Article Per Year (5 Year)
p-Index From 2019 - 2024
0.23
P-Index
This Author published in this journals
All Journal Sasambo Journal of Pharmacy
Iman Akhyar Firdausy
IPB University
Health Professions Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Molecular docking study of natural compounds from red betel (Piper crocatum Ruiz & Pav) as inhibitor of secreted aspartic proteinase 5 (Sap 5) in Candida albicans Gusnia Meilin Gholam; Iman Akhyar Firdausy
Sasambo Journal of Pharmacy Vol. 3 No. 2 (2022): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i2.145

Abstract

Candida albicans can cause adverse infections in humans. The targeting of Sap 5 is due to its virulence factor in C. albicans. The method used is molecular docking using YASARA structure and BIOVIA Discovery Studio. The purpose of this study was to investigate the molecular interaction between red betel and Sap 5 as a potential inhibitor of C. albicans in infecting humans. The results showed that CHEMBL216163 (9,644 kcal/mol) and MLS000557666 (9,525 kcal/mol) have Binding energy above Pepstatin (9,484 kcal/mol) and affect the active site of Sap 5 so that the two test ligands could be further analyzed.
Co-Authors Gusnia Meilin Gholam