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Rais Razak
Faculty of Pharmacy, Universitas Muslim Indonesia, Makassar
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Sulfonamide Residue in the Broiler Chicken Circulating in Makassar Muammar Fawwaz; Rais Razak; Masdiana Tahir; Andi Permatasari; Andi Tenri Amula; Seniwati Seniwati
Pharmaceutical Reports Vol 1, No 2 (2022): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (443.376 KB) | DOI: 10.33096/pharm rep.v1i2.169

Abstract

The use of sulfonamide related to drug residual in the product of broiler chicken, like meat and egg. This research aimed to determine the sulfonamides (sulfamerazine, sulfanilamide, and sulfadiazine) on the broiler chicken meat, breast, and egg from the three different slaughterhouses circulating in the City of Makassar. The sample was extracted by acetonitrile and acetone then concentrated. The extract and sulfonamides then analyzed by HPLC method using C18 reverse phased column, UV-Visible detector in the wavelength of 270 nm. The result of study shows that the chromatogram of sample breast and egg has similar retention time with sulfonamides as a standard reference. The breast sample contains sulfamerazine residues, sample B and C contains 0.014 and 0.005 % (w/w), respectively. The egg sample A and D contains sulfadiazine 0.045 and 0.108 % (w/w), respectively. Sample B contains sulfanilamide 0.053 % (w/w). Sample A and B is egg yolk, while sample D is egg whites. Based on the results obtained, this is not suitable for the rules set by JECFA of 0.1 mg/kg (10-5 % w/w) as well as the standard of SNI. It can be concluded that generally broiler chicken breast and egg circulating in the City of Makassar was contaminated by sulfonamide with high concentration.
In Vitro Activity Test of A-Glucosidase Enzyme Inhibition of Moringa oleifera L. Leaves Extract Irma Pattola; St. Maryam; Rais Razak
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (184.834 KB) | DOI: 10.33096/pharm rep.v1i1.155

Abstract

Diabetes Mellitus (DM) is a group of disease characterized by an increase in insulin. Moringa oleifera leaves contain chemical properties such as tannins, steroids, triterpenes, flavonoids, saponins, anthraquinones and alkaloids. These chemical compounds can affect a variety of biological activities and one of the is antidiabetic. The research aimed to study the potential of Moringa oleifera extract in relation to the a-glucosidase enzyme which is one of the transitions of antidiabetic drugs based on IC50 values. In this study moringa leaves were extracted by maceration method using 96% ethanol solvent. The inhibitory activity testing uses an ELISA (Enzyme-linked Immunosorbent Assay) reader measured at 405 nm wavelength with a comparator of the acarbose because it is an antidiabetic drug of the glucosidase enzyme inhibitor group. The results of the a-glucosidase enzyme showed that the a-glucosidase enzyme activity was inhibited by the ethanol extract of Moringa oleifera L. with C50 value 84,238 µg/mL included in the less active category.
Co-Authors Andi Permatasari Andi Tenri Amula Irma Pattola Masdiana Tahir Muammar Fawwaz Seniwati Seniwati, Seniwati St. Maryam