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A Case Report :Alprazolam Therapy in A Dextra Fronto-Parietal Meningioma Patient With Anxiety Disorders Prajogo Wibowo; Prawesty Diah Utami
Medicra (Journal of Medical Laboratory Science/Technology) Vol 4 No 1 (2021): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v4i1.1409

Meningiomas in the frontoparietal lobe may cause anxiety disorders and panic attacks. While alprazolam is one of the most widely used medications for anxiety disorders, long-term use may result in adverse side effects (withdrawal and rebound effects). This case study aims to describe the efficacy of long-term alprazolam administration in patients with meningiomas for regulating anxiety disorders. Case report :The asymmetrical face is the primary concern of a 65-year-old female when she is anxious. The results of the physical assessment and laboratory tests are within normal ranges. However, The HARS procedure showed moderate anxiety, and the CT scan revealed a meningioma in the right frontoparietal lobe. To regulate patient anxiety disorders, doctors give alprazolam 0.5 mg per day single dose for 4 months and tapering off for 3 months. Conclusion: Long-term administration of alprazolam in these patients can reduce the patient's anxiety disorder without causing withdrawal or rebound effects. A low dosage of alprazolam, a mild level of anxiety illness, and a slow tapering off phase were factors that contributed to the effectiveness of alprazolam treatment to suppress anxiety symptoms in this situation.

Comparison of Cerebral Malaria Mice Models Infected by P. berghei ANKA Prawesty Diah Utami; R. Varidianto Yudo Tjahjono; Indi Jazilah; Ismy Azizah Sisnawati
Denta Journal Kedokteran Gigi Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

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The high morbidity and mortality due to malaria infection makes it a global health problem. The pathogenesis and pathophysiology of cerebral malaria has not been fully understood. The use of cerebral malaria model mice is one alternative to understand its pathogenesis and pathophysiology. The purpose of this study was to compare Swiss mice and C57BL / 6 mice inoculated by P.berghei ANKA as a model of cerebral malaria mice. Methods: The study design was a randomized Post Test Control Only Group Design using 12 Swiss mice and 12 C57BL / 6 mice divided into 2 groups each: the treatment group inoculated by P. berghei ANKA and the control group without inoculation. Observation of clinical manifestations and parasitemia level was carried out from day 1 to day -10. The study results showed that K2 group showed a significant increase in the degree of parasitemia compared to K4. K4 group showed clinical manifestations of cerebral malaria while K2 did not show clinical manifestations of cerebral malaria. Conclusion: C57BL / 6 mice inoculated by PbA can be used as cerebral malaria animal models.

Pengaruh Pemberian Ekstrak Rimpang Temulawak (Curcuma xanthorrhiza Roxb.) Terhadap Jumlah Eritrosit Mencit (Mus musculus L.) Jantan BALB/c yang Diinokulasi Plasmodium Berghei Anka AZARINE NEIRA AVISHA; PRAWESTY DIAH UTAMI
HANG TUAH MEDICAL JOURNAL Vol 15 No 2 (2018): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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ABSTRACT Malaria is still one of the most important infectious diseases in tropical countries because it can cause severe anemia and death. Nowadays, the choice for treatment of malaria is increasingly limited due to drug resistance. Hence, require the invention of new compounds to overcome them. The objective of this research was to perceive the effect of curcuma (Curcuma xanthorrhiza Roxb.) rhizome extract to the amount of erythrocytes in male BALB/c mice (Mus musculus L.) inoculated by Plasmodium berghei ANKA. This research was conducted experimentally with post-test only control group design using five groups of mice. One group was left normal while the other four groups were inoculated with Plasmodium berghei ANKA. From the groups inoculated with Plasmodium berghei ANKA, one group was given aquades and three other groups treated with curcuma (Curcuma xanthorrhiza Roxb.) extract with dose of 150 mg/KgBB, 100 mg/KgBB and 50 mg/KgBB for four days. On the fifth day, a blood test is performed to determine the amount of erythrocytes. The results of this study indicate that the amount of erythrocytesin male BALB/c mice (Mus musculus L.) inoculated byPlasmodium berghei ANKA and given rhizomesextract (Curcuma xanthorrhizaRoxb.) at doses of 150 mg/KgBB and 50 mg/KgBB wereinsignificantly decreased. Whereas the amount of erythrocytesin male BALB/c mice (Mus musculus L.) inoculated byPlasmodium berghei ANKA and given rhizomesextract (Curcuma xanthorrhiza Roxb.) at doses of 100 mg/KgBB weresignificantly decreased

