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Wibisono Nugraha
Bagian Ilmu Kesehatan Kulit dan Kelamin, Fakultas Kedokteran, Universitas Sebelas Maret Surakarta/RSUD Dr. Moewardi, Surakarta
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Korelasi Kadar Serum Nitrit Oxide (NO) dengan Tipe dan Derajat Keparahan Psoriasis Fiska Rosita; Bobby Febrianto; Ambar Aliwardani; Putti Fatiharani; Wibisono Nugraha; Muhammad Eko Irawanto; Nurrachmat Mulianto
MEDICINUS Vol 34 No 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (103.767 KB) | DOI: 10.56951/medicinus.v34i2.61

Abstract

Psoriasis is a chronic, immune-mediated disorder that results from a polygenic predisposition. Nitric oxide (NO) has been considered as important factors in the pathogenesis of psoriasis. This study aims to determine the correlation of serum NO levels with the type and severity of psoriasis. This cross-sectional study was conducted from May to September 2018. Difference in the average of serum NO levels in psoriasis patients with control groups is analyzed using t-test. The Spearman correlation test was used to see the correlation of serum NO levels with type and severity of psoriasis measured by Psoriasis Area and Severity Index (PASI) score. There was significant difference between serum NO level in the control group compared to the group of psoriasis patients (p=0.037). Patient with generalized pustular psoriasis has the highest mean of NO level (59.07 µmol/L). There was no significant correlation between serum NO level with type (r=0.008, p=0.9710 and severity (r=0.157, p=0.486) of psoriasis. Nitric oxide levels are elevated in psoriasis patients, which indicate that oxidative stress plays an important role in the etiopathogenesis of psoriasis.
Profil Pemphigus Vulgaris di Instalasi Rawat Inap RSUD Dr. Moewardi Surakarta Periode Januari 2014-Desember 2019 Eka Devinta Novi Diana; Wibisono Nugraha; Alfina Rahma; Frieda; Anindya Oktafiani; Rieska Widyaswari; Muhammad Eko Irawanto
MEDICINUS Vol 34 No 3 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (111.003 KB) | DOI: 10.56951/medicinus.v34i3.79

Abstract

Background: Pemphigus vulgaris is life-threatening autoimmune bullous disease caused by acantholysis of keratinocytes and disruption of adhesion function of desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3). The clinical manifestation of pemphigus vulgaris is flaccid bullae that affect all parts of the body with mucosal involvement. This study aimed to evaluate profile of pemphigus vulgaris cases among hospitalized patients in Dr.Moewardi General Hospital Surakarta Januari 2014-December 2019. Methods: This descriptive retrospective study was conducted using medical record data of pemphigus vulgaris patients hospitalized at Dr.Moewardi General Hospital Surakarta between January 2014 and December 2019. Results: Total pemphigus vulgaris cases in 6 years is 25 cases, with most affected age range was 51-60 years (36%), and dominated by female (80%). Mucocutaneous involvement was found in 60% cases and the most common comorbidity disease in this study was hyperglicemia (20%) and the most common laboratory abnormality was hipoalbuminemia (32%). Systemic corticosteroid was given to 52% patients and the rest (48%) was given combination therapy with immunosuppressant such as mycophenolate mofetil (20%), cyclosporine (16%), and azathioprine (12%). Conclusion: Pemphigus vulgaris mostly affected female between age 51-60 years. Monotherapy with systemic corticosteroid was effective in most patients (52%).
Tinjauan Histopatologi pada Pyoderma Gangrenosum dengan Infeksi Sekunder Wibisono Nugraha; Danu Yuliarto; Eka Devinta Novi Diana; Alfina Rahma; Prasetyadi Mawardi; Frieda; Ambar Mudigdo
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.123

Abstract

Background: Pyoderma gangrenosum (PG) is a complex neutrophilic dermatosis, characterized by sterile, painful, necrotic ulcer, and is associated with systemic conditions. PG manifests as papules and vesicles that evolve into painful ulcers. Incidence of PG is relatively rare in Dr. Moewardi Hospital, so it is important to identify and correctly diagnose PG based on its’ histopathological features. Case A 54-year-old man complained of painful scab on several body parts. Hematoxylin and eosin staining in the epidermal layer showed a basket-weave orthokeratosis with necrotic tissue, acanthosis, and basal cell hypermelanosis. In the dermis layer there is a lymphocyte and neutrophil cell infiltrate with slight appearance of leukocytoclastic. Discussion: Pyoderma gangrenosum is a reactive, non-infectious inflammatory dermatosis (neutrophilic dermatoses). In this case, PG occurs in 54-year-old man as painful scab on back and legs. Classical PG characterized by papules, pustules, crusted or necrotic plaque, which typically have undermined, overhanging, dusky purple edges with surrounding induration and erythema. In this patient, the epidermal layer showed ulceration and slight appearance of leukocytoclastic vasculitis in the dermis area and lymphocyte infiltrate with slight neutrophil in the perivascular accompanied by erythrocyte extravasation, which support the diagnosis of PG.
Co-Authors Alfina Rahma Ambar Aliwardani Ambar Mudigdo Anindya Oktafiani Bobby Febrianto Danu Yuliarto Eka Devinta Novi Diana Fiska Rosita Frieda Muhammad Eko Irawanto Nurrachmat Mulianto Prasetyadi Mawardi Putti Fatiharani Rieska Widyaswari