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DIAH PURWANINGSARI
Fakultas Kedokteran Universitas Hang Tuah Surabaya
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Pengaruh Ekstrak Daun Sirsak Terhadap Gambaran Histopatologi Pankreas Rattus Norvegicus Jantan yang Diinduksi Aloksan RIFKY YOGA PRATAMA; NITA PRANITASARI; DIAH PURWANINGSARI
HANG TUAH MEDICAL JOURNAL Vol 17 No 2 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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ABSTRACT Background: Diabetes melitus is a metabolic disorder characterized by an increase in blood glucose levels caused by disruption of the pancreas in producing insulin. Alloxan is a substrate that can trigger the condition of hyperglycemia which can cause diabetes because of its toxic nature to pancreatic beta cells. The aim of this study to find out about the effect of soursop leaf (Annona muricata Linn) extract in repaired to pancreatic tissue damage of male wistar rats (Rattus norvegicus) induced by alloxan. Method : 24 male Wistar rats, divided into 3 groups : K(-) group that no treatment, K(+) group that induced by alloxan dose 150mg/kgBW and K(p) group that induced by alloxan dose 150mg/kgBW and given soursop leaf extract dose 150mg/kgBW. Result : there was significant difference (p = 0.001) of pancreatic tissue damage measured by histopathologic score between group of no treatment rats compared to the group of rats induced by alloxan. There was a significant difference of pancreatic tissue damage measured by histopatology score group of rats induced by alloxan compared to group of rats induced by alloxan and given soursop leaf extract. Conclusion : the administration of alloxan significantly increases the pancreatic tissue damage and the administration of soursop leaf extract can improve pancreatic tissue damage measured by histopathology score because soursop leaf extract contains flavonoids and tannins which function as antioxidants.
Hubungan Gambaran Foto Toraks dengan Derajat Keparahan Pasien COVID-19 di RSPAL dr. Ramelan MILLENIAWATI PUTRI NOVITANIA; RIKE ANDY WIJAYA; LILIAWANTI; DIAH PURWANINGSARI
HANG TUAH MEDICAL JOURNAL Vol 19 No 2 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v19i2.187

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Background : The COVID-19 pandemic induced a challenge of the importance of diagnostic evaluation. This includes understanding signs and symptoms in diagnosing the probability of infection. The amount of clinical symptoms from the confirmed COVID-19 patient is the same as the other respiratory diseases, which makes it hard to diagnose at the beginning. The gold standard examination of COVID-19 is RT-PCR test and additional examination that usually done is radiology examination. The most used radiology examination is chest X-ray to identify any anomaly in patient's lungs and to evaluate the disease progress. The purpose of this research is to understand the existence of correlation between chest X-ray imaging and severity degree of COVID-19 patients that are treated in RSPAL dr. Ramelan Surabaya from November 2020-January 2021. Methods : The type of research is analytical observational study with case control design using 44 samples obtained from medical history of inpatients and outpatients that are confirmed positive of COVID-19 treated in RSPAL dr. Ramelan Surabaya in span of November 2020-January 2021. Bivariate analysis was performed using Spearman's test Results : From the result of bivariate analysis using Spearman's test appears significance score (p) = 0.0001 which <0.05 that shows the significant existence of connection between chest X-ray image and severity degree of COVID-19 patients. It is also found that the coefficient correlation score (r ) = 0.985 shows a positive correlation with strong correlation power. Conclusion : There is a connection between chest X-ray images and severity degree of COVID-19 patients. The more severe the clinical symptoms of a patient, the worse that patient's chest X-ray result will be. Keywords : COVID-19, Chest x-ray imaging, Severity degree.
Hubungan Status Gizi Pasien Penyakit Hirschsprung dengan Infeksi Luka Operasi di RSPAL dr. Ramelan Surabaya Periode Waktu 2016-2020 PUTU SITHA AISHWARYA SARASWATI GIUR Giur; SAPTA PRIHARTONO RACHMAN; DIAH PURWANINGSARI; PRAWESTY DIAH UTAMI
HANG TUAH MEDICAL JOURNAL Vol 20 No 1 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v20i1.279

Abstract

Background: Hirschsprung's disease is a congenital intestinal motility disorder that causes functional intestinal obstruction due to the absence of enteric ganglion cells in the distal intestine. The management of each case of Hirschsprung's disease is surgery, where surgery on the digestive tract increases the occurrence of surgical site infections. Disturbances in the gut cause decreased resistance to infection, delayed cognitive development, and problems with nutritional status. Methods: This study was a descriptive and analytical observational study, where the primary data were taken from the registration data of Hirschprung's disease patients at RSPAL dr. Ramelan Surabaya in 2016-2020. The nutritional status of the patient was determined by plotting the weight per age curve according to WHO for children aged 0-5 years. Results: Observations of 38 patients who met the study requirements, obtained 4 patients who had poor nutritional status and 1 patient who had excess nutritional status, none of which experienced complications in the form of surgical wound infections. In 10 patients with poor nutritional status, 2 experienced complications in the form of surgical wound infection and 23 patients with good nutritional status, 1 experienced complications in the form of surgical wound infection. The results of the contingency coefficient correlation test showed P-value = 0.408 (p>α). Conclusion: There was no relationship between the nutritional status of Hirschprung's disease patients with surgical wound infections at RSPAL dr. Ramelan Surabaya Keywords: Hirschsprung's disease, nutritional status of children, surgical site infection.
Co-Authors LILIAWANTI MILLENIAWATI PUTRI NOVITANIA NITA PRANITASARI Prawesty Diah Utami PUTU SITHA AISHWARYA SARASWATI GIUR Giur RIFKY YOGA PRATAMA RIKE ANDY WIJAYA SAPTA PRIHARTONO RACHMAN