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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Edyson Edyson
Universitas Lambung Mangkurat
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Homeostasis: Jurnal Mahasiswa Pendidikan Dokter

 1 
Perbandingan Aktivitas Daya Hambat Sediaan Tunggal dengan Kombinasi Infus Phyllantus niruri dan Peperomia pellucida terhadap Salmonella typhi Thea Shagita; Lia Yulia Budiarti; Edyson Edyson
Homeostasis Vol 3, No 1 (2020)
Publisher : Homeostasis

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Abstract: Phyllantus niruri (meniran) and Peperomia pellucida (sirih cina) are traditional medicine which contain the chemical compounds that is act as antibacterial agent. Meniran contains various chemical compounds like flavonoid, alkaloid, and tanin,  whereas in sirih cina are flavonoid and alkaloid. This study aims to compare the inhibitory activity of single concentration treatments with a combination of meniran and sirih cina infusion on the Salmonella typhi in vitro. Data analysis was performed by One-way ANOVA test and Duncan post-hoc test (ɑ<0,05). The result showed that there where significant difference from each treatment of single and combination dose infusion of Phyllantus niruri and Peperomia pellucida. In conclusion, the single and combination dose of meniran and sirih cina does not have the optimum inhibitory activity againts S. typhi. Keywords: Phyllantus niruri, Peperomia pellucida, Salmonella typhi, single dose, combination dose, inhibitory zone. Abstrak: Phyllantus niruri (meniran) dan Peperomia pellucida (sirih cina) merupakan tanaman obat yang mempunyai kandungan zat aktif yang bersifat antibakteri. Tanaman meniran mengandung zat aktif flavonoid, alkaloid, dan tanin, sedangkan sirih cina mengandung zat aktif flavonoid dan alkaloid. Penelitian ini bertujuan untuk membandingkan aktivitas daya hambat dari sediaan tunggal dan kombinasi infus meniran dan sirih cina terhadap Salmonella typhi secara in vitro. Analisis data menggunakan uji One-way anova dan uji post-hoc Duncan (ɑ<0,05). Hasil penelitian didapatkan perbedaan bermakna dari masing-masing perlakuan sediaan tunggal dan kombinasi infus meniran dan sirih cina. Kesimpulan dari penelitian ini adalah sediaan tunggal maupun kombinasi infus meniran dan sirih cina belum dapat menghambat pertumbuhan S. typhi secara optimum. Kata-kata kunci: Phyllantus niruri, Peperomia pellucida, Salmonella typhi, sediaan tunggal, sediaan kombinasi, zona hambat.
AKTIVITAS DAYA HAMBAT EKTRAK ETANOL DAUN BINJAI (Mangifera caesia Jack) TERHADAP Salmonella typhi DAN Shigella dysentriae IN VITRO Hikmah Ika Darmayanta; Edyson Edyson; Lia Yulia Budiarti
Homeostasis Vol 2, No 2 (2019)
Publisher : Homeostasis

