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Erladys Rumondor
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UJI AKTIVITAS ANTIOKSIDAN EKSTRAK DAN FRAKSI DARI SPONS (MYCALE VANSOESTI) YANG DIPEROLEH DARI PULAU MANADO TUA Ira Handayani Puspita Prins; Adithya Yudistira; Erladys Rumondor
PHARMACON Vol. 11 No. 3 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

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Antioksidan merupakan senyawa yang berperan dalam mencegah dampak negatif radikal bebas yang dapat menyebabkan berbagai penyakit. Salah satu biota laut yang berpotensi memiliki senyawa bioaktif seperti antioksidan adalah Spons Mycale vansoesti. Tujuan penelitian ini adalah untuk mengetahui aktivitas antioksidan ekstrak dan fraksi dari spons Mycale vansoesti yang diperoleh dari Pulau Manado Tua. Pengujian aktivitas antioksidan dilakukan dengan menggunakan spektrofotometri Uv-Vis pada panjang gelombang 517 nm dengan metode penghambatan radikal bebas DPPH (1,1-difenil-2-pikrilhidrazil) terhadap ekstrak dan fraksi pada konsentrasi 100 ppm. Hasil penelitian menunjukkan bahwa ekstrak etanol, fraksi n-heksana, fraksi kloroform, dan fraksi metanol memiliki aktivitas antioksidan dengan persen inhibisi yang masing-masing diperoleh adalah 62.31 %, 62.40 %, 49.42 %, dan 56.51 %. Kesimpulan yang didapat yaitu ekstrak dan fraksi spons Mycale vansoesti terbukti memiliki aktivitas antioksidan dengan persen inhibisi tertinggi terdapat pada fraksi n-heksana sebesar 62.40 % dengan konsentrasi 100 ppm. 
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK DAN FRAKSI DARI Callyspongia aerizusa YANG DIPEROLEH DARI PULAU MANADO TUA Melisa Oktafiani Makalunsenge; Adithya Yudistira; Erladys Rumondor
PHARMACON Vol. 11 No. 4 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

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Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan pada ekstrak dan fraksi Callyspongia aerizusa yang diperoleh dari pulau Manado Tua. Sampel Callyspongia aerizusa diekstraksi dengan etanol sebagai pelarut dan difraksinasi dengan menggunakan tiga pelarut yaitu methanol, n-heksan, dan kloroform. Pengujian aktivitas antioksidan dilakukan dengan menggunakan metode DPPH (1,1-Diphenyl-2-picrylhydrazil) dan diukur menggunakan alat Spektrofotometri UV-Vis pada panjang gelombang 517 nm. Hasil pengujian aktivitas antioksidan ekstrak dan fraksi Callyspongia aerizusa memiliki aktivitas antioksidan pada konsentrasi ekstrak etanol 100 ppm dengan nilai rata-rata 64,8%, konsentrasi fraksi n-heksan 100 ppm dengan nilai rata-rata 66,8%, konsentrasi kloroform 100 ppm dengan nilai rata-rata 60,4%, dan konsentrasi fraksi methanol 100 ppm dengan nilai rata-rata 67,3%. Kadar antioksidan tertinggi terdapat pada fraksi methanol yaitu mencapai 67,3%.
THE POTENCY OF Mycale vansoesti SPONGE EXTRACT AND FRACTIONS FROM MANADO TUA ISLAND WATERS AGAINST THE GROWTH OF Staphylococcus aureus AND Escherichia coli Komang Ayu May Widyani; Defny Wewengkang; Erladys Rumondor
PHARMACON Vol. 11 No. 3 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

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Sponges are one of the coral reefs components that have the potential to produce secondary metabolites with antibacterial, antifungal, and anticancer properties that have not been widely used. This study aims to determine the antibacterial activity of the extract and fractions of Mycale vansoesti sponge obtained from Manado Tua Island waters against the growth of Staphylococcus aureus as Gram-positive representatives and Escherichia coli bacteria as Gram-negative representatives. Samples were extracted using the maceration method with 95% ethanol solvent and fractionated with the liquid-liquid method using 3 types of solvents with different polarities, namely n-hexane, chloroform, and methanol. Antibacterial activity test using the Kirby-Bauer disc diffusion method. The test results showed that ethanol extract, n-hexane fraction, chloroform fraction and methanol fraction from Mycale vansoesti sponge sample obtained from Manado Tua Island waters have antibacterial activity against Staphylococcus aureus and Escherichia coli with moderate bacterial inhibitory power.
POTENSI EKSTRAK DAN FRAKSI SPONS Liosina paradoxa YANG DIKOLEKSI DARI PERAIRAN PULAU MANADO TUA TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus DAN Escherichia coli. Brian G. A. Adilan; Defny Wewengkang; Erladys Rumondor
PHARMACON Vol. 11 No. 4 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

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Spons atau porifera bisa untuk digunakan sebagai uji antibakteri dikarenakan spons memiliki senyawa metabolit yang ada didalamnya serta dapat menghambat bakteri pathogen yang datang. Tujuan dari penelitian ini yaitu untuk mengetahui adanya aktivitas antibakteri dari ekstrak dan fraksi spons Liosina paradoxa yang diperoleh dari Perairan Pulau Manado Tua terhadap bakteri Staphylococcus aureus dan Escherichia coli.Sampel diekstraksi menggunakan metode maserasi dengan pelarut etanol 95% dan metode fraksinasi. Pengujian aktivitas antibakteri yang dilakukan menggunakan metode difusi agar. Hasil yang didapat dari uji aktivitas antibakteri pada bakteri Escherichia coli memiliki daya hambat bakteri disemua fraksi pada fraksi methanol 8,81mm, fraksi n-Heksan 8,55mm, fraksi kloroform 8,34mm, dan fraki methanol 7,81mm semua fraksi dalam kategori daya hambat sedang, hasil yang sama dengan bakteri Staphylococcus aureus dengan daya hambat kuat pada fraksi n-Heksan dengan daya hambat 10,39mm, dan fraksi methanol 10,23mm, dan daya hambat sedang pada fraksi kloroform 9,69mm dan ekstrak etanol 9,23mm. Ekstrak dan fraksi dari Spons Liosina paradoxa memiliki aktivitas pada bakteri Escherichia coli dan bakteri Staphylococcus aureus.
Non-Specific Standardization Test for Areca Yaki Fruit Extract (Areca Vestiaria) Nadine Natari; Herny Simbala; Erladys Rumondor
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

