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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Syiah Kuala Sari Pediatri Caring : Jurnal Pengabdian Masyarakat Pediatric Sciences Journal IJRETINA - International Journal of Retina
Susanto Nugroho
Departments Of Pediatrics, Dr. Saiful Anwar General Hospital, Faculty Of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia, 65111
Agriculture, Biological Sciences & Forestry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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Microbiologically documented infection and antimicrobial sensitivities in pediatric malignancy patients with febrile neutropenia at Dr Saiful Anwar Hospital, Malang, Indonesia Savitri Laksmi Winaputri; Dominicus Husada; Budi Utomo; Irene Ratridewi; Susanto Nugroho; I Dewa Gede Ugrasena; Parwati Setiono Basuki; Ismoedijanto Ismoedijanto
Jurnal Kedokteran Syiah Kuala Vol 21, No 1 (2021): Volume 21 Nomor 1 April 2021
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v21i1.20903

Abstract

Abstract. Background: Febrile neutropenia in malignancy children increase the risk of infection, morbidity and mortality. Microbiologically documented infection in pediatric malignancy has not been studied in Saiful Anwar Hospital. Purpose: Determine profile of blood, urine, sputum, and wound bed culture and antimicrobial sensitivities pattern in pediatric malignancy patients with febrile neutropenia. Methods: Pediatric malignancy patients with febrile neutropenia and microbiologically documented infection admitted to dr Saiful Anwar General Hospital Malang, were studied from 2016 to 2019.  Bacterial and fungal etiology were identified, along with antimicrobial sensitivities patterns. Results: 53 (17%) of 307 pediatric malignancy patients with febrile neutropenia experienced 75 episodes of microbiologically documented infection. 40 (53,3%) gram-negative and 34 (45,3%) gram-positive isolated from 75 isolated pathogens. The most common gram-negative were Klebsiella pneumonia (n=15) and Escherichia coli (n=8). The most common gram-positive were Coagulase-negative Staphylococci (n=14) and Enterococcus faecalis (n=7). Escherichia coli, Coagulase-negative Staphylococci, Enterococcus faecalis, and Staphylococcus aureus were 100% sensitive to all tested antimicrobials. Klebsiella pneumonia and Acinetobacter baumanni were 100% sensitive to almost all tested antimicrobials. Pseudomonas aeruginosa was found less sensitive (0-80%) to all tested antimicrobials. Conclusion: Investigation of antimicrobial sensitivities of these organisms may guide successful antimicrobial therapy and improve quality of pediatric malignancy care. Abstrak. Latar Belakang: Demam neutropenia pada keganasan anak meningkatkan risiko infeksi, morbiditas dan mortalitas. Microbiologically Documented Infection merupakan masalah utama di dunia, namun belum dilakukan penelitian di RSUD Dr. Saiful Anwar. Tujuan: Melihat gambaran kultur darah, urine, sputum, dan dasar luka dan pola sensitivitas antimikroba pada keganasan anak dengan demam neutropenia. Metode: Pasien keganasan anak dengan demam neutropenia di bangsal Hemato-onkologi Departemen Ilmu Kesehatan Anak RSUD Dr. Saiful Anwar Malang dan terdiagnosis Microbiologically Documented Infection pada tahun 2016-2019, ditentukan etiologi, serta pola sensitivitas antimikroba. Hasil: Dari 307 pasien keganasan anak dengan demam neutropenia, 53(17%) pasien mengalami 75 episode microbiologically documented infection. Didapatkan 40(53,3%) bakteri gram negatif dan 34(45,3%) gram positif dari 75 hasil kultur. Bakteri gram negatif yang paling banyak ditemukan adalah Klebsiella pneumonia (n=15) dan Escherichia coli (n=8), serta Coagulase-negative Staphylococci (n=14) dan Enterococcus faecalis (n=7) pada gram positif. Escherichia coli, Coagulase-negative Staphylococci, Enterococcus faecalis, dan Staphylococcus aureus 100% sensitif terhadap semua antimikroba yang diuji. Klebsiella pneumonia dan Acinetobacter baumanni 100% sensitif terhadap hampir semua anitmikroba yang diuji. Pseudomonas aeruginosa memiliki sensitivitas rendah (0-80%) terhadap semua antimikroba yang diuji. Kesimpulan: Penelitian tentang sensitivitas antimikroba pada organisme tersebut dapat menjadi panduan untuk keberhasilan terapi dan meningkatkan kualitas pelayanan pada keganasan anak.
Peran Skor Kandida Sebagai Metode Diagnostik Kandidiasis Invasif Terhadap Neutropenia Berat pada Anak dengan Keganasan Irene Ratridewi; Nanda Juwita; Marvin Anthony Putera; Susanto Nugroho
Sari Pediatri Vol 22, No 6 (2021)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp22.6.2021.351-8