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Abstract: Binjai is one of the typical plants of South Kalimantan which is known to have the efficacy as a medicinal plant to overcome a bacterial infection. The active ingredient of ethanol extract of binjai leaves is saponins, tannins, alkaloids and flavonoids. The purpose of this study was to test the activity of ethanolic extract of binjai leaves against Salmonella typhi ATCC 14028 and Shigella dysentriae ATCC 13313. The design of this study was true experimental with post-test only with control group design consisting of 9 treatments of binjai leaves extract (55%, 60% , 65%, 70%, 75%, 80%, 85%, 90%, 95%) and 15 µg amoxicillin as positive controls. Analysis of research data using One-way ANOVA, Duncan Post-hoc test, and independent T test (α = 0.05). The results showed significant differences in all treatments. Ethanol extract of binjai leaves at a concentration of 85% was the optimum concentration against Salmonella typhi (25.16 mm) and Shigella dysentriae (22.66 mm). The conclusion is the effect of binjai leaves ethanol extract gives a greater average inhibition zone for Salmonella typhi compared to Shigella dysentriae at the same concentration. Keywords: binjai leaves extract, Salmonella typhi, Shigella dysentriae. Abstrak: Binjai merupakan salah satu tumbuhan khas Kalimantan Selatan yang diketahui memiliki khasiat sebagai tanaman obat untuk mengatasi suatu infeksi bakterialis. Kandungan zat aktif dari ekstrak etanol daun binjai adalah saponin, tanin, alkaloid dan flavonoid. Tujuan penelitian ini yaitu menguji aktivitas ekstrak etanol daun binjai terhadap Salmonella typhi ATCC 14028 dan Shigella dysentriae ATCC 13313. Rancangan penelitian ini adalah true experimental dengan post test-only with control group design yang terdiri dari 9 perlakuan ekstrak daun binjai (55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%) dan amoksisilin 15 µg sebagai kontrol positif. Analisis data penelitian menggunakan uji One-way ANOVA, uji Post-hoc Duncan, dan uji T independent (α = 0,05). Hasil penelitian menunjukkan adanya perbedaan bermakna dari semua perlakuan. Ekstrak etanol daun binjai pada konsentrasi 85% merupakan konsentrasi yang optimum terhadap Salmonella typhi (25,16 mm) dan Shigella dysentriae (22,66 mm). Simpulannya adalah efek ektrak etanol daun binjai memberikan rerata besaran zona hambat yang lebih besar terhadap Salmonella typhi dibandingkan dengan Shigella dysentriae pada konsentrasi yang sama. Kata - kata kunci: ekstrak etanol daun binjai, Salmonella typhi, Shigella dysentriae
Perbandingan Aktivitas Daya Hambat Sediaan Tunggal dengan Kombinasi Infus Phyllanthus niruri dan Peperomia pellucida terhadap Escherichia coli Lutfia Papita Derizky Rahmayanti; Edyson Edyson; Lia Yulia Budiarti
Homeostasis Vol 3, No 1 (2020)
Publisher : Homeostasis

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Abstract

Abstract: Phyllanthus niruri (meniran) and Peperomia pellucida (sirih cina) are used by the native people of Borneo as herbal medicines. Alkaloids, anthraquinones, tannins, phenols, terpenoid, flavonoids, and steroids in both herb act as antibacterial substances. Herbal medicine usually consumed in a single or combination preparation. The aim of this study was to analyze the differences in the inhibitory activity of a single and combination of meniran and sirih cina infusion against Escherichia coli (E. coli). True-experimental method with a post-test only with the control group design was used in this study. The concentration of meniran and sirih cina infusion were 10%, 20%, 30%, and 40%. Gentamicin and distilled water are used as positive and negative controls. Data analyzed using the One-Way ANOVA test and the Post-hoc Duncan test (α = 0.05) found significant differences (p <0.05) between single and combination preparations. The largest inhibitory zone was produced by a combination of 20% meniran + 20% sirih cina (19.62 ± 0.40 mm). The synergistic effect was seen in combination preparations which had a greater inhibition zone than a single preparation, but this inhibitory activity was significant differences with gentamicin inhibition zone (22.69 ± 0.03 mm). It was concluded that combination preparation has larger inhibitory zone than a single preparation, but could not produce optimum inhibition against E. coli ATCC 25922. Keywords: Single preparation, combination preparation, Phyllanthus niruri, Peperomia pellucida, Inhibitory activity. Abstrak: Phyllanthus niruri (meniran) dan Peperomia pellucida (sirih cina) dimanfaatkan masyarakat Kalimantan sebagai obat herbal. Alkaloid, antrakuinon, tanin, fenol, terpenoid, flavonoid, dan steroid merupakan kandungan senyawa pada kedua tanaman yang bersifat antibakteri. Selain sediaan tunggal, obat herbal juga dapat digunakan dalam bentuk kombinasi. Penelitian ini bertujuan untuk menganalisis perbedaan aktivitas daya hambat optimum sediaan tunggal dengan kombinasi infus meniran dan sirih cina terhadap Escherichia coli (E. coli). Metode true-experimental dengan rancangan post-test only with control group design digunakan pada penelitian ini. Perlakuan yang digunakan ialah sediaan tunggal dan kombinasi infus meniran dan sirih cina dengan konsentrasi 10%, 20%, 30%, dan 40%. Gentamisin dan akuades digunakan sebagai kontrol positif dan negatif. Data yang dianalisis menggunakan uji One-Way ANOVA dan uji Post-hoc Duncan (α=0,05) ditemukan bahwa hasil antara sediaan tunggal dan kombinasi berbeda bermakna (p<0,05). Zona hambat terbesar dihasilkan oleh sediaan kombinasi meniran 20% + sirih cina 20% (19,62±0,40 mm). Efek sinergis terlihat pada perlakuan sediaan kombinasi yang memiliki zona hambat lebih besar dibanding sediaan tunggal, namun aktivitas daya hambat tersebut masih belum bisa menyamai zona hambat gentamisin (22,69±0,03 mm) berdasarkan uji statistik. Disimpulkan bahwa sediaan kombinasi memiliki zona hambat lebih besar dibanding sediaan tunggal, namun belum dapat menghasilkan daya hambat optimal terhadap E. coli ATCC 25922. Kata-kata kunci: sediaan tunggal, sediaan kombinasi, Phyllanthus niruri, Peperomia pellucida, Escherichia coli, daya hambat.
Perbandingan Aktivitas Daya Hambat Sediaan Tunggal dengan Kombinasi Infus Phyllanthus niruri dan Peperomia pellucida terhadap Staphylococcus aureus Lie Vanny Leono; Edyson Edyson; Lia Yulia Budiarti
Homeostasis Vol 3, No 1 (2020)
Publisher : Homeostasis

