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Lilik Koernia Wahidah
Program Studi Farmasi Universitas Tulang Bawang
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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POTENSI INTERAKSI OBAT PADA PASIEN GASTRITIS DI PUSKESMAS RAWAT INAP WAY KANDIS BANDAR LAMPUNG TAHUN 2020 Lilik Koernia Wahidah; Novita Tri Wahyuni; Cahya Rizky Amaliana
JFL : Jurnal Farmasi Lampung Vol. 10 No. 2 (2021): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v10i2.702

Abstract

ABSTRACT Gastritis is an inflammatory process in the mucous and sub-mucous layers of the stomach. The use of several drugs simultaneously facilitates the occurrence of drug interactions that are part of the Drug Related Problem (DRPs). This study aims to determine the potential for drug interactions in gastritis patients at the Puskesmas Rawat Inap Way Kandis Bandar Lampung in 2020. The research method carried out is observational research with a descriptive design taken retrospectively. The results of the study based on gender showed that there were 34 male patients (40.5%) and 50 female patients (59.5%). Then, based on the age group of 17-25 years, there were 26 patients (31%), aged 26-35 years as many as 16 patients (19%), aged 36-45 as many as 19 patients (22.6%), aged 46-55 as many as 13 patients (15.5%), aged 56-65 as many as 5 patients (6%), and aged >65 years as many as 5 patients (6%). The most use of gastritis drugs are antacids (92.8%), omeprazole (21.4%), ranitidine (15.1%). Drug interactions based on pharmacokinetic mechanisms were 20 cases (58.8%), and pharmacodynamic mechanisms were 14 cases (41.1%). Severity, 18 cases (52.9%) minor, 14 cases (41.1%) moderate, and 2 cases (5.8%) major. It was concluded that the potential drug interactions that experienced the incidence of drug interactions were 27 samples (32.1%) and 57 samples (67.8%) did not experience drug interactions.  Keywords : Antacids, DRPs, Drug Interactions, Gastritis, Omeprazole, Ranitidine
IDENTIFIKASI DRUG RELATED PROBLEMS (DRPs) PENGGUNAAN ANTIHIPERTENSI PASIEN HIPERTENSI DI RSU AZZAHRA KALIREJO LAMPUNG TENGAH Lilik Koernia Wahidah; Novita Tri Wahyuni; Desiamti Ughfiroh
JFL : Jurnal Farmasi Lampung Vol. 11 No. 1 (2022): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v11i1.715

Abstract

A person is diagnosed with hypertension if there is an increase in systolic blood 140 mmHg and diastolic blood pressure 90 mmHg. Treatment of hypertension aims to reduce morbidity and mortality. Hypertensive patients receiving polypharmacy pharmacological therapy are at risk of developing DRPs. The purpose of this study was to identify the incidence of Drug Related Problems (DRPs) in the use of antihypertensives in hypertensive patients at Azzahra Kalirejo General Hospital, Central Lampung in 2021. This study was non-experimental with a retrospective descriptive design, then identified using the classification of DRPs according to Robert J. Cipolle EL. Pharmaceutical Care Practice and Medscape and Drug Interaction Chacker applications to identify drug interactions, and use the Medication Possession Ratio (MPR) formula to identify patient non-compliance. Based on the results of research at Azzahra Kalirejo General Hospital, Central Lampung, of the 135 samples that met the inclusion criteria, 80% of the samples experienced DRPs. Based on gender characteristics, there were 50.37% male and 49.62% female with 0% of patients aged <25 years, age 26-45 years 30.3%, age 46-65 years 57.8% and age > 65 years 11.8%. The most widely prescribed antihypertensive drug was furosemide as much as 42.2%, the most antihypertensive combination was a combination of two drugs as much as 57%. The most use of non antihypertensive drugs is PPI and analgesics as much as 12.8%. Cases of DRPs requiring additional therapy were 1.9%, drug therapy was not necessary 7.4% cases, inappropriate drugs 4.6% cases, doses too low and high in 0% cases, drug interactions were 77.8% with major severity 11.7%, minor 34.5% cases and moderate as many as 53.7%, patient non-compliance with DRPs occurred in 51.9% cases.  Keywords:  Antihipertensive, DRPs, Furosemide, Hypertension
POTENSI INTERAKSI OBAT PADA PERESEPAN PASIEN GERIATRI RAWAT JALAN DI PUSKESMAS SATELIT BANDAR LAMPUNG TAHUN 2021 Hijrah Hijrah; Lilik Koernia Wahidah; Ayu Herawati; Adityo Adityo
JFL : Jurnal Farmasi Lampung Vol. 11 No. 1 (2022): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v11i1.741

