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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Hang Tuah Medical Journal
Irmawati Dikman
Fakultas Kedokteran Universitas Hang Tuah Surabaya
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Pengaruh Pemberian Ekstrak Temulawak (Curcuma Xanthorrizha Roxb.) Terhadap Level Nekrosis Pada Jaringan Lien Mencit Putih (Mus Musculus L.) Jantan Galur Balb/c yang Diinokulasi Plasmodium berghei ANKA Muhammad Reyhan Arsya; Prawesty Diah Utami; Irmawati Dikman
HANG TUAH MEDICAL JOURNAL Vol 16 No 2 (2019): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background : Malaria is a disease caused by the Plasmodium, transmitted by Anopheles mosquito and is a health problem in Indonesia. Further development to find new innovations in malaria treatment. Purpose : to determine the effect of temulawak rhizome extract on the level of spleen necrosis of male mice inoculated with Plasmodium berghei ANKA. Methods : a post-test only control group design, used five groups. First group a normal mice, 2nd group was inoculated with Plasmodium berghei ANKA and three treatment groups were inoculated with Plasmodium berghei ANKA and treated with temulawak extract with a dose of 150 mg/KgBB (3rd group), 100 mg/KgBB (4rd group ), and 50 mg/KgBB (5rd group) for four day. On the fifth day observation of the level of spleen necrosis was examination by histopathological Result : the administration of ginger rhizome extract has an influence on the level of necrosis of male mice (Mus musculus L.) BALB / c inoculated with Plasmodium berghei ANKA α = 0,002 (ρ<0,05), where the administration of temulawak extract can increase necrosis levels compared to the control group . This is probably due to the lack of temulawak extract dosage and lack of observation in this study. Conclusion : extract Curcuma xanthorriza Roxb. Has an influence on the level of necrosis of male mice inoculated with Plasmodium berghei ANKA Keywords : Malaria, curcuma (Curcuma xanthorrhiza Roxb.), Necrosis level, Plasmodium berghei ANKA
Pengaruh Pemberian Ekstrak Teripang Pasir terhadap Hambatan Pertumbuhan Shigella Dysentriae Secara In Vitro FERIZAL NEGERI SAMUDRA; RETNO BUDIARTI; Irmawati Dikman
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background; In Indonesia, most diarrhea disease in 1995 to 2001 are caused by Shigella spp. Shigella spp infection can cause various symptom dan complication. Generally, the treatment by using antibiotic can cause antibiotic resistance. Sea cucumber (Holoturia scabra) is an herb that known, available, and easy to consume by society and has an antibacterial effect. Therefore, further research to study the effect of Holoturia Scabra on Shigella Dysentriae growth in vitro is needed. Objectives: The goal of this research is demonstrate the effect of sea cucumber (Holoturia scabra) to the growth of the Shigella dysentriae bacteria in vitro. Method: The method in this research is Posttest Only Control Group. There are 6 groups, 4 types of and 2 control groups. The concentration of the treatment group is 100%,50%, 25%, and, 12.5% while for positive control tests using chloramphenicol and aquadest as a negative control. Result: The result showed there is an influence on the intake of sand cucumber to the growth of the Shigella dysenteriae. Conclusion: Sea cucumber (Holoturia scabra) inhibit the growth of Shigella dysenteriae.
The Effect of Black Cumin Seed (Nigella sativa l.) Extract to Alloxan Induces Pancreatic Tissue Catalase Enzyme Activity of Male Wistar Rats (Rattus norvegicus) Qonita Achmad; Irmawati Dikman; Sulistiana Prabowo
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 7, No 1 (2018): edisi Maret 2018
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (704.801 KB) | DOI: 10.30742/jikw.v7i1.314

Abstract

Alloxan causes the formation of reactive oxygen through the reduction process of alloxan (dialuric acid) in the β cells of pancreas. Free radicals cause damage  and decrease catalase enzyme activity. Black cumin seeds extract which contain carotenoids, thymoquinone, carvacrol, 4-terpineol, t-anethole, and tert-butylhydroquinone (TBHQ) has antioxidant activity that is expected to inhibit reactive oxygen species (ROS) that is expected to increase pancreatic catalase activity. This study used 24 male Wistar rats, divided into 3 groups:1)group of rats fed with standard food, 2)group of rats induced by alloxan 125mg/kg /BB intraperitoneally on day 1, 3)groups of rats induced by alloxan 125mg/kg/BB intraperitoneally on day 1 and were given by black cumin seed extract 2500mg/kg/BB orally on day 4 until 17. On the 18th day of all rats were sacrificed and pancreatic tissue catalase activity were measured by the spectrophotometric method. The results of One-Way ANOVA showed significant difference (p=0.003) pancreatic tissue catalase activity of groups of rats fed with standard food (1696,96U/g±414,10U/g) compared with group of rats induced by alloxan (1287,58U/g±88,45U/g). There was significant difference (p=0.001) of pancreatic tissue catalase activity of groups of rats induced by alloxan (1287,58U/g±88,45U/g) with a group of rats induced by alloxan and given with black cumin seed extract (1764,83U/g±199,69U/g). The conclusion of this study showed that the administration of alloxan significantly decreased pancreatic tissue catalase activity of rat and black cumin seed extract significantly increased catalase activity because cumin extract has antioxidant effects.
Co-Authors FERIZAL NEGERI SAMUDRA Muhammad Reyhan Arsya Prawesty Diah Utami Qonita Achmad Retno Budiarti SULISTIANA PRABOWO