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Sigit Triyus Priyantoro, Sigit Triyus
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Health Professions Medicine & Pharmacology Public Health

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Peranan Gut Mikrobiota dalam Patogenesis Inflammatory Bowel Disease dan Pendekatan Terapi Probiotik Priyantoro, Sigit Triyus; Mustika, Syifa
Cermin Dunia Kedokteran Vol 42, No 6 (2015): Malaria
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (432.021 KB) | DOI: 10.55175/cdk.v42i6.1003

Abstract

Mikrobiota merupakan sekumpulan mikroorganisme (bakteri, archae, eukaryote dan virus) yang hidup pada host atau tempat khusus host seperti saluran cerna manusia. Terdapat kurang lebih 500-1000 spesies mikrobiota di dalam saluran pencernaan, didominasi oleh bakteri anaerobik. Mikroorganisme atau mikrobiota sangat penting untuk melindungi permukaan mukosa hewan dan manusia terutama saluran cerna. Penyakit yang dikaitkan dengan kondisi dysbiosis mikrobiota saluran cerna antara lain Inflammatory Bowel Disease (IBD), dan penyakit alergi atau atopi. Konsep ini yang mendasari penggunaan probiotik dalam penatalaksanaan penyakit.Microbiota are microorganisms (bacteria, archae, viruses, eukaryote) living in host or special location such as in human gastrointestinal tract. Microbiota microorganism is very important in animal and human to protect mucosal surfaces, especially digestive tract. There are approximately 500-1000 microbiota species in the gastrointestinal tract, dominated by anaerobic bacteria. Various diseases associated with gastrointestinal microbiota dysbiosis conditions are Inflammatory Bowel Disease (IBD) and allergic or atopic disease. This concept underlies the use of probiotics in management of diseases like in inflammatory bowel disease.
Hepatitis Autoimun Priyantoro, Sigit Triyus; Achmad, Harijono
Cermin Dunia Kedokteran Vol 41, No 10 (2014): Hematologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.818 KB) | DOI: 10.55175/cdk.v41i10.1100

Abstract

Laki-laki 22 tahun datang ke rumah sakit karena keluhan lemah badan, dan kadar serum transaminase tetap tinggi AST (757 IU/L) dan ALT (345 IU/L) setelah didiagnosis hepatitis akut, dirawat di RS 3 bulan yang lalu dan mengkonsumsi hepatoprotektor. Hasil pemeriksaan seromarker hepatitis negatif, hipergammaglobulinemia, tes ANA negatif. Hasil biopsi hati menyokong gambaran hepatitis autoimun. Pengobatan dengan metilprednisolon oral 16 mg perhari dan hepatoprotektor menghasilkan penurunan kadar serum transaminase dan perbaikan gejala kelelahan badan.A 22-year-old man was referred to our hospital because of liver dysfunction with increased serum levels of AST/SGOT (757 IU/l) and ALT/ SGPT (345 IU/l). Histological findings after liver biopsy were compatible to autoimmune hepatitis (AIH). He was formerly admitted to other hospital 3 months ago, and diagnosed with acute viral hepatitis, but his serum level transaminase remains elevated. He had negative hepatitis viral marker, hypergammaglobulinemia and liver biopsy compatible to autoimmune hepatitis (AIH). Treatment with methylprednisolone 16 mg once daily and hepatoprotector resulted in decreased serum level transaminase and clinical improvement.
Co-Authors Harijono Achmad Harijono Ahmad Syifa Mustika