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Faramita Hiola
Jurusan Farmasi Fakultas Olahraga dan Kesehatan, Universitas Negeri Gorontalo, Jl. Jenderal Sudirman No. 06 Kota Gorontalo 96128, Indonesia
Chemistry Medicine & Pharmacology

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Senyawa Antidiabetes Fraksi Aktif Daun Ketapang (Terminalia catappa L.) Hamsidar Hasan; Endah Nurrohwinta Djuwarno; Hasrita Samudi; Widy Susanti Abdulkadir; Faramita Hiola
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.15656

Abstract

Antidiabetic is a compound that has a vital role in treating diabetes mellitus. Diabetes mellitus is a chronic metabolic disorder that is characterized by an increase in blood sugar levels. The use of traditional medicine is relatively cheaper and safer compared to synthetic drugs. One of the plants that is often used in traditional herbal medicine is ketapang (Terminalia catappa L.) because it contains a secondary metabolite compound that acts as an antidiabetic. Thus, this present study aimed to determine the n-hexane, ethyl acetate, and methanol extracts that had antidiabetic efficacy on blood sugar levels and compound group that acts as antidiabetic. The research employed mehods of multiple maceration, phytochemical screening, thin layer chromatography, and antidiabetic test, while the most effective antidiabetic efficacy was then continued to the fractionation stage using vacuum liquid chromatography and gravity column chromatography. Furthermore, the preparative thin layer chromatography (PTLC) analysi, UV-Vis zspectrometry and FTIR were carried out. The research findings revealed that the maximum wavelength of active fraction in ketapang (Terminalia catappa L.) leaves was 410.50 nm, and FTIR spectrum had functional groups of O-H (hydroxyl) C=O (carbonyl Co (aliphatic), C-O (ether) and CH3. Based on the finding, it could be concluded, that antidiabetic compound that plays a role in active fraction of ketapang (Terminalia Cappy L.) leaves was a flavonoid compound.
Isolasi dan Uji Aktivitas Antiinflamasi Ekstrak Daun Andong (Cordyline fructicosa (L) A.Chev) Endah Nurrohwinta Djuwarno; Hamsidar Hasan; Mahdalena Sy. Pakaya; Faramita Hiola; Dewa Ayu Puspita
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15740

Abstract

Andong (Cordyline fructicosa (L) A. Chev) is used as traditional medicine, the use of this traditional medicine is related to the content of secondary metabolites contained in the andong plant. Empirically people use this plant as an antioxidant, the compound that acts as an antoixidant is related to antiinflamasi. The purpose of this study was to isolate secondary metabolites from the extracts of N-Hexane, Ethyl Acetate, and Methanol from Andong (Cordyline fructicosa (L) A. Chev) leaves and to determine the anti-inflamatory effect of the isolated secondary metabolites of Andong (Cordyline fructicosa (L) A. Chev) leaves through in vitro with red blood cell stabilization method. Several methods are used in the isolation of these compounds, namely extraction, identification of compound, fractionation of KCV and KKG, KLT,KLTP, and characterizationof compounds using UV-VIS spectrophotometry and FTIR. The results of UV-VIS characterization show a maximum wavelength of 434 nm, and the results of  FTIR characterization indicate the presence of a functional groups namely O-H (Hidroxyl) at a wave number of 3448,72 cm-1, C-H (Aliphatic) at a wave number of 2954,95 cm-1, 2920,23 cm-1, and 2852,72 cm-1, aliphatic compounds are supported by the presence of CH2 and CH3 at wave number of 1463,97 cm-1 and 1379,10 cm-1, C=O (conjugated carbonyl) at wave number of 1721,79 cm-1, C=C at wave number of 1633,71 cm-1, C-O at wave number of 1294,24 cm-1. So it is very likely that the compounds in Andong leaves isolate are flavonoid compounds. Furthermore, the activity of results of the isolation is tested where the isolate whit a concentration of 100 ppm signifies the highest anti-inflamatory activity, with the ability to stabilize red blood cell membranes of 80,142 %.
Perbedaan Pengetahuan dan Sikap Masyarakat Terhadap Pemberian Booklet dan Video Dagusibu Antibiotik Madania Madania; Nur Rasdianah; Nur Ain Thomas; Faramita Hiola; Sri Nur'ain E. Ahmad
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.15547

Abstract

Inappropriate use of antibiotics is common in the world, both in the community and in the hospital environment, which can lead to antibiotic resistance. The purpose of this study was to determine the knowledge and attitudes of the community before and after being given the booklet and video of dagusibu antibiotics and to determine the differences and influence of community knowledge and attitudes towards the administration of the booklet and video of the dagusibu antibiotic in Lopo Village, Batudaa Pantai Sub-District, Gorontalo Regency. This research applied a quasi-experimental design with the provision of booklets and videos before and after being given education. The number of samples was 74 which were taken using non-probability sampling technique. Research data were analyzed using Wilcoxon test and Man-Whitney test. The results showed that most of the community's knowledge before being given education was still in the sufficient category (57% booklet and 62% video), and the community's attitude was in the negative category (73% booklet and 84% percent video). Meanwhile, after being given education, the community's knowledge had increased to a good category (72% booklet and 86% videos), and community's attitudes had increased to a positive category (93% booklets and videos 98%) as well. Therefore, it can be concluded that there was a significant effect on increasing knowledge and attitude after being given booklets and videos (P0.1), and there was no significant difference between giving booklets and videos on increasing community’s knowledge and attitudes (P0.1).
Co-Authors Dewa Ayu Puspita Endah Nurrohwinta Djuwarno Hamsidar Hasan Hasrita Samudi Madania Madania Mahdalena Sy. Pakaya NUR AIN THOMAS Nur Rasdianah Sri Nur'ain E. Ahmad Widy Susanti Abdulkadir