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All Journal Pharmaceutical Sciences and Research (PSR) Makara Journal of Science
Rudiyansyah,
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Cytotoxic Activity of Stem of Pycnarrhena cauliflora through Apoptosis Induction on Human Breast Cancer Cell Line T47D Masriani,; Rudiyansyah,; Muharini, Rini; Enawaty, Eny
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Cytotoxic activities of extracts of Pycnarrhena cauliflora leaves, stems and roots on some human cancer cells have been known. However, the cytotoxicity of stem of Pycnarrhena cauliflora on human breast cancer cell line T47D through an apoptosis induction has not been proven yet. This study was an effort in understanding the cytotoxic activity of stem of Pycnarrhena cauliflora through apoptosis induction. The crude ethanol extract was partitioned between n-hexane and dichloromethane at pH 3, 7 and 9, which was subsequently tested for their cytotoxic activity against human breast cancer cell line T47D by using 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide (MTT). Flow cytometric analysis with Annexin V-FLUOS/ propidium iodide (PI) double staining was used for apoptosis analysis. The dichloromethane fraction at pH 7 was considered the most potent with an IC50 value of 59.30 µg/mL and induced apoptosis on the T47D cell line. The result indicated the potential of dichloromethane fraction of the stem of P.cauliflora as a source of bioactiv
The Use of TiO2-SiO2 in Photocatalytic Process to Degrade Toxic and Dangerous Waste Destiarti, Lia; Tjokronegoro, Roekmiati; Rakhmawaty, Diana; Rudiyansyah,
Makara Journal of Science
Publisher : UI Scholars Hub

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This study was conducted to investigate the use of TiO2 immobilized on SiO2 (TiO2-SiO2) in a photocatalytic process to degrade toxic industrial waste, phenol, linear alkylbenzene sulfonate (LAS), and Cr(VI), which is dangerous for humans and the environment. Titanium dioxide (TiO2), as a photocatalyst, can make the solution become turbid. Thus, TiO2-SiO2 was used to increase the possibility of ultraviolet (UV) transmission. The phenol and LAS levels were measured with the Indonesian National Standard (INS) while the Cr(VI) level was determined with the colorimetric method. The activity test for the catalyst in suspension and immobilization against phenol showed that TiO2-SiO2 was more active than TiO2. By using the photocatalytic process with the TiO2-SiO2 photocatalyst for 8 h, degradation of phenol and LAS reached 50% as a single compound and 12% as a mixture. However, TiO2-SiO2 did not decrease Cr(VI)
Co-Authors Destiarti, Lia Diana Rakhmawaty Eny Enawaty Masriani . Rini Muharini Roekmiati Tjokronegoro, Roekmiati