Pengaruh Pemberian Ekstrak Temulawak (Curcuma Xanthorrizha Roxb.) Terhadap Level Nekrosis Pada Jaringan Lien Mencit Putih (Mus Musculus L.) Jantan Galur Balb/c yang Diinokulasi Plasmodium berghei ANKA Muhammad Reyhan Arsya; Prawesty Diah Utami; Irmawati Dikman
HANG TUAH MEDICAL JOURNAL Vol 16 No 2 (2019): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background : Malaria is a disease caused by the Plasmodium, transmitted by Anopheles mosquito and is a health problem in Indonesia. Further development to find new innovations in malaria treatment. Purpose : to determine the effect of temulawak rhizome extract on the level of spleen necrosis of male mice inoculated with Plasmodium berghei ANKA. Methods : a post-test only control group design, used five groups. First group a normal mice, 2nd group was inoculated with Plasmodium berghei ANKA and three treatment groups were inoculated with Plasmodium berghei ANKA and treated with temulawak extract with a dose of 150 mg/KgBB (3rd group), 100 mg/KgBB (4rd group ), and 50 mg/KgBB (5rd group) for four day. On the fifth day observation of the level of spleen necrosis was examination by histopathological Result : the administration of ginger rhizome extract has an influence on the level of necrosis of male mice (Mus musculus L.) BALB / c inoculated with Plasmodium berghei ANKA α = 0,002 (ρ<0,05), where the administration of temulawak extract can increase necrosis levels compared to the control group . This is probably due to the lack of temulawak extract dosage and lack of observation in this study. Conclusion : extract Curcuma xanthorriza Roxb. Has an influence on the level of necrosis of male mice inoculated with Plasmodium berghei ANKA Keywords : Malaria, curcuma (Curcuma xanthorrhiza Roxb.), Necrosis level, Plasmodium berghei ANKA

Comparison of Cerebral Malaria Mice Models Infected by P. berghei ANKA Prawesty Diah Utami; R. Varidianto Yudo Tjahjono; Indi Jazilah; Ismy Azizah Sisnawati
Oceana Biomedicina Journal Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i2.49

The high morbidity and mortality due to malaria infection makes it a global health problem. The pathogenesis and pathophysiology of cerebral malaria has not been fully understood. The use of cerebral malaria model mice is one alternative to understand its pathogenesis and pathophysiology. The purpose of this study was to compare Swiss mice and C57BL / 6 mice inoculated by P.berghei ANKA as a model of cerebral malaria mice. Methods: The study design was a randomized Post Test Control Only Group Design using 12 Swiss mice and 12 C57BL / 6 mice divided into 2 groups each: the treatment group inoculated by P. berghei ANKA and the control group without inoculation. Observation of clinical manifestations and parasitemia level was carried out from day 1 to day -10. The study results showed that K2 group showed a significant increase in the degree of parasitemia compared to K4. K4 group showed clinical manifestations of cerebral malaria while K2 did not show clinical manifestations of cerebral malaria. Conclusion: C57BL / 6 mice inoculated by PbA can be used as cerebral malaria animal models.

Hubungan Status Gizi Pasien Penyakit Hirschsprung dengan Infeksi Luka Operasi di RSPAL dr. Ramelan Surabaya Periode Waktu 2016-2020 PUTU SITHA AISHWARYA SARASWATI GIUR Giur; SAPTA PRIHARTONO RACHMAN; DIAH PURWANINGSARI; PRAWESTY DIAH UTAMI
HANG TUAH MEDICAL JOURNAL Vol 20 No 1 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v20i1.279

Background: Hirschsprung's disease is a congenital intestinal motility disorder that causes functional intestinal obstruction due to the absence of enteric ganglion cells in the distal intestine. The management of each case of Hirschsprung's disease is surgery, where surgery on the digestive tract increases the occurrence of surgical site infections. Disturbances in the gut cause decreased resistance to infection, delayed cognitive development, and problems with nutritional status. Methods: This study was a descriptive and analytical observational study, where the primary data were taken from the registration data of Hirschprung's disease patients at RSPAL dr. Ramelan Surabaya in 2016-2020. The nutritional status of the patient was determined by plotting the weight per age curve according to WHO for children aged 0-5 years. Results: Observations of 38 patients who met the study requirements, obtained 4 patients who had poor nutritional status and 1 patient who had excess nutritional status, none of which experienced complications in the form of surgical wound infections. In 10 patients with poor nutritional status, 2 experienced complications in the form of surgical wound infection and 23 patients with good nutritional status, 1 experienced complications in the form of surgical wound infection. The results of the contingency coefficient correlation test showed P-value = 0.408 (p>α). Conclusion: There was no relationship between the nutritional status of Hirschprung's disease patients with surgical wound infections at RSPAL dr. Ramelan Surabaya Keywords: Hirschsprung's disease, nutritional status of children, surgical site infection.

