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All Journal HAYATI Journal of Biosciences Jurnal Penelitian Sains Indonesian Journal of Chemistry Molekul: Jurnal Ilmiah Kimia JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat)

Julinar Julinar

Jurusan Kimia, Universitas Sriwijaya

Author-ID : 520566

Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Earth & Planetary Sciences Environmental Science Mathematics Physics Public Health Social Sciences

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Articles

Î²- Sitosterol and Betulonic Acid from n-Hexane Extract the Stem Bark of Tetracera indica Muharni, Muharni; elfita, elfita; Julunar, Julinar; Yohandini, Heni; oktaviani, muthia
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

The Tetraceraindicahasbeen used traditionally to treat various diseases including skin medications, lower blood pressure, fever, headache, wound andgout medicine. The objective of the research was isolatedand characterizedthe ?-sitosterol (1) and betulonicacid (2) fromn-hexaneextract of the stem bark of Tetraceraindica. The dry powder thestembark (550 g)wasmaceration with n-hexane for 24 hrs.Thisextraction process was repeated three times. The n-hexane extract was separated and purified by chromatographytechnique. The structure of isolatedcompound wasdetermined by spectroscopy data UV, IR, NMR and compared with reported data. Two compounds have been isolated and base on spectroscopy data thecompounds is ?-sitosterol (1) andbetulonic acid (2). Betulonic acid is being reported for the first time from T.indica,meanwhile the?-sitosterolpreviously reported from MeOHextractof leaves of T. indicabut is being reported for the first time from the stembarkof T.indica.

Isolation and Phylogenetic Analysis of Thermophile Community Within Tanjung Sakti Hot Spring, South Sumatera, Indonesia Heni Yohandini; . Julinar; . Muharni
HAYATI Journal of Biosciences Vol. 22 No. 3 (2015): July 2015
Publisher : Bogor Agricultural University, Indonesia

A community of thermophiles within Tanjung Sakti Hot Spring (South Sumatera) have been cultivated and identified based on 16S ribosomal RNA gene sequence. The hot spring has temperature 80C-91C and pH 7-8. We used a simple method for culturing the microbes, by enriching the spring water with nutrient broth media. Phylogenetic analysis showed that the method could recover microbes, which clustered within four distinct taxonomic groups: Anoxybacillus, Geobacillus, Brevibacillus, and Bacillus. These microbes closely related to Anoxybacillus rupiensis, Anoxybacillus flavithermus, Geobacillus pallidus, Brevibacillus thermoruber, Bacillus licheniformis, and Bacillus thermoamylovorans. The 16S ribosomal RNA gene sequence of one isolate only had 96% similarity with Brevibacillus sequence in GenBank.

Studi Kandungan Kimia Ekstrak Kloroform dari Benalu Duku (Scurrula atropurpurea (BI) Dans) Muharni Muharni; Dasril Basir; Julinar Julinar
Jurnal Penelitian Sains No 7 (2000)
Publisher : Faculty of Mathtmatics and Natural Sciences

Isolasi Steroid telah dilakukan dengan mengekstraksi bubuk kering benalu duku (Scurrula atropurpurea (BI) Dans) dengan kloroform. Ektrak pekat kloroform dimurnikan dengan teknik kromatografi lapis tipis (KLT) preparatif dengan fasa diam silika gel 60 GF 254 dan eluen etil asetat dan metanol (19:1) dan pengamatan menunjukkan adanya 3 pita noda dengan Rf = 0,21 dan Rf = 0,34 yang tidak membentuk kristal dan Rf = 58 yang memberikan kristal putih. Analisis spektroskopi dari kristal ini memberikan dua steroid hasil isolasi; steroid paertma memiliki waktu retensi (Rt) = 28,9 menit, berat molekul (BM) = 300, rumus molekul C12H32O, dan nilai kesetaraan ikatan rangkap (DBE) = 6. Steroid kedua memiliki Rt = 29,5 menit, BM = 412, rumus molekul C29H48O, dan nilai DBE = 6. Kedua jenis steroid tersebut dapat dilaporkan sebagai pregn-14-en-3-on (BM 300) dan Stigmasta-5,22-dien-3-oh (BM 412).

Pengaruh Proses Pengukusan Terhadap Daya Awet Rendang Daging Sapi yang Dikemas Julinar Julinar; Ester Lidya; Fatma Fatma
Jurnal Penelitian Sains No 18 (2005)
Publisher : Faculty of Mathtmatics and Natural Sciences

Penjelasan tentang pengaruh proses pengukusan terhadap daya awet rendang daging sapi yang dikemas telah dilakukan. Produk rendang dikemas dalam plastik tahan panas dan pengukusan dilakukan selama 60 menit. Penelitian dilakukan dengan menggunakan Rancangan Acak Lengkap (RAL), dengan 8 taraf lama penyimpanan yaitu 0, 1, 2, 3, 7, 14, 21, 28 dan 35 hari. Analisis nilai gizi produk rendang meliputi kadar air, kadar lemak dan kadar protein. Uji organoleptik juga dilakukan untuk mengetahui tingkat kesukaan panelis terhadap produk rendang yang dikukus dan disimpan. Dari analisis keragaman terhadap kadar air, lemak dan protei, menunjukkan bahea perlakuan pengukusan memberikan pengaruh nyata (P<0,05), tapi berdasarkan uni beda nyata jujur (BNJ) antara setiap perlakuan sebagian besar menunjukkan perbedaan yang tidak nyata, ini menunjukkan bahwa proses pengukusan cukup baik untuk mempertahankan mutu rendang daging sapi.

