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All Journal JFL : Jurnal Farmasi Lampung
Subur Widodo
Program Studi Farmasi Universitas Tulang Bawang
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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UJI EFEK STIMULAN FRAKSI N-HEKSAN DAUN PEGAGAN (Centella asiatica (L.)Urban) Nurma Suri; Subur Widodo; Mega Intan Yulianti
JFL : Jurnal Farmasi Lampung Vol. 10 No. 2 (2021): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v10i2.703

Abstract

Abstract Current condition related to fulfilling stimulating in the societies is by energy drinks and vitamins which have side effects restless, nervous, tremor, and seizures. Alternative stimulant can derived from herbs. One of the plants has potention of stimulant is Centella asiatica. This study was to examine the effect of stimulant on fraction n-hexane of C.asiatica leaves. The simplisia of C.asiatica leaves was extracted with ethanol 70% using a maceration method. Thereafter, extract was fractionated using n-hexane. Phytochemical screening was carried out to determine the content of secondary metabolites in order to find out the potential utilization by testing the active compounds. Stimulant effect was evaluated using induced sleeping time, swimming endurance time, hanging time, and rotarod method with the dose 2.59 mg/KgBW, 5.185mg/KgBW, 10.37 mg/KgBW, and 15.55 mg/KgBW, caffeine as the positive control, and Na-CMC as the negative control. The phytochemical screening showed positive results for triterpenoids and alcaloid. All of the dose fraction n-hexane had effect stimulant however dose 5.185 mg/KgBW and 10.37 mg/KgBW had as same stimulant effect as positive control and dose15.55 mg/BW had higher stimulant effect. N-hexane fractionation of C.asiatica leaves demonstrated the presence of secondary metabolites with potential biological activities as stimulant. Keywords: Alkaloids, C. asiatica, Triterpenoids, Stimulants test
PENETAPAN NILAI SPF (SUN PROTECTION FACTOR) SEDIAAN KRIM TABIR SURYA DI KOTA BANDAR LAMPUNG DENGAN METODE SPEKTROFOTOMETRI UV-VIS Subur Widodo; Akhmad Rokiban; Lilik Koernia Wahidah; Ikhrami Nurjannah
JFL : Jurnal Farmasi Lampung Vol. 12 No. 1 (2023): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v12i1.978

Abstract

Nowadays people awareness of the healthy skin importance is increasing, this is evident by the increasing cosmetic brands and there are many beauty clinics. Cosmetic products marketed should have the same efficacy as those listed on the packaging. Therefore, determining the efficacy of sunscreen preparations is very important to see the compliance of cosmetics manufacturers. The purpose of this study was to determine the suitability of the SPF product efficacy. The samples are the products which have SPF 30, the sample was tested by in vitro method using UV-Vis spectrophotometer, every 5 nm with the wavelength range 290 nm - 320 nm absorbance was measured, then analyzed with the mansur equation. Also did antioxidant activity tested with vitamin C as a control positive using the DPPH method. The principle of the DPPH method is the measurement of absorbance of DPPH radicals which are degraded due to the presence of antioxidant compounds using a UV-Vis spectrophotometer. The decrease in DPPH absorbance intensity is proportional to the increase in the concentration of antioxidant compounds expressed in IC50 (Inhibition Concentration 50). Sample 4 has an SPF value close to the value written on the packaging. Samples 2, 5, 1, 3, 6, 7 and 8 have SPF values ​​smaller than those listed on the packaging. The antioxidant activity obtained is rateable to the SPF value, sample 4 has the highest antioxidant activity followed by sample 2, sample 5, sample 1, sample 3, sample 6, and sample 7 and sample 8 have the lowest antioxidant activity. Keywords: Antioxidant , DPPH, UV-Vis spectrophotometry, SPF, Sunscreen
Co-Authors Akhmad Rokiban Ikhrami Nurjannah Lilik Koernia Wahidah Mega Intan Yulianti Nurma Suri