Efek Pemberian Oksigen Hiperbarik Pada Efektivitas Ekstrak Cacing Tanah (Lumbricus terrestris) Terhadap Pertumbuhan Salmonella Typhi Secara In Vitro VARIDIANTO YUDO TJAHJONO; RETNO BUDIARTI; PRAWESTY DIAH UTAMI
HANG TUAH MEDICAL JOURNAL Vol 20 No 1 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v20i1.341

Background: Typhoid fever is an infectious disease of the small intestine caused by the bacterium Salmonella typhi, and causes a fairly high mortality rate. These bacteria have developed resistance to many antibiotics. Earthworm extract (ECT) has been widely used as an alternative to treat typhoid fever. Hyperbaric oxygen therapy (OHB) has been used to treat various diseases and can suppress the growth of bacteria. Objective: To determine the effect of hyperbaric oxygen (OHB) 3 ATA on the effectiveness of earthworm (Lumbricus terrestris) extract on the growth of Salmonella typhi in vitro. Methods: This experimental study used the post-test only control group design method. Thirty-six samples of S.typhi bacteria in liquid medium (broth) were divided into four groups. The first group (K-) was not given any treatment, the second group (P1) was given earthworm extract, the third group (P2) was given hyperbaric oxygen 3 ATA, and the fourth group (P3) was given a combination of earthworm extract and hyperbaric oxygen 3 ATA. The results of bacterial growth in each group were calculated in colony forming units (CFU) / ml and analyzed statistically. Results: The growth of S.typhi bacteria in the first group (K-) was 108.51 x 106 CFU/ml, the second group (P1) was 483 CFU/ml, the third group was 1.4 x 106 CFU/ml, and the fourth group (P3) was 215 CFU/ml. The fourth group (P3) had the smallest number of bacterial growth and had a significant difference compared to the first (P1) and third (P3) groups (p = 0.001; p < α ; α = 0.05), but the difference was not significant compared to the second group (P1 ) (p = 0.308; p > α; α = 0.05). Conclusion: Giving earthworm extract (ECT) with hyperbaric oxygen (OHB) 3 ATA (combination) was most effective in inhibiting the growth of Salmonella typhi bacteria compared to giving earthworm extract (ECT) alone or giving hyperbaric oxygen (OHB) 3 ATA alone.

Pengaruh Diet Ketogenik terhadap C-Reactive Protein dan Glasgow Prognostic Score pada Pasien Kanker Payudara Metastatik (Uji Klinis Fase 2) Anang Mufti; Prawesty Diah Utami
Surabaya Biomedical Journal Vol 1 No 2 (2022): Januari
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i2.14

Abstrak Bahan pembentuk energi utama bagi sel kanker berupa glukosa dengan residual laktat yang tinggi akibat efek Warburg. Diet ketogenik akan merubah sumber energi dari glukosa menjadi badan keton, sehingga sel kanker akan mengalami reaksi inflamasi dan kelaparan. Pada pasien kanker payudara metastatik yang belum mendapatkan terapi onkologi spesifik, inflamasi sistemik yang terjadi dapat diukur dengan serum C-Reactive Protein (CRP) dan skor inflamasi sistemik menggunakan Glasgow Prognostic Score (GPS) modified. GPS merupakan salah satu faktor. prediktor independen kelangsungan hidup. Pelaksanaan penelitian ini diawali pada Februari sampai Juli 2018 di Unit Rawat Jalan Bedah Onkologi RSUP Dr. Saiful Anwar Malang, Indonesia. Pada subyek penelitian terjadi penurunan kadar CRP serum yang menunjukkan nilai signifikan sebesar 0,020 (< 0,050) dengan penurunan nilai persentase sebesar 21,1% (>20%). Terjadi pula penurunan skor GPS/mGPS yang menunjukkan nilai signifikan sebesar 0,011 (< 0,050). Abstract The main energy-forming material for cancer cells is glucose with high residual lactate due to the Warburg effect. By converting the energy source from glucose to ketone bodies through a ketogenic diet, cancer cells will experience inflammatory reactions and starvation. For patients with metastatic breast cancer who haven't already obtained specific oncology therapy, the systemic inflammation that occurs can be measured by serum C-Reactive Protein (CRP) and systemic inflammatory scores using the Glasgow Prognostic Score (GPS)/modified GPS, which is a one-factor independent predictor of survival. The implementation of this research started from February to July 2018 at the Outpatient Unit of Surgical Oncology of Dr. Saiful Anwar General Hospital, Malang, Indonesia. In the study subjects, there was a decrease in serum CRP levels which showed a significant value of 0.020 (< 0.050) with a reduction in the percentage value of 21.1% (> 20%). There was also a decrease in the GPS/mGPS score, which showed a significant value of 0.011 (< 0.050).

