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All Journal PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat ad-Dawaa : Journal of Pharmaceutical Sciences Abdimas Galuh : Jurnal Pengabdian Kepada Masyarakat
Najini, Robby
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Analisis Perbandingan Metode Autodock 4.2 dan Autodock Vina dalam Memprediksi Interaksi Thiazolidinedione dengan Reseptor PPARG Reynaldi, Muhammad Andre; Faradilla, Aulia; Sari, Rafika; Riza, Hafrizal; Najini, Robby
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 7 No. 1 (2024)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i1.47852

Abstract

Introduction: Molecular docking simulation is an in silico method that plays a role in drug discovery and analyzing drug interactions with receptors. The method using Autodock 4.2 and Autodock Vina is widely used in molecular docking simulations, especially for analyzing interactions that occur between ligands and receptors. Aims: This study was aims to compare the Autodock 4.2 and Autodock Vina methods in simulating the docking of thiazolidinedione against PPARG in terms of bond energy and type of interaction parameters. Methods: The method used in this research was molecular docking simulation using Autodock 4.2 and Autodock Vina. The two methods compared the interaction results and binding affinity scores in the thiazolidinedione group against PPARG. Result: The results of this study show that the interactions using the Autodock 4.2 and Autodock Vina methods have similar amino acids that are bound and the same active site. The binding affinity score also shows that the best are troglitazone, pioglitazone, native ligand and rosiglitazone. Conclusion: Based on the results of this study, it shows that molecular docking simulations using the Autodock 4.2 and Autodock Vina methods thiazolidinedione with PPARG have similar docking score patterns and almost the same types of interactions.
Skrining Penyakit Tidak Menular (PTM): #GERMAS untuk Hidup Sehat Tafwidhah, Yuyun; Maulana, Muhammad Ali; Purwanti, Nera Umilia; Rahmawati, Nadia; Najini, Robby; Mahyarudin, Mahyarudin; Liana, Delima Fajar; Pramana, Yoga; Mita, Mita
Abdimas Galuh Vol 6, No 2 (2024): September 2024
Publisher : Universitas Galuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25157/ag.v6i2.14963

Abstract

Pemeriksaan kesehatan secara berkala merupakan salah satu pilar Gerakan Masyarakat Hidup Sehat (GERMAS) yang berguna untuk mendeteksi keberadaan faktor risiko Penyakit Tidak Menular (PTM). Tujuan dari pengabdian masyarakat ini yaitu melakukan skrining PTM meliputi pengukuran tekanan darah, pemeriksaan gula darah, kolesterol, dan asam urat. Metode pelaksanaan skrining PTM yaitu pendaftaran dan wawancara faktor risiko PTM, pengukuran antropometri, pemeriksaan penunjang serta konseling dan edukasi. Skrining ini dilakukan pada 2 (dua) tempat dengan sasaran usia lebih dari 15 tahun. 155 peserta berhasil dijaring dengan hasil karakteristik sebagian besar adalah perempuan dan berada pada usia remaja akhir serta dewasa akhir. Analisis selanjutnya menunjukkan sebagian besar berada dalam kategori normal dan optimal untuk pemeriksaan tekanan darah dan sebagian besar berada dalam kategori normal untuk pemeriksaan gula darah. Temuan lain gambaran pemeriksaan kolesterol yang menghasilkan lebih dari separuh peserta dalam kategori buruk serta hampir separuhnya memiliki kadar asam urat tidak normal. Skrining PTM berguna mengetahui faktor risiko PTM lebih awal agar dapat diambil tindakan berikutnya sebagai langkah pencegahan. Upaya yang dapat diambil antara lain melakukan pola hidup sehat dan berkonsultasi lebih lanjut kepada tenaga kesehatan.
Peningkatan Kualitas Hidup Pasien Hipertensi dan Diabetes Mellitus Melalui Promosi Kesehatan di UPT Puskesmas Alianyang Kota Pontianak: Improving the Quality of Life of Patients with Hypertension and Diabetes Mellitus through Health Promotion at UPT Puskesmas Alianyang Pontianak City Nugraha, Fajar; IH, Hariyanto; Kurniawan, Hadi; Najini, Robby
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 7 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i7.6906

Abstract

The number of people with chronic diseases in Indonesia, especially hypertension and diabetes mellitus, continues to increase, including in the Pontianak City area, West Kalimantan. Alianyang Community Health Center, Pontianak City, is one of the basic health facilities that implements the Chronic Disease Management Program. The problem experienced by patients with chronic diseases such as hypertension and diabetes mellitus is a decrease in quality of life due to the disease they suffer. One of the causes of a decrease in a person's quality of life is a lack of knowledge and motivation in implementing a healthy lifestyle. Health promotion in the form of education on healthy lifestyles needs to be provided directly to patients and to prolanist cadres of the Alianyang Health Center. The targets of this activity are patients and prolanist cadres of the Alianyang Health Center. The activity aims to provide information to patients and prolanist cadres regarding efforts to improve the quality of life of hypertension and diabetes mellitus patients. The method used is health promotion through educational videos and leaflets. The results showed that there were changes before and after the delivery of health promotion, namely that the average participant experienced an increase in knowledge between the pre-test and post-test, namely 63.33 and 79.17 respectively. Evaluation of activities through questionnaires showed that participants felt the material presented was very interesting and participants gained new knowledge through the educational media provided.
Edukasi SWADAIA: Swamedikasi Dispepsia Berbasis Kasus dan Video pada Masyarakat Desa Sungai Kakap, Kabupaten Kubu Raya: SWADAIA Education: Case and Video Based Dyspepsia Self-Medication in the Sungai Kakap Village Community, Kubu Raya Regency Najini, Robby; IH, Hariyanto; Kurniawan, Hadi; Nugraha, Fajar
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 9 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i9.7537

Abstract

The prevalence of dyspepsia in Sungai Kakap Village is ranked third largest based on data from the Sungai Kakap Community Health Center, Kab. Kubu Raya with an incidence of 1,636 cases in 2023. One of the problems experienced by dyspepsia patients is inappropriate self-medication or self-medication. This Community Service Activity (PKM) is aimed at PKK members and Posyandu cadres because they are part of the community and are also an extension of health workers in helping solve problems experienced by dyspepsia patients. The method used in this PKM is case-based and educational videos. This PKM activity consists of several activities including preparation of activities; orientation and coordination of activities; selecting the target audience for educational media creation activities; providing pre-tests and cases at the beginning of activities; providing educational materials; discussion; post-test; evaluation of activity implementation; and data analysis. The output of this community service is publication in local electronic media in West Kalimantan (Suara Pemred/Tanjungpura Times), publication of scientific articles in the Sinta 4 accredited journal " PengabdianMu ", Copyright of educational videos and videos of implementation of activities on the FK UNTAN YouTube channel. The overall results obtained were an increase in knowledge of 27.19% with an average pre-test score (60.6) and post-test score (77.08). According to the evaluation of activities through questionnaires, participants considered the material presented to be very interesting, and the learning media provided was considered to provide new knowledge.
Co-Authors Fajar Nugraha Faradilla, Aulia Hadi Kurniawan, Hadi Hafrizal Riza, Hafrizal Hariyanto IH Liana, Delima Fajar Mahyarudin, Mahyarudin Maulana, Muhammad Ali Mita Mita, Mita Nera Umilia Purwanti, Nera Umilia Pramana, Yoga Rafika Sari Rahmawati, Nadia Reynaldi, Muhammad Andre Tafwidhah, Yuyun