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Abstract

Abstract: Phyllanthus niruri and Peperomia pellucida traditionally used for treatment of a variety of diseases. Both of these plants are known to contain compounds that have antibacterial activity name flavonoids, alkaloids, tannins. Medicinal plant consumption can be used singly or in combination. The purpose of this study was to analyze the differences of  optimum inhibitory activity between a single and the combination of infusion of P. niruri and P. pellucida on the growth of S. aureus in vitro. This study method was a true experimental with post test-only design with control group design, consisting of 26 single and combination treatments of P. niruri concentrations at 5%, 15, 25%, 35% and P. pellucida concentration at 10%, 20%, 30 %, 40%. The controls used were vancomycin 30µg and distilled water. The parameter measured is the diameter of the inhibition zone. The data was analyzed used One-way ANOVA test and Duncan's post-hoc test with α = 0.05. The results showed there were significant differences from each treatment of single and combination infusion (p <0.05). The combination of P. niruri and P. pellucida infusion that produces optimum inhibitory zone effect greater than the single preparation found at Meniran 25% + P. pellucida 40%. The conclusion from this study is that the combination infusion have optimum inhibition greater than the single infusion. Keywords: single dose, combination dose, Phyllanthus niruri, Peperomia pellucida, Staphylococcus aureus, optimum inhibitory activity Abstrak: Meniran (Phyllanthus niruri) dan sirih cina (Peperomia pellucida) merupakan tanaman herbal yang digunakan masyarakat untuk mengobati berbagai macam penyakit.  Kedua tanaman ini diketahui mengandung senyawa yang bersifat antibakteri yaitu flavonoid, alkaloid, dan tanin. Sediaan tanaman obat dapat digunakan secara tunggal maupun kombinasi. Tujuan penelitian ini adalah menganalisis perbedaan aktivitas daya hambat optimum dari sediaan tunggal dan kombinasi infus meniran dan sirih cina terhadap pertumbuhan S. aureus secara in vitro. Metode penelitian ini adalah true experimental dengan rancangan post test-only with control group design, terdiri dari 26 perlakuan sediaan tunggal dan kombinasi infus pada konsentrasi meniran 5%, 15, 25%, 35% dan sirih cina 10%, 20%, 30%, 40%. Kontrol yang digunakan yaitu Vankomisin 30µg dan akuades. Parameter yang diukur yaitu diameter zona hambat. Analisis data menggunakan uji One-way ANOVA dan uji post-hoc Duncan dengan α = 0,05. Hasil penelitian didapatkan ada perbedaan bermakna dari masing-masing perlakuan sediaan tunggal dan kombinasi (p < 0,05). Sediaan kombinasi infus meniran dan sirih cina yang menghasilkan efek zona hambat optimum lebih besar daripada sediaan tunggalnya terdapat pada konsentrasi meniran 25% + sirih cina 40%. Simpulan dari penelitian ini adalah sediaan kombinasi memiliki daya hambat optimum lebih besar dibandingkan sediaan tunggalnya. Kata-kata kunci: sediaan tunggal, sediaan kombinasi, Phylanthus niruri, Peperomia pellucida, Staphylococcus aureus, Daya hambat optimum
Aktivitas Antibakteri Infus Kayu Laban (Vitex pubescens Vahl.) terhadap Escherichia coli dan Pseudomonas aeruginosa Salsabella Firqah Najiyah; Edyson Edyson; Husnul Khatimah
Homeostasis Vol 4, No 3 (2021)
Publisher : Homeostasis