Abstract

Latar belakang. Infeksi kandidiasis invasif meliputi infeksi aliran darah dan infeksi invasif dalam lainnya yang disebabkan oleh spesies Kandida dan merupakan penyebab morbiditas dan mortalitas yang signifikan, khususnya pada pasien dengan status immunocompromised, seperti pada kondisi keganasan hematologis, kelainan limfoproliferatif, dan gangguan myeloproliferative.Tujuan. Menginvestigasi peran skor Kandida, dibandingkan dengan kultur darah dan PCR, sebagai alat diagnostik kandidiasis invasif pada pasien dengan neutropenia berat, khususnya pada kasus keganasan.Metode. Penelitian ini menggunakan desain penelitian cross sectional. Data yang diperoleh diolah dan dianalisis menggunakan metode Receiver operating characteristic (ROC) untuk mendapatkan nilai area under curve (AUC). Berdasarkan kurva AUC kemudian dilakukan pencarian titik potong yang paling optimal untuk mendapatkan nilai sensitivitas dan spesifisitasHasil. Hasil penelitian menunjukkan bahwa pada kedua kelompok dengan kultur positif dan negatif tidak didapatkan perbedaan bermakna berdasarkan karakteristik jenis kelamin, usia, berat badan, status gizi, dan diagnosis klinis (uji Mann-Whitney, p>0,05).Kesimpulan. Berdasarkan hasil tersebut, dapat disimpulkan bahwa tidak didapatkan perbedaan pada sensitivitas dan spesifisitas skor Kandida dibandingkan dengan hasil kultur pada pada pasien anak dengan neutropenia berat.
Correlation of cell apoptosis index and hematology profile in children with acute myeloblastic leukemia with chemotherapy induction Arief Rahman; Susanto Nugroho; Sony Wicaksono
Pediatric Sciences Journal Vol. 3 No. 1 (2022): (Available online 1 June 2022)
Publisher : Medical Faculty of Brawijaya University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/pedscij.v3i1.32

Abstract

Background: Acute myeloblastic leukemia (AML) is one of the most prevalent pediatric neoplasms, with a poor prognosis and high risk of relapse. Response to induction of chemotherapy and complication occurrence are crucial in the AML patient's outcome. Chemotherapy can induce apoptosis in a cancer cell and the blood cell as a side effect that can cause severe complications. This study aims to evaluate the cell apoptosis index and its correlation with hematologic profile (hemoglobin, leucocyte, thrombocyte, absolute neutrophile count/ANC) between induction chemotherapy administration. Methods: Observational study was performed on children with AML who will undergo induction chemotherapy. The cell apoptosis index and the hematologic profile were evaluated before and after induction chemotherapy. The data was then analyzed to compare the cell apoptosis index and its correlation with the hematologic profile. Result: The mean age of the subjects was 13.6 years old, similar to previous epidemiologic studies, which showed the main incidence at 15 years old. There was a significant increase in cell apoptosis index (p=0.014) and a significant decrease in hemoglobin level (p=0.031) and ANC (p=0.05). The cell apoptosis index had a significantly strong negative correlation with all hematologic profiles. Conclusion: Cell apoptosis index increased after induction chemotherapy in pediatric AML and correlated with the hematologic profile.
Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart Disease Rachmania Putri; Renny Suwarniaty; Loeki Enggar Fitri; Susanto Nugroho; Mohammad Saifur Rahman
Journal of Tropical Life Science Vol. 7 No. 2 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.02.04

