activity, which involved the determination time of death of the tapeworm. Both the extracts exhibited best anthelmintic effect at highest concentration of 100 mg/25 ml.  Mebendazole  in  same  concentration  as  that  of  extract  was included  as  standard  reference. Mortality time for each extracts are 1) Ethanolic extracts 202 minute±17.48; 2) n-hexane extract 138 minute±26.94 and Mebendazole 95 minute±21.68  The ethanolic  and  n-hexane leaf  extracts of Cassia alata. L has effect toward mortality time of chicken tapeworm Raillietina sp. in vitro.Key word: Anthelmintic effect, Cassia alata. L, Ethanolic leaf extract, n-Hexane leaf extract, Raillietina sp
POTENSI MODIFIKASI MODEL PIERS UNTUK PREDIKSI LUARAN IBU DENGAN PREEKLAMSIA PADA RUMAH SAKIT TIPE B DI INDONESIA: PENELITIAN RETROSPEKTIF DI RSUD ANSARI SALEH BANJARMASIN, KALIMANTAN SELATAN Sufriyana, Herdiantri; Handayani, Lisda; Yuliana, Fitri; Syafi'i, Taufiq
Jurnal Ilmu Kesehatan dan Kesehatan Vol 1 No 1 (2017): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v1i1.614

Abstract

ABSTRACTBackground: Preeclampsia is the most common cause (32%) of maternal deaths in Indonesia. Model Piers(Pre-eclampsia Integrated Estimate Risk) can predict the outcomes / complications of pre-eclampsia andassociated with a reduction in maternal morbidity. This study aims to assess the potential modification of themodel to predict the outcome Piers mothers with preeclampsia in Type B hospitals in Indonesia. Methods:This research is a prognostic with the analytical method and quantitative approach retrospectively. This studyused the capture technique stratified random sampling to obtain the medical records of 160 people withpreeclampsia and 160 controls in hospitals Banjarmasin Ansari Saleh 2014. Identified availability ofvariables in the model along with the outer piers preeclampsia. Performed univariate, bivariate andmultivariate corresponding availability of variables the model Piers. Result: eight of the 48 variables in themodel Piers consistently found in all samples, while output available were complication preeclampsiaeclampsia and/or HELLP syndrome. The gestational age was significantly influent eclampsia for the subjectin this study (P <0.05), HELLP syndrome (P <0.05), and a combination of both (P <0.01). Predictive value ofa logistic regression model with the variables that the outer form of the syndrome HELLP or in combinationwith eclampsia is 0.811 (AUC ROC; CI 95% from 0.636 to 0.986) and 0.767 (AUC ROC; CI 95% 0.666 to0.868), while the prediction of eclampsia was not significant (P> 0.05). Conclusion: Modifications Piersmodels to predict potential outcomes of women with preeclampsia in RS type B in Indonesia if it is supportedby policies and standards that consider this model and supported a larger number of samples.