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Ira Widjiastuti
Faculty of Dental Medicine, Universitas Airlangga,Surabaya,Indonesia
Dentistry

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Effective dose of propolis extract against pain response in mice (Mus musculus) using writhing test method Chonny Salsabilla Zamrutizahra; Ira Widjiastuti; Sri Kunarti
Conservative Dentistry Journal Vol. 12 No. 2 (2022): July-December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v12i2.2022.86-89

Abstract

Background: Odontogenic pain has a high prevalence. One of the alternative materials used as medicine in dentistry is propolis. Propolis is a mixture of natural resins containing flavonoid and phenolic acids that play a role in suppressing the pain response through COX and NF-kB inhibition mechanisms. The content of active propolis compounds is influenced by the type of bee, region, geographical conditions, climate change, seasons, and botanical sources causing different effectiveness of propolis. This is supported by several studies that show a variety of effective doses that produce an optimal analgesic effect, thus a research plan was developed to discover the effective dose of propolis extract on suppressing pain response in mice using the writhing test method. Purpose: To determine the effective dose of propolis extract towards pain response in mice. Methods: This study was conducted using the writhing test method to see the analgesic effect of propolis extract. The research sample consisted of 30 mice which were divided into five treatment groups, namely the piroxicam control group, and the propolis extract group at doses of 35 mg/kgBW, 70 mg/kgBW, 105 mg/kgBW, 140 mg/kgBW. Results: The results showed that the propolis extract dose of 70 mg/kgBW had no significant difference with the piroxicam control group, while between the doses of 35 mg/kgBW, 105 mg/kgBW, 140 mg/kgBW there was a significant difference towards the piroxicam control group. Conclusion: Propolis extract 70 mg/kgBW is the effective dose in suppressing pain response in mice
Management of Enamel Hypoplasia in Maxillary Incisors with Composite Direct Veneers: Case Report Ayu Rafania Atikah; Edward Irwantoro; Ira Widjiastuti
Conservative Dentistry Journal Vol. 12 No. 2 (2022): July-December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v12i2.2022.100-104

Abstract

Background: Dental esthetics is an important aspect that needs to be considered in today’s dental treatment planning. Enamel hypoplasia is teeth discoloration from yellowish to brownish due to disturbances during the amelogenesis process. Direct veneers are a conservative treatment option that supports the esthetics of anterior teeth. Purpose: To improve patient’s appearance by a viable treatment option that offered rehabilitation of anterior teeth. Case: A 18-year-old female patient felt uncomfortable and wanted to improve her appearance because the front teeth had old fillings turned yellowish and white spots. Objective examination showed enamel hypoplasia in 12, 11, 21, 22 and secondary caries in 11 and 22. Case Management: The treatment plan was direct composite veneers. The initial stage is digital smile design analysis and composite shade selection using the button try technique. Minimally invasive preparations were performed on teeth 12, 11, 21, 22. Etching using 37% phosphoric acid and bonding agent was applied to the prepared enamel. The layering technique is used for composite applications. Finishing, contouring and polishing using Soflex Disc Coarse and Diacomp Twist. Conclusion: Direct composite veneers are a viable treatment option for patients requiring rehabilitation of anterior teeth.
Effective Dose of Nano Propolis as Anti-Pain in Animal Models of Mus Musculus Using Writhing Test Method Annisa Salsabila Witjaksana; Ira Widjiastuti; Devi Eka Juniarti
Conservative Dentistry Journal Vol. 13 No. 1 (2023): January-June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v13i1.2023.7-10

Abstract

Background: Odontogenic pain has a high prevalence where this pain is the result of noxious physical stimuli or calming inflammatory mediators that stimulate receptors located at the terminal ends of nociceptive C and Aδ afferent nerve fibers. Nano propolis is an alternative material that is used as a medicine in dentistry. Nano propolis is a mixture of natural resins containing flavonoids and phenolic acids which play a role in suppressing pain response through COX and NF-kB inhibition mechanisms. Nanoparticle technology is capable of preparing active drug ingredients in nano-sized particles and can affect drug effectiveness, because particle size affects the process of solubility, absorption and distribution of drugs. Research on the potential of nano propolis as an anti-pain is still minimal, so further research is needed on the function of nano propolis as an alternative anti-pain agent. Purpose: To determine the effective dose of nano propolis on pain response in Mus musculus. Methods: This research was conducted using the writhing test method to see the analgesic effect of nano propolis. The research sample consisted of 28 Mus musculus which were divided into four treatment groups, namely the piroxicam control group, and the nano propolis treatment group of 17.5 mg/kg, 35 mg/kg, and 70 mg/kg. Results: The results showed that the four treatment groups did not have a significant difference, in other words, they had the same anti-pain effect. Conclusion: Nano propolis 35 mg/kgBB is an effective dose in suppressing pain response in Mus musculus.
The potency of propolis extract as anti-inflammatory agent for stimulation of reparative dentin formation Cinitra Anindya; Ira Widjiastuti; Nanik Zubaidah
Conservative Dentistry Journal Vol. 13 No. 1 (2023): January-June
Publisher : Universitas Airlangga

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Abstract

Background: As an effort to treat a deep caries lesion with a diagnosis of reversible pulpitis, one of the treatment options is pulp capping. For decades, calcium hydroxide has been considered the most acceptable pulp capping material and has been routinely used in dental practice, but it also has some weakness. To overcome that, alternative materials are needed that can provide a better effect. Recently, a lot of research has been done using natural ingredients, including Propolis. Propolis has been known to have strong antimicrobial and anti inflammatory properties. Therefore, it is necessary to conduct a deeper study regarding the potency of propolis extract as an anti inflammatory agent for the stimulation of reparative dentin formation so that it can be considered to be used as a pulp capping material. Objective: The aim of this literature review is to highlight the potency of propolis extract as anti inflammatory agent in the natural stimulation of reparative dentin formation. Methods: The search strategy consist of an electronic research using databases such as PubMed, Google Scholar, Science Direct, dan Springer Link for studies published from 2003 to 2021 regarding the potency of propolis extract as anti inflammatory agent for stimulation of reparative dentin formation, including review articles and research articles. Results: Propolis and its constituents have been proven to be used as a potent natural anti inflammatory, it also considered to have the ability to promote reparative dentin formation. However, there are some literatures stated that reparative dentin does not form with the application of propolis, and the causes may vary. Conclusion: Propolis extract has a potency as an anti inflammatory agent in dental pulp inflammation by inhibiting TNFα expression, and increasing TGF-β1 expression, as well as its potency in stimulating the formation of reparative dentin. Based on this review, further studies are needed.
Co-Authors Annisa Salsabila Witjaksana Ayu Rafania Atikah Chonny Salsabilla Zamrutizahra Cinitra Anindya Devi Eka Juniarti Edward Irwantoro Nanik Zubaidah Sri Kunarti