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All Journal Sasambo Journal of Pharmacy Jurnal Sains dan Kesehatan Jurnal Teknologi Lingkungan Lahan Basah
Gusnia Meilin Gholam
IPB University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Energy Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Molecular docking of the bioactive compound Ocimum sanctum as an inhibitor of Sap 1 Candida albicans Gusnia Meilin Gholam
Sasambo Journal of Pharmacy Vol. 3 No. 1 (2022): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i1.157

Abstract

Candida albicans (C. albicans) is the norm microbiota that lives in humans' oral cavity, digestive tract, and urinary tract. However, C. albicans, under certain circumstances can cause superficial infections of the mucosa such as oropharyngeal candidiasis (OPC) or vulvovaginal candidiasis (VVC) and even systemic infections. Secreted aspartic proteinase (Sap) 1 plays a role in the phenotype change of C. albicans. The study aimed to perform molecular docking using the bioactive compound Ocimum sanctum to inhibit Sap 1 C. albicans. Methods used include preparation of protein structures, ligands preparation, simulation of docking, and analysis and visualization. The results showed Apigenin had the highest binding energy of 7,792 kcal/mol and was followed by methyl eugenol ligand 5,361 kcal/mol, Citral 5,307 kcal/mol, Ursolic acid 4,967 kcal/mol, and Taxol 2,118 kcal/mol. Known interactions from the docking results showed that the four ligands hit the catalytic residue Asp32/Asp218, but only ursolic acid did not hit the catalytic residue. This study concludes that all ligands have binding energies that inhibit Sap 1, resulting in various interactions, amino acid residue contacts, and dissociation constants.
Pembuatan dan Edukasi Pentingnya Lubang Resapan Biopori (LRB) untuk Membantu Meningkatkan Kesadaran Mengenai Sampah Organik serta Ketersediaan Air Tanah di Dusun Tumang Sari Cepogo Gusnia Meilin Gholam; Intan Dwi Kurniawati; Putri Nur Laely; Rizky Amalia; Nur Adha Mutiaradita; Seno Nur Rohman; Sifana Pangestiningsih; Hesti Widyaningsih; Khoirotul Rizki Amalia
Jurnal Teknologi Lingkungan Lahan Basah Vol 9, No 2 (2021): Juli 2021
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (708.975 KB) | DOI: 10.26418/jtllb.v9i2.48548

Abstract

Generally, Tumang Sari, Cepogo is dry land in the form of yards, fields, and plantations. Low environmental awareness in Tumang Sari regarding rainwater infiltration and organic waste management results in environmental problems such as waterlogging, garbage accumulation and health problems. Biopore Infiltration Hole (LRB) is expected to be a solution to these environmental problems. This program aims to increase public understanding of how to optimize rainwater catchment areas and overcome the problem of organic waste. The methods used are socialization and delivery of materials, training and assistance in making LRB, as well as post-activity monitoring and evaluation. The results obtained are  improvement knowledge, understanding and skills of the Tumang Sari community after the socialization and assistance by the KKN-T Team. The LRB socialization and development program which was carried out in Tumang Sari received good support and response from the government and the local community. Socialization activities and the practice of making LRB is hoped can reduced  the volume of puddles and the organic waste in the LRB begun to decomposed and became to be compost.
Aktivitas Antiulseratif Berbagai Tanaman Herbal dan Prospek Masa Depan Sebagai Tanaman Budidaya : Anti-ulceritis Activity of Various Herbal Plants and Future Prospects as Cultivated Plants Hafizh Zahra; Rosa Berlina Haridas; Gusnia Meilin Gholam; Aprijal Ghiyas Setiawan
Jurnal Sains dan Kesehatan (J. Sains Kes.) Vol. 4 No. 3 (2022): Jurnal Sains dan Kesehatan (J. Sains Kes.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (351.367 KB) | DOI: 10.25026/jsk.v4i3.1046

Abstract

Peptic ulcer disease (PUD) is one of the most common gastrointestinal disorders in individuals aged 20-50 with 1081 cases of death (0.08%) in Indonesia. The main risk factors for PUD include the use of non-steroidal anti-inflammatory drugs, Helicobacter pylori infection, alcohol, smoking, and physical stress. Nowadays, PUD treatment has transformed using secondary metabolites of herbal plants to compete with allopathic treatment adverse effects. Through this systemic review, several herbal plant metabolites from various studies are responsible for gastroprotective, inhibition of certain neurotransmitters, proton pump repression, or different anti-inflammatory effects. The literature search was carried through extensive databases (PubMed, Science Direct, Semantic Scholar, Springer Link, SAGE, and Google Scholar) with keywords linked with PUD. The scope of the data investigated included plant species, groups of metabolites, in vivo application doses, metabolites mechanism of action, and analytical methods.
Molecular docking study of natural compounds from red betel (Piper crocatum Ruiz & Pav) as inhibitor of secreted aspartic proteinase 5 (Sap 5) in Candida albicans Gusnia Meilin Gholam; Iman Akhyar Firdausy
Sasambo Journal of Pharmacy Vol. 3 No. 2 (2022): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i2.145

Abstract

Candida albicans can cause adverse infections in humans. The targeting of Sap 5 is due to its virulence factor in C. albicans. The method used is molecular docking using YASARA structure and BIOVIA Discovery Studio. The purpose of this study was to investigate the molecular interaction between red betel and Sap 5 as a potential inhibitor of C. albicans in infecting humans. The results showed that CHEMBL216163 (9,644 kcal/mol) and MLS000557666 (9,525 kcal/mol) have Binding energy above Pepstatin (9,484 kcal/mol) and affect the active site of Sap 5 so that the two test ligands could be further analyzed.
Co-Authors Aprijal Ghiyas Setiawan Hafizh Zahra Hesti Widyaningsih Iman Akhyar Firdausy Intan Dwi Kurniawati Khoirotul Rizki Amalia Nur Adha Mutiaradita Putri Nur Laely Rizky Amalia Rosa Berlina Haridas Seno Nur Rohman Sifana Pangestiningsih