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The chemical substances contained in the extracts of natural ingredients must be maintained in quality, so standardization is required. This study aims to prove that ethanol extract of Areca yaki Fruit (Areca Vestiaria) meets the non- specific parameters on the standardization of natural ingredients extract. Ethanol extract of Areca Yaki Fruit  is extracted using maceration method. The extracts obtained were tested for several non-specific parameters including desiccant shrinkage, moisture content, total ash content and acid insoluble ash content. The test results are compared with the standard parameters. Areca Yaki Fruit ethanol extract has a drying shrinkage of 0.027%, moisture content of 0.5242%, total ash content of 0.712% and 0.883%, and insoluble acid ash content of 0.048% and 0.056%. Areca Yaki Fruit ethanol extract meets the standard parameters, desiccant shrinkage, moisture content, total ash content, and insoluble acid ash content.
Antibacterial Activity of Ethanol Extract of Areca Vestiaria Leaves (Areca vestiaria) against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa bacteria Wiranatika Jhonatan Sangkoy; Herny Simbala; Erladys Rumondor
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

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WIRANATIKA SANGKOY. Antibacterial Activity of Ethanol Extract of Areca Vestiaria Leaves (Areca vestiaria) against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa bacteria. Under the guidance of HERNY EI SIMBALA as a leader and ERLADYS RUMONDOR as a member.One of the native plants of Indonesia that is widespread in several areas in Indonesia that has the potential to be developed in research testing antibacterial activity is the areca yaki leaf plant. This study aimed to determine the antibacterial activity of areca yaki (Areca vestiaria) leaves against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa at concentrations of 20%, 40%, and 60%. This research was conducted using the Kirby-Bauer method. From the results of this study, the data obtained that concentrations of 20%, 40%, and 60% of Staphylococcus aureus and Escherichia coli bacteria are concentrations that are included in the moderate group, while Pseudomonas aeruginosa at a concentration of 20% is included in the strong group and 40% and 60% are only included in the moderate group.
POTENTIAL OF RED FRUIT (PANDANUS CONOIDEUS CAROTEN LAMK) PAPUA BASED ON LITERATURE REVIEW Hermelina Yosephina Burdam; Herny Simbala; Erladys Rumondor
PHARMACON Vol. 12 No. 1 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

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                              ABSTRACRed fruit plant (Pandanus conoideus Lamk) Papua. is an endemic plant that can grows in almost all areas of Papua, from the lowlands to the highlands. Red Fruit (Pandanus conoideus Lamk,) belongs to the Pandanus family. This plant is widely available Find in Papua, Papua New Guinea, And This Research Aims To know the potential of red fruit (Pandanus conoideus Lamk) Papua based on literature review, research It Uses Qualitative Descriptive Method Aims to Draw, Describe, Explain, Explain, and answer in detail the research results. Based on literature review, red fruit has potential As Socio-Economic Value, As Traditional Medicine, Cure Cancer And tumors, HIV/Aids,High Blood Pressure, Gout, Stroke, Eye Disorders, Osteoporosis, Diabetes Mellitus, Increases Sperm Production in Men, Increases Intelligence, As a Food Source, As Antioxidant, Antidiabetic, Anti-Inflammatory Antibacterial Cardiovascular, Hypertension 
A SPONGE (Stylissa sp.) ANTIOXIDANT TEST COLLECTED FROM MANADO BAY: UJI AKTIVITAS ANTIOKSIDAN (Stylissa sp.) YANG DIPEROLEH DARI TELUK MANADO Billy Arthur Porajow; Adithya Yudistira; Erladys Rumondor
PHARMACON Vol. 12 No. 2 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.38357

Abstract

The Stylissa sp. were under the sea, and these sponge contains active compound, wich are more active than the compounds produced by teresterial plants. The purpose of this study was intended to test the antioxidant activity of the stylissa sp. Sample of the stylissa sp sponge was from the territorial of manado bay. This research an experimental laboratory by testing the ethanol extract of Stylissa sp sponge using DPPH method (1.1-diphenil-2- pikrhydrazil) to analyze antioxidant activity using spectrophotometri uv-vis with variations in concentrations 2, 4, 6, 8, and 10mg/ L. Was extracted Stylissa sp, sponge by maceration using ethanol 95% as a solvent. The value results of % inhibisi (2mg/ L); 86.50% (4mg/ L); 90.5% (6mg/L); 90.53% (8mg/ L) and 90,83% (10mg/L). The highest antioxidant activity at 10mg/L concentration with mean precentage 90.83% inhibisi. The result for this study indicate that the extract from ethanol Stylissa sp sponge has highest antioxidant activity. Keywords: Antioxidant, DPPH, Stylissa sp., bay of Manado
Co-Authors Adithya Yudistira Billy Arthur Porajow Brian G. A. Adilan Defny Wewengkang Hermelina Yosephina Burdam Herny Simbala Ira Handayani Puspita Prins Komang Ayu May Widyani Melisa Oktafiani Makalunsenge Nadine Natari Wiranatika Jhonatan Sangkoy