Abstract

Drug interaction is the modification of the effect of a drug due to a drug being given alongside food, drinks or other drugs so that the effectiveness or toxicity of a drug changes. Some of the drugs prescribed in geriatric patients need to be considered so that no adverse drug interactions occur. This study aims to determine the potential for drug interactions in the prescribing of outpatient geriatric patients at the Bandar Lampung City Satellite Health Center in the 2021 period. This study is a non-experimental type with a descriptive design taken retrospectively. Sampling using purposive sampling method. The instruments in this study were medical records and prescriptions of geriatric patients, using the Drugs.com and Medscape applications. The results of this study showed that out of 256 prescriptions for geriatric patients there were 138 prescriptions (53.9%) who experienced drug interactions, with 120 male sex patients (46.9%) and female sex as many as 136 patients (53,1%). Based on the age category of 56-65 there were 110 patients (43%), aged 66-75 there were 120 patients (47%), and aged 76-90 there were 26 patients (10%). Drug interaction levels were minor category 51 patients (24.1%), moderate 140 patients (66.0%), and major 21 patients (9.9%). Based on the mechanism of pharmacodynamic interactions of 183 (86.3%) and pharmacokinetic interactions of 28 (13.7%). The conclusions of this study prove drugs administered to geriatric patients can cause drug interactions. Keywords : Drug Interactions, Geriatric, Prescription
STUDI FARMAKOVIGILAN OBAT ANTIHIPERTENSI PADA PASIEN HIPERTENSI RAWAT JALAN DI DR. A. DADI TJOKRODIPO BANDAR LAMPUNG PERIODE OKTOBER–NOVEMBER 2021 Lilik Koernia Wahidah; Novita Tri Wahyuni; Dion Yongtama
JFL : Jurnal Farmasi Lampung Vol. 11 No. 2 (2022): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v11i2.814

Abstract

Hypertension, also known as high blood pressure, is systolic pressure140 and diastolic pressure 80 mmHg. The more blood pressure is pumped by the heart and the narrower the arteries, the higher the blood pressure. This study aims to determine the occurrence of adverse drug reactions in hypertensive patients in RSD DR. A. Dadi Tjokrodipo Bandar Lampung. This research is a descriptive research with total sampling method. Collecting data by looking at the patient's medical record data. The results showed that the female sex was more dominant in suffering from hypertension, namely 20 female patients (62.5%) and 12 male patients (37.5%). The highest age characteristics were found in the age range of 46-55 years as many as 14 patients (43.75%). The most characteristic of hypertension was in the case of stage 2 hypertension with a total of 17 patients (53.12%). The highest pattern of drug use was amlodipine (37.5%). The incidence of drug interactions was 10 cases (31.25%) with minor severity. The highest incidence of ADR was in the "moderately probable" 1-4 with a total of 15 cases (46.87%). Keywords: ADR, hypertension, drug interactions, antihypertensive drugs
PENETAPAN NILAI SPF (SUN PROTECTION FACTOR) SEDIAAN KRIM TABIR SURYA DI KOTA BANDAR LAMPUNG DENGAN METODE SPEKTROFOTOMETRI UV-VIS Subur Widodo; Akhmad Rokiban; Lilik Koernia Wahidah; Ikhrami Nurjannah
JFL : Jurnal Farmasi Lampung Vol. 12 No. 1 (2023): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v12i1.978

Abstract

Nowadays people awareness of the healthy skin importance is increasing, this is evident by the increasing cosmetic brands and there are many beauty clinics. Cosmetic products marketed should have the same efficacy as those listed on the packaging. Therefore, determining the efficacy of sunscreen preparations is very important to see the compliance of cosmetics manufacturers. The purpose of this study was to determine the suitability of the SPF product efficacy. The samples are the products which have SPF 30, the sample was tested by in vitro method using UV-Vis spectrophotometer, every 5 nm with the wavelength range 290 nm - 320 nm absorbance was measured, then analyzed with the mansur equation. Also did antioxidant activity tested with vitamin C as a control positive using the DPPH method. The principle of the DPPH method is the measurement of absorbance of DPPH radicals which are degraded due to the presence of antioxidant compounds using a UV-Vis spectrophotometer. The decrease in DPPH absorbance intensity is proportional to the increase in the concentration of antioxidant compounds expressed in IC50 (Inhibition Concentration 50). Sample 4 has an SPF value close to the value written on the packaging. Samples 2, 5, 1, 3, 6, 7 and 8 have SPF values ​​smaller than those listed on the packaging. The antioxidant activity obtained is rateable to the SPF value, sample 4 has the highest antioxidant activity followed by sample 2, sample 5, sample 1, sample 3, sample 6, and sample 7 and sample 8 have the lowest antioxidant activity. Keywords: Antioxidant , DPPH, UV-Vis spectrophotometry, SPF, Sunscreen
Co-Authors Adityo Adityo Ayu Herawati Cahya Rizky Amaliana Desiamti Ughfiroh Dion Yongtama Hijrah Hijrah Ikhrami Nurjannah Novita Tri Wahyuni Rokiban, Akhmad Subur Widodo