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All Journal JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Indonesian Journal of Pharmacology and Therapy
Juniarto Mende
Magister Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Drug-related problems (DRPs) on antibiotic therapy in pediatric patients: a review Arina Titami; Juniarto Mende; Nurfina Dian K.
Indonesian Journal of Pharmacology and Therapy Vol 3 No 2 (2022)
Publisher : Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFI) and Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.773 KB) | DOI: 10.22146/ijpther.2692

Abstract

Drug-related problems (DRPs) is event that can interfere with the outcome of therapy. It can occur in various patient populations and ages. The DRPs in pediatric patients is found to be significantly frequent due to their vulnerable features. Many factors such as age, weight, body surface area should be considered during drug therapy in pediatric patients. The organs development continues for many years and the organs responsible for drug metabolism and elimination have not yet full capacity in pediatric patients. Antibiotics are often prescribed to pediatric patients. Several studies concerning DRPs on antibiotic therapy have been conducted in some countries. This review summarizes types, factors and impacts to the occurrence of DRPs on antibiotic therapy in pediatric patients.
Keamanan Penggunaan Antiglukolan pada Pasien Rawat Inap Stroke Iskemik dengan Atrial Fibrilasi Juniarto Mende; Fita Rahmawati; Ika Puspitasari
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 12, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.74893

Abstract

Atrial fibrillation can cause stroke due to blood stasis in left atrium which triggers thrombus formation and embolization to the brain. Administration of anticoagulants is used to prevent clot formation so as to prevent the occurrence of stroke, but on the other hand it is associated with the risk of bleeding side effects. This study aims to evaluate the safety of anticoagulants in ischemic stroke patients with atrial fibrillation. The study used a cross sectional design. Retrospective data were taken from the medical records of RSUP Dr. Sardjito, Yogyakarta period January 2018 to December 2020. The research subjects were ischemic stroke patients with atrial fibrillation. Evaluation of the safety of anticoagulants includes the number of major and minor bleeding events in each type of anticoagulant and the factors that influence the occurrence of bleeding. A total of 70 patients met the study inclusion criteria. Bleeding occurred in 41 cases (58,57%). Major bleeding was 28 patients (40%) and minor bleeding was 13 patients (18,57%). The most common anticoagulant that causes bleeding is warfarin. Multivariate test of the factors that influence the occurrence of bleeding in kidney failure (OR = 5,990; 95% Cl 2,002-17,920; p = 0,001). Monitoring the side effects of anticoagulants, especially warfarin is necessary. Pharmacists can play an important role in monitoring and preventing bleeding events by taking into account risk factors, especially kidney failure.
Co-Authors Arina Titami Fita Rahmawati Ika Puspitasari Nurfina Dian K.