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All Journal Phi : Jurnal Pendidikan Fisika dan Terapan Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmiah Teknik Industri Pharmascience Sistem : Jurnal Ilmu-Ilmu Teknik Jurnal Ilmu Fisika PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmiah Wahana Pendidikan Sasambo Journal of Pharmacy Style : Journal of Fashion Design
Hadi Kurniawan, Hadi
Program Studi Teknik Industri Universitas Diponegoro
Religion Agriculture, Biological Sciences & Forestry Arts Astronomy Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

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Subchronic Toxicity Test of Cincalok Oil Towards Wistar Rats Haematology Nugraha, Fajar; Kurniawan, Hadi; Fajriaty, Inarah; Nurbaeti, Siti Nani; Goh, Sri Wahyuni
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.43023

Abstract

Cincalok is a fermented shrimp product which has the potential to be used as pharmaceutical preparations. Its LD50 showed non-toxic. However, subchronic toxicity tests have not been performed. Therefore, this study aims to determine its subchronic toxicity assay towards haematology in male and female white rats in the Wistar strain. The animals used were divided into six groups, the control group induced with virgin coconut oil (VCO), the dose group induced with Cincalok oil (100, 400, 1000 mg/kg BW), and two satellite groups (control group VCO and 1000 mg/kg BW). Haematological parameters evaluated include hemoglobin, Red Blood Cell Count (RBC), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), leukocytes, basophils, lymphocytes, eosinophils, platelets, and neutrophils. The average level of haematological profile in this study indicated that hemoglobin, MCH, MCHC, basophils, eosinophils, stem neutrophils, neutrophil segments, lymphocytes, and monocytes platelets in female and male rats were still in the normal range.While, there was a decrease in levels below the normal range in the parameters of RBC, leukocytes, MCV and hematocrit. It was concluded that the consumption of cincalok oil orally had no effect in hemoglobin, RBC, MCV, MCH, MCHC, leukocytes, basophils, lymphocytes, eosinophils, platelets, and neutrophil.
Co-Authors Ade, Putut Afani, Selly Ananda, Ersa Andang Firmansyah Andriayani - Anjani, Ayu Paramitha Dianova, Dahlia Edwin Mirzachaerulsyah Erdatama, Fiqry Fajar Nugraha Fajriaty, Inarah Fauzan Romadlon Fitra, Annis Fortuna, Dhea Goh, Sri Wahyuni Hariyanto IH Indri Kusharyanti Minto Basuki Mira Marlianti, Mira Najini, Robby Olvi, Tea Gilda Dara Mula Ridho Ananda Rizky Kurniawan Saharman Gea siti hanisah Siti Nani Nurbaeti Sutantio, Erian Tanu, Yoga Thoyyiba, Azwa Tamara Zahriah, Zahriah