Abstract

Rheumatic heart disease (RHD) is mediated by an abnormal immunological response following a Streptococcus pyogenes infection that induces a disturbance of oxidants and antioxidants balances. Mannose-binding lectin (MBL) binds to N-acetylglucosamine, a molecule present on the Streptococcus cell wall and human heart valves. There is a disturbance of oxidant and antioxidant balance in rheumatic disease. Myeloperoxidase (MPO) is a marker of oxidative stress and inflammation. This study was aimed to determine the correlation of MBL and MPO levels and severity of valvular regurgitation and heart failure (HF) in RHD patients. A case-control study was conduct using human peripheral blood samples from 32 children aged 6 to 14 years old. The subjects were divided into two groups: 16 RHD patients included in the case group and 16 healthy children as a control group. The level of MBL and MPO was investigated using ELISA method. There were significant differences on MBL and MPO level between patient and control group. The level of MBL and MPO were significantly increased in RHD group, especially on severe valvular regurgitation. There was a strong correlation between MBL and MPO levels and the severity of valvular regurgitation (r = 0.94 and r = 0.88). The least significant diff-erence (LSD) analysis showed that significant difference occurs in the severe heart failure group. Our research revealed that the MBL and MPO levels in pediatric RHD patients were significantly higher than in healthy children. The MBL and MPO levels were significantly correlated with the severity of valvular regurgitation and heart failure.
EARLY DETECTION OF DEPRESSION IN CHILDREN AND ADOLESCENTS WITH CHRONIC DISEASE DURING THE COVID-19 PANDEMIC Desy Wulandari; Wisnu Barlianto; Susanto Nugroho; Sony Wicaksono; Hajeng Wulandari
Caring : Jurnal Pengabdian Masyarakat Vol 3, No 1 (2023): CARING Jurnal Pengabdian Masyarakat (April 2023)
Publisher : Caring : Jurnal Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.caringjpm.2023.003.01.3

Abstract

Mental health in children and adolescents with chronic illnesses is still a problem that is rarely a concern in Indonesia. There are still many incidents of children and adolescents with depression due to the length of treatment they are undergoing, disease activity, psychological conditions, and support from the environment and family. Therefore, the detection of depressive disorders in children and adolescents still needs to be improved. The Covid-19 pandemic has made parents of patients afraid and anxious to bring their children to health facilities, so monitoring of mental health has been neglected, especially in pediatric and adolescent patients with chronic illnesses. This community service activity is aimed at providing counseling regarding the signs and symptoms of depression detection. Evaluation was carried out by filling out a questionnaire using the Children Depression Inventory (CDI). The conclusion from this activity is that 20% of children and adolescents with chronic illnesses experience mild depression, so further evaluation and intervention is needed.
REMARKABLE RESULT TOWARDS RETINOPATHY ASSOCIATED AUTOIMMUNE HEMOLYTIC ANEMIA Rofa Husnul Khuluqi; Nadia Artha Dewi; Susanto Nugroho; Lely Retno Wulandari
International Journal of Retina Vol 5 No 1 (2022): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2022.vol005.iss001.190

Abstract

Introduction: To present the clinical findings of Autoimmune hemolytic anemia (AIHA) Retinopathy and its rapid resolutions following treatment with steroid. Case report: A 14-year-old female patient presented with decreased vision in the left eye. There was history of AIHA. Visual acuity was 1/60 in LE and 6/6 in RE. There was conjunctival pallor, and the other anterior segment were unremarkable. Fundus examination of left eye revealed flame shaped and dot blot hemorrhage, roth’s spots, optic disc swelling, venous turtuosity, and elevated macula. There were afferent pupil defect, red green deficiency, and contrast sensitivity decline. Hematological evaluation revealed anemia. A MRI Head and Orbital examination were unremarkable. Discussion: This patient was assessed with LE Anemic retinopathy due to AIHA. The patient’s visual acuity improved as the retinopathy resolved after 1 month of oral steroid therapy. Conclusion: Anemia may play a role in the occurrence of retinopathy. The diagnosis of retinopathy can be made by linking ophthalmic fndings with positive serological test. Accurate comprehensive examination can establish the systemic diagnosis, and control of systemic parameters will improve retinopathy, reverse vision loss, and avoid permanent blindness
Co-Authors Arief Rahman Budi Utomo Desy Wulandari Dominicus Husada Hajeng Wulandari I Dewa Gede Ugrasena Irene Ratridewi Ismoedijanto Lely Retno W Loeki Enggar Fitri Marvin Anthony Putera Mohammad Saifur Rahman Nadia Artha Dewi Nanda Juwita Parwati Setiono Basuki Rachmania Putri Renny Suwarniaty Rofa Husnul Khuluqi Savitri Laksmi Winaputri Sony Wicaksono Sony Wicaksono Wisnu Barlianto