<![CDATA[Abstrak           Tanaman iler secara tradisonal digunakan masyarakat Amuntai Kalimantan Selatan untuk penghilang rasa nyeri, demam dan menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk mengetahui aktivitas dan pengaruh paling besar dari ekstrak etanol tanaman iler (Coleus atropurpureus Benth) yang dapat menimbulkan penurunan kadar glukosa darah pada tikus putih jantan. Tikus diinduksi aloksan 150mg/kgBB secara intraperitonial dan dikatakan diabetes jika kadar glukosa darah ⥠150 mg/dL. Tikus dikelompokkan menjadi 6 kelompok yaitu kontrol positif glibenklamid sebanyak 0,45 mg/kgBB, kontrol negatif NaCMC 1 % dan dosis ekstrak etanol tanaman iler yaitu 25mg/kgBB, 50mg/kgBB, 100mg/kgBB dan 200mg/kgBB. Pengukuran kadar glukosa darah dilakukan pada hari ke-0 (setelah tikus diinduksi aloksan dan menjadi diabetes), 4, 7, 10 dan 14. Nilai persen perubahan kadar glukosa darah dianalisis menggunakan uji Kruskal wallis dan uji Mann-Whithney. Hasil analisis menunjukkan bahwa ekstrak etanol tanaman iler dosis 100mg/kgBB dan 200mg/kgBB menunjukkan tidak berbeda nyata dengan kontrol positif glibenklamid. Semua dosis ekstrak etanol iler menujukkan penurunan kadar glukosa darah. Dosis ekstrak 200mg/kgBB memberikan aktivitas terbesar yang dapat menurunkan kadar glukosa darah pada hewan uji. Kata Kunci : Glukosa Darah, Ekstrak Etanol, Iler AbstractTraditionally, Iler plant is used by the people in Amuntai, South Kalimantan for healing the pain, fever and decreasing the level of blood glucose. The aim of this research is to determine activities and the largest effect of ethanol extract of iler plant (Coleus atropurpureus Benth) which can decrease blood glucose on the white male rats. The rats is inducted with alloxan doses 150 mg/kgBB intraperitonial, rat has diabetes if the level of blood glucose ⥠150 mg/dL. The rats are divided into 6 groups, consist of positive control of glibenclamide 0.45 mg/kgBB, negative control NaCMC 1% and ethanol extract of iler plant doses 25 mg/kgBB, 50 mg/kgBB, 100 mg/kgBB, and 200 mg/kgBB. Measurement of blood glucose level was performed on day 0 (after the rats are inducted with alloxan and becoming diabetes), 4, 7, 10 and 14. The percentage of blood glucose level change was analyzed using Kruskal Wallis test, and Mann Whitney test. Analysis result showed that extract ethanol of Iler plant with doses 100 mg/kgBB and 200 mg/kgBB was not significantly different from the positive control glibenclamide. All of doses of ethanol extract of iler referred to the decreasing of level of blood glucose. The doses 200mg/kgBB contributed the largest activity that able to decrease the level of blood glucose of laboratory animal. Key words : Blood Glukose, Ethanol extract, Iler.]]>