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Abstract: Laban (Vitex pubescens Vahl.) is a plant often used as herbal medicine by Dayak community. It has antibacterial properties as it contains active compounds such as flavonoids, alkaloids, phenols, steroids and terpenoids. This study was aimed to assess the antibacterial activity of laban wood infusions against Escherichia coli (E.coli) and Pseudomonas aeruginosa (P.aeruginosa). This study used true experimental methods with posttest-only design with control group design, the concentration of laban wood infusion were 20%, 40%, 60%, 80%, and 100%, with ciprofloxacin and sterile aquadest as positive and negative control. The data were analyzed using One-Way ANOVA and Post-hoc Duncan (α=0,05), with substantial differences (p<0.05) in all treatments. The highest inhibitory zone of laban wood infusion is at concentration of 100% against E.coli (18.67 mm), and P.aeruginosa (17.07 mm). It was concluded that laban wood infusion had antibacterial activity against E.coli and P.aeruginosa. Keywords: Laban wood infusion, Escherichia coli, Pseudomonas aeruginosa, antibacterial. Abstrak: Laban (Vitex pubescens Vahl) adalah contoh tumbuhan yang umumnya dimanfaatkan masyarakat dayak sebagai obat herbal. Laban diketahui mempunyai antibakteri karena mengandung senyawa aktif flavonoid, alkaloid, fenol, steroid, dan terpenoid. Studi ini memiliki tujuan untuk menguji aktivitas antibakteri dari infus kayu laban terhadap Escherichia coli (E.coli) dan Pseudomonas aeruginosa (P.aeruginosa). Studi ini memanfaatkan metode true eksperimental dengan rancangan posttest-only with control group design, perlakuan yang digunakan yakni infus kayu laban konsentrasi 20%, 40%, 60%, 80%, dan 100%, dengan siprofloksasin sebagai kontrol positif dan aquadest steril sebagai kontrol negatif. Analisis data memanfaatkan uji One-Way ANOVA dan Post-hoc Duncan (α=0,05) ditemukan perbedaan yang bermakna (p<0,05) pada seluruh perlakuan. Rerata zona hambat tertinggi dari perlakuan infus kayu laban yaitu pada konsentrasi 100% terhadap E.coli (18,67 mm) dan P.aeruginosa (17,07 mm). Disimpulkan bahwa infus kayu laban mempunyai aktivitas antibakteri bagi E.coli serta P.aeruginosa. Kata-kata kunci:    Infus kayu laban, Escherichia coli, Pseudomonas aeruginosa, antibakteri.
HUBUNGAN TINGKAT PENDIDIKAN DAN PEKERJAAN DENGAN PENGETAHUAN TENTANG PENCEGAHAN COVID-19 DI KECAMATAN BANJARMASIN UTARA TAHUN 2021 Muhammad Ihrammuf Tezar; Farida Heriyani; Lisda Hayatie; Meitria Syahadatina Noor; Edyson Edyson
Homeostasis Vol 5, No 3 (2022)
Publisher : Homeostasis

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One of the big reason of the rise in COVID-19 instances is public noncompliance with health protocol implementation. What needs to be enhanced is public awareness about COVID-19 transmission prevention. The research purposes is to analyze the association between education level and occupation in accordance to COVID-19 prevention in North Banjarmasin sub-district. The research method is analytic observational with a cross-sectional approach. Sampling used a purposive sampling method with the size of 50 people from North Banjarmasin sub-district who met two criterias, namely inclusion and exclusion. According to the data gathered in this study, 45 people (90%) had a high education, while 5 people (10%) had a low education. On the occupation, there were 20 people (40%) working and 30 people (60%) not working. The results showed 39 people (78%) had good knowledge and 11 people (22%) had bad knowledge. Fisher's test  results shows that the correlations between education level and knowledge have a p value of 0.006 (p value < 0.05) with PR = 5.142857. And another results of the Fisher’s test for the correlations between occupation and knowledge have a p value of 0.489 (p value > 0.05). The results shown a significant correlations between education level and knowledge of COVID-19 prevention, and there is no remarkable correlations in occupation with knowledge about COVID-19 prevention
Co-Authors Eko Suhartono Ellsa Anggun Karantika Farida Heriyani Hikmah Ika Darmayanta Khatimah, Husnul Lia Yulia Budiarti Lie Vanny Leono Lisda Hayatie Lutfia Papita Derizky Rahmayanti Meitria Syahadatina Noor Muhammad Ihrammuf Tezar Salsabella Firqah Najiyah Supianur Supianur Thea Shagita