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NITA PRANITASARI
Fakultas Kedokteran Universitas Hang Tuah Surabaya
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Pengaruh Pemberian Ekstrak Jambu Biji (Psidium guajava) Terhadap Kadar Trigliserida Darah Tikus Putih (Rattus norvegicus) Jantan Galur Wistar Yang Diinduksi Deksametason MARIA EVANE NAVY CAHAYA PUTRI; NITA PRANITASARI
HANG TUAH MEDICAL JOURNAL Vol 16 No 1 (2018): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background Dexamethasone induction may result in increased of both triglyceride synthesis and VLDL plasma level, which contribute to the increase in triglyceride level. Guava (Psidium guajava) consists flavonoid (quercetin) compounds that can inhibit triglyceride synthesis and decrease blood triglyceride level. Method This research used 24 rats divided into 3 groups: group of rats fed with standard food, group of rats induced by 0.13 mg/kgBW dexamethasone for 14 days starting from day 8, and group of rats induced by 0.13 mg/kgBW dexamethasone for 14 days starting from day 8 and received 3 gr/kgBW guava extract for 21 days. On day 22, blood triglyceride level was measured with glycerol blanking method. Result The result of Mann-Whitney U test showed that blood triglyceride level of group of rats induced by dexamethasone ( X =198.25±55.296 mg/dl) was significantly higher (p=0.001) than group of rats fed with standard food ( X =68.50±16.062 mg/dl). Blood triglyceride level of group of rats induced by dexamethasone and received guava extract ( X =98.75±26.778 mg/dl) did not significantly decreased (p=0.487) compared to group of rats induced by dexamethasone ( X =198.25±55.296 mg/dl). Conclusion The conclusion of this research showed that dexamethasone significantly increased blood triglyceride level and guava extract tend to decrease blood triglyceride level because guava consists flavonoid (quercetin) compounds.
Pengaruh Ekstrak Daun Sirsak Terhadap Gambaran Histopatologi Pankreas Rattus Norvegicus Jantan yang Diinduksi Aloksan RIFKY YOGA PRATAMA; NITA PRANITASARI; DIAH PURWANINGSARI
HANG TUAH MEDICAL JOURNAL Vol 17 No 2 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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ABSTRACT Background: Diabetes melitus is a metabolic disorder characterized by an increase in blood glucose levels caused by disruption of the pancreas in producing insulin. Alloxan is a substrate that can trigger the condition of hyperglycemia which can cause diabetes because of its toxic nature to pancreatic beta cells. The aim of this study to find out about the effect of soursop leaf (Annona muricata Linn) extract in repaired to pancreatic tissue damage of male wistar rats (Rattus norvegicus) induced by alloxan. Method : 24 male Wistar rats, divided into 3 groups : K(-) group that no treatment, K(+) group that induced by alloxan dose 150mg/kgBW and K(p) group that induced by alloxan dose 150mg/kgBW and given soursop leaf extract dose 150mg/kgBW. Result : there was significant difference (p = 0.001) of pancreatic tissue damage measured by histopathologic score between group of no treatment rats compared to the group of rats induced by alloxan. There was a significant difference of pancreatic tissue damage measured by histopatology score group of rats induced by alloxan compared to group of rats induced by alloxan and given soursop leaf extract. Conclusion : the administration of alloxan significantly increases the pancreatic tissue damage and the administration of soursop leaf extract can improve pancreatic tissue damage measured by histopathology score because soursop leaf extract contains flavonoids and tannins which function as antioxidants.
Pengaruh Alginat dari Alga Coklat (Sargassum sp) terhadap Penyembuhan Luka Diabetes Melitus pada Tikus yang Diinduksi Streptozotocin TAUFAN ANTARISKA; NITA PRANITASARI; JUDYA SUKMANA; IRMA ANDRIANI PASARIBU
HANG TUAH MEDICAL JOURNAL Vol 19 No 2 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v19i2.212

Abstract

Diabetes mellitus is a degenerative disease which its prevalence increases over time, this disease is often overlooked, thereby increasing complications. Uncontrolled long-term hyperglycemia will cause sensory nerve and blood vessel function disorders. Disruption of the non-healing chronic wound reparation process due to this condition will result in excessive ROS level accompanied by secondary infection, increasing the risk of amputation and death. On the other hand, alginate produced by the cell walls of brown algae (Sargassum sp) is believed to be able to increase the formation of new blood vessels, balance excessive ROS level, and prevent infection at the wound site. This study was conducted to examine the effect of topical alginate on wound healing in diabetic rats. The population in this study includes articles that discuss wounds healing process in diabetic rats induced by streptozotocin (STZ) given alginate therapy. The research sample was obtained from data that had been affixed in 15 international research articles indexed by Scimago from 2016 to 2021. The method used in this study was a literature review. This research took place from May to December 2021.The results of the 15 articles reviewed revealed that alginate could improve wound healing in STZ-induced diabetic rats, this was indicated by decrease in duration of wound closure and inflammation, increase proliferation of epithelial cells and collagen density, and prevent the occurrence of secondary infection at the wound site. Based on these findings, it was concluded that topical administration of alginate had a good effect on the wound healing process of STZ-induced diabetic rats. Keywords: Alginate; diabetic mice; streptozotocin; wound healing
Co-Authors DIAH PURWANINGSARI IRMA ANDRIANI PASARIBU Judya Sukmana MARIA EVANE NAVY CAHAYA PUTRI RIFKY YOGA PRATAMA TAUFAN ANTARISKA