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Ambar Aliwardani
Bagian Ilmu Kesehatan Kulit dan Kelamin, Fakultas Kedokteran, Universitas Sebelas Maret Surakarta/RSUD Dr. Moewardi, Surakarta
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Korelasi Kadar Serum Nitrit Oxide (NO) dengan Tipe dan Derajat Keparahan Psoriasis Fiska Rosita; Bobby Febrianto; Ambar Aliwardani; Putti Fatiharani; Wibisono Nugraha; Muhammad Eko Irawanto; Nurrachmat Mulianto
MEDICINUS Vol 34 No 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (103.767 KB) | DOI: 10.56951/medicinus.v34i2.61

Abstract

Psoriasis is a chronic, immune-mediated disorder that results from a polygenic predisposition. Nitric oxide (NO) has been considered as important factors in the pathogenesis of psoriasis. This study aims to determine the correlation of serum NO levels with the type and severity of psoriasis. This cross-sectional study was conducted from May to September 2018. Difference in the average of serum NO levels in psoriasis patients with control groups is analyzed using t-test. The Spearman correlation test was used to see the correlation of serum NO levels with type and severity of psoriasis measured by Psoriasis Area and Severity Index (PASI) score. There was significant difference between serum NO level in the control group compared to the group of psoriasis patients (p=0.037). Patient with generalized pustular psoriasis has the highest mean of NO level (59.07 µmol/L). There was no significant correlation between serum NO level with type (r=0.008, p=0.9710 and severity (r=0.157, p=0.486) of psoriasis. Nitric oxide levels are elevated in psoriasis patients, which indicate that oxidative stress plays an important role in the etiopathogenesis of psoriasis.
Terapi Oral dan Tetes Mata Topikal pada Green Nail Syndrome Putti Fatiharani Dewi; Ambar Aliwardani; Nugrohoaji Dharmawan
MEDICINUS Vol 34 No 3 (2021): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (140.156 KB) | DOI: 10.56951/medicinus.v34i3.81

Abstract

Background: Green nail syndrome is one of the chromonychia caused by infection of Pseudomonas aeruginosa, characterized by onycholysis and greenish-black discoloration of the nail. There were no reports regarding the incidence of green nail syndrome in Indonesia. Predisposing factors for the occurrence of green nail syndrome include onychomycosis, high activity in moist and wet conditions, diabetes mellitus, and immunosuppression. Case: A 51-year-old man complained about greenish-black discoloration on his fingernails. Dermatological examination in 1st and 3rd digit of the right hand, as well as 1st digit of the left hand, found multiple greenish-black discoloration with onychodystrophy. Dermoscopy examination of the affected nails showed greenish-black pigmentation in the distolateral nails with peripheral fading. Culture examination using MacConkey agar showed colonies of greenish-brown pigments. The patient was diagnosed with green nail syndrome and treated with ciprofloxacin 500 mg/day and topical polymixin B eye drops b.i.d. for 3 weeks, resulting in good outcome. Discussion: The diagnosis of green nail syndrome is made based on anamnesis, physical examination, and bacterial culture. showing a distinctive feature. The predisposition factor in this case, is the frequent washing hands habit of the patient up to more than ten times per day. Treatment using topical eye drops facilitates the absorption of active ingredients into the nails.
Modalitas Terapi Striae Ambar Aliwardani; Putti Fatiharani Dewi; Fiska Rosita; Indah Julianto
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.124

Abstract

Striae or strechmark is a form of benign skin lesion manifested as inflammatory streaks perpendicular to the direction of skin tension which has cosmetic morbidity and possesses risk of secondary infection in severe case. Various therapeutic modalities have been introduced, such as topical therapy, physical therapy using devices, lasers, and the latest is celullar therapy using platelet-rich plasma. Such varied treatment modalities are reported to have varied results.
Co-Authors Bobby Febrianto Dharmawan, Nugrohoaji Fiska Rosita Fiska Rosita Indah Julianto Muhammad Eko Irawanto Nurrachmat Mulianto Putti Fatiharani Putti Fatiharani Dewi Wibisono Nugraha