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All Journal As-syifaa Jurnal Farmasi
Ayyub Harly Nurung
Fakultas Farmasi Universitas Muslim Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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PENGARUH INFUSA REBUSAN DAUN KELOR (Moringa oleifera) TERHADAP PENURUNAN KADAR ASAM URAT DALAM DARAH PADA HEWAN COBA MENCIT JANTAN (Mus musculus) Izal Zahran; Ayyub Harly Nurung; Abd Razak; Rusli Rusli
As-Syifaa Jurnal Farmasi Vol 14, No 2 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i2.863

Abstract

Gout is the result of metabolism in the body whose levels should not be excessive, everyone has uric acid in their body, because every normal metabolism will produce uric acid while the trigger is food factors and other compounds that contain lots of purines. The purpose of this study was to determine the effect of giving Moringa oleifera leaf infusion on blood uric acid levels in mice using 25 mice which were divided into 5 groups, namely the positive control group, the infusion 20%, and the infusion 40%, infusion 60% and negative control with treatment for 3 weeks. Measurement of uric acid levels using an autocheck tool. The results of the measurement of uric acid levels in the infusion group 20% showed an average decrease of 0.16 mg/dl, in the 40% group the infusion showed an average value of 0.62 mg/dl and in the infusion group 60% showed an average value of 0.92 mg/dl. The higher the concentration of Moringa oleifera infusion, the lower the uric acid level
AKTIVITAS ANTIBAKTERI FERMENTAT FUNGI ENDOFIT DAUN KASUMBA TURATE (Carthamus tinctorius L.) ASAL GALESONG TERHADAP BAKTERI UJI PENYEBAB INFEKSI KULIT Rusli Rusli; Rachmat Kosman; Muthmainnah Muthmainnah; Ayyub Harly Nurung
As-Syifaa Jurnal Farmasi Vol 15, No 1 (2023): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v15i1.905

Abstract

Kasumba turate (Carthamus tinctorius L.) contains phenolic compounds of flavonoids and carotenoids which have antioxidant, antibacterial, antiviral, anti-inflammatory, antiallergic and anticancer activities. This study aims to obtain isolates of endophytic fungi that have potential as antibacterial using the TLC-Bioautography method. This research was conducted by isolating endophytic fungi from the leaves of kasumba turate (Carthamus tinctorius L.) and after that purification and macroscopic tests were carried out and eight pure isolates were obtained. The results of the isolate screening tests with IFDKT 5 and IFDKT 6 codes showed the highest inhibition. Then tested the antibacterial activity by TLC-Bioautography. The isolates with IFDKT code 5 showed five spots were active against Staphylococcus aureus and Pseudomonas aeruginosa (Rf1 0.83; Rf2 0.65; Rf3 0.47; Rf4 0.30; Rf5 0.07), and six spots were active against bacteria Staphylococcus epidermidis (Rf1 0.94; Rf2 0.83; Rf3 0.65; Rf4 0.47; Rf5 0.30, Rf6 0.07). Then, the isolates with code IFDKT 6 showed four active spots against Staphylococcus aureus and Pseudomonas aeruginosa (Rf1 0.80; Rf2 0.58; Rf3 0.40; Rf4 0.10), and five spots were active against Staphylococcus epidermidis (Rf1 0.96; Rf2 0.80; Rf3 0.58; Rf4 0 .40; Rf5 0.10). Therefore, fermentate isolate of the endophytic fungus of kasumba turate leaves (Carthamus tinctorius L.) has the potential to inhibit Staphylococcus aureus, Stahpyloccous epidermidis and Pseudomonas aeruginosa bacteria that cause skin infections
Co-Authors Abd Razak Izal Zahran Muthmainnah Muthmainnah Rachmat Kosman Rusli Rusli Rusli Rusli