STUDI EKSPERIMENTAL: PENURUNAN PROFIL NETROFIL DAN TNF-α SETELAH PEMBERIAN EKSTRAK TERIPANG EMAS (STICHOPUS HERMANNI) R. Varidianto Yudo Tjahjono; Prawesty Diah Utami; Herin Setianingsih
Surabaya Biomedical Journal Vol 1 No 2 (2022): Januari
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i2.23

Latar Belakang: Vaginitis candida adalah penyakit infeksi jamur yang diderita hampir setiap wanita di dunia. Meningkatnya jumlah netrofil dan kadar faktor nekrosis tumor alfa (TNF-α) merupakan ciri khas dari penyakit ini. Ekstrak teripang emas (Stichopus hermanni) telah banyak diteliti terutama untuk anti jamur dan bakteri, anti peradangan , anti oksidan dan lain-lain. Tujuan: Membandingkan profil netrofil dan TNF-α antara kelompok kontrol dengan kelompok studi lain yang mendapatkan ekstrak teripang emas (S.hermanni) melalui studi eksperimental menggunakan mencit coba. Metode: Penelitian eksperimental dengan desain “post-test only control group design”. Unit eksperimentalnya terdiri dari 24 mencit BALB/c yang diinokulasi C.albicans per vaginam dan dibagi menjadi empat grup terdiri dari : (K-) kelompok yang tidak mendapatkan perlakuan; (P1)kelompok yang mendapatkan ekstrak S.hermanni dosis 8,5mg/kgBB; (P2) kelompok dengan dosis ekstrak 17mg/kgBB; dan (P3) kelompok dengan dosis ektrak 34 mg/kgBB. Jumlah netrofil dilihat dari pemeriksaan mikroskopis jaringan mukosa vagina. Kadar sitokin TNF-α dilihat dari pemeriksaan ELISA sampel darah. Hasil: Hasil pengamatan profil netrofil pada jaringan mukosa vagina mencit coba menunjukkan bahwa kelompok P2 mengalami penurunan netrofil tertinggi namun secara statistic tidak signifikan penurunannya (p=0,156; p>α). Pengamatan profil TNF-α padai serum darah mencit pada kelompok P2 menunukkan penurunan yang signifikan dibanding kelompk lain (p=0,001; p< α). Perbedaan ini terutama bila dibandingkan kelompok K- (p=0,004; p< α) dan kelompok P1(p=0,004; p< α) Kesimpulan: Pemberian ekstrak S.hermanni terbukti mampu menurunkan profil netrofil dan kadar TNF-α pada mencit coba, dengan dosis efektifnya sebesar 17 mg/kgBB.

STUDI IN VITRO: PENGARUH PEMBERIAN EKSTRAK Holothuria athra DENGAN PELARUT N-HEKSANA TERHADAP PERTUMBUHAN Plasmodium falciparum Prawesty Diah Utami
Surabaya Biomedical Journal Vol 1 No 3 (2022): Mei
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i3.30

Malaria adalah penyakit yang disebabkan oleh Plasmodium yang ditularkan nyamuk Anopheles betina infektif. Teripang keling (Holothuria atra) adalah biota laut yang mengandung berbagai komponen bioaktif yaitu alkaloid, flavonoid, saponin dan terpenoid sebagai antimalaria. Penelitian dilakukan untuk mengetahui pengaruh pemberian ekstrak teripang keling (Holothuria athra) terhadap pertumbuhan P. falciparum berdasarkan studi in vitro. Penelitian ini menggunakan sampel kultur P.falciparum strain 3D7 dan ekstrak H.atra yang diberikan pelarut n-heksana. Media kultur dibagi menjadi 3 kelompok kontrol yaitu kontrol negatif, kontrol positif dan dengan penambahan ekstrak H.atra pelarut n-heksana. Ketiga kelompok kontrol ini akan di inkubasi selama 48 jam pada suhu 37o C. Setelah itu dilakukan pemeriksaan kadar pemeriksaan kadar parasitemia dan inhibitory rate menggunakan mikroskop cahaya serta pengukuran IC50 menggunakan analisis probit melalui program SPSS. Pada penelitian ini memperlihatkan adanya efek antimalaria dalam menghambat pertumbuhan P.falciparum. Semakin besar dosis yang diberikan maka efek hambatannya juga semakin besar. Nilai IC50 ekstrak n-heksana H.atra adalah 1,23 µg/ml. Dari hasil analisis membuktikan bahwa ekstrak teripang keling (Holothuria atra) dengan pelarut N-heksana memiliki efek antimalaria yang dapat menghambat pertumbuhan P.falciparum dan mempunyai aktivitas yang tinggi sebagai antimalaria.

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