Flavon Compound from The Ethyl Acetate Extract of The Stem of Supit (Tetracera indica Merr.) Muharni Muharni; Elfita Elfita; Riska Adillah; Heni Yohandini; Julinar Julinar
Molekul Vol 13, No 1 (2018)
Publisher : Universitas Jenderal Soedirman

Tetracera indica Merr. in Musi Banyuasin, is one of the traditional medicine used by the community for the treatment of kidney stone disease and gout, but this claim is not recorded in the treatment of kidney stones and gout in Indonesia. In this study, isolation of antioxidant compound from ethyl acetate extracts of supit (Tetracera indica) was done. The isolation was carried out through step gradient polarity extraction, and separated and purified by chromatography technique. The determination of the structure of the isolated compound was performed by spectroscopy method including UV, IR, and NMR 1D and 2D, and antoxidant activity was determined by DPPH method. An active antioxidant compound was isolated from ethyl acetate extract in form of yellow solid (15 mg). Based on spectroscopic analysis the isolated compound was 5,8-dihydroxy-7-methoxyflavone. The compound showed strong antioxidant activity (IC50 8.25 μg/mL) higher than standard ascorbic acid (IC50 11.3 μg/mL). This data concluded that efficacy of supit (Tetracera indica) for the treatment related to antioxidant activity (uric acid) is proven by the identification of one antioxidant compound of this plant.

Produksi Tablet Kosmetika Herbal Buah Tembesu Untuk Perawatan Kulit dan Wajah Addy Rachmat; Julinar Julinar; Desnelli Desnelli; Dasril Basir
JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) VOL. 4 NOMOR 2 SEPTEMBER 2020 JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat)
Publisher : Lembaga Publikasi Ilmiah dan Penerbitan (LPIP)

Buah Tembesu (Fragraea fragrans) memiliki metabolit sekunder asam ursolat, asam oleanolat, dan alkaloid gentianin. Senyawa metabolit sekunder ini telah diteliti dan dapat dimanfaatkan sebagai antiinflamasi, antikanker, antibakterial, antiaging, antifungal, antiviral, antialergik. Senyawa flavonoid juga teridentifikasi pada buah ini yang dapat digunakan sebagai antioksidan dan peredam radikal bebas penahan ageing; dan tanin trimer sebagai antikerut (antiwrinkle). Produk kosmetika herbal dari buah Tembesu telah diuji dan memberikan manfaat bagi peningkatan kesehatan kulit dan wajah. Warga di Desa Limbang Jaya II memiliki pemukiman yang kaya akan pohon Tembesu. Kegiatan pengabdian berupa penyuluhan dan pelatihan pembuatan kosmetika alam akan memberikan nilai lebih bagi hasil alam di desa tersebut. Produk kosmetika ini lebih disukai oleh remaja milenial saat ini karena tidak saja halal tetapi juga berkhasiat untuk perawatan tanpa ada efek samping karena hanya mengandung bahan alami.

Oxidation and Acetylation of Ursolic and Oleanolic Acids Isolated from Fragraea fragrans fruits; Antiproliferation of P388 Leukemia Cells Dasril Basir; Julinar Julinar; Eva Agustriana; Budi Untari
Indonesian Journal of Chemistry Vol 14, No 3 (2014)
Publisher : Universitas Gadjah Mada

An interesting natural product chemistry aspect of Fragraea fragrans is that their fruits are richness with ursolic acid and its isomer oleanolic acid (3.05% of dried powder). As our continuous work on these inseparable structural isomeric triterpenes, this paper reports that 51.0% of inseparable 3-oxo-ursolic[3-oxo-oleanolic] acids and 48.6% of inseparable 3-acethyl-ursolic [3-acethyl-oleanolic] acids have already been made from those triterpenes as starting materials of the oxidized and acetylated compounds and evaluated their activity against P388 leukemia cells. The activity of 3-oxo-ursolic [3-oxo-oleanolic] acids with IC50 = 18.6 µg/mL exhibited three-fold more potent against P388 leukemia cell proliferations compared to ursolic [oleanolic] acids with IC50 = 53.5 µg/mL; while the 3-acethyl-ursolic [3-acethyl-oleanolic] acids with IC50 = 37.9 µg/mL showed two-fold more potent then their parent triterpenes (IC50 = 53.5 µg/mL) in the inhibition of P388 leukemia cell growth.

THE RESTORATIVE COSMETIC CONSTITUENTS OF Fragraea fragrans FRUITS Dasril Basir; Julinar Julinar
Indonesian Journal of Chemistry Vol 12, No 1 (2012)
Publisher : Universitas Gadjah Mada

This paper describes 3-hydroxyurs-12-en-28-oic acid and its structural isomer 3-hydroxyolean-12-en-28-oic acid isolated from Fragraea fragrans fruits and their biological activities; anti-tumor, anti-inflammation, anti-microbial, and anti-fungal included their ultra violet photo-protective effect after exposed under sunlight radiation. They are useful for cosmetic ingredient. The above triterpenes are very promoting compounds for leukemia L1210 anti-tumor due to limited reports dealing with this type triterpenoid anti-tumor test. They significantly gave IC50 value of 5.78 µg/mL against leukemia L1210 cells, relatively closed to IC50 value of drugs, 4.0 µg/mL [12-13,17].

Co-Authors Addy Rachmat Budi Untari Dasril Basir Desnelli Desnelli Elfita Elfita Elfita Elfita Ester Lidya Eva Agustriana Fatma Heni Yohandini Muharni Muharni Muharni Muharni oktaviani, muthia Riska Adillah

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