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Haidy Lailatun Nabila
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology

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Pengaruh Ekstrak Etanol Tangkai Begonia multangula Blume Terhadap Biofilm Bakteri Aggregatibacter actinomycetemcomitans Haidy Lailatun Nabila
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1617

Abstract

Aggressive periodontitis is a type of peridontitis with rapid disease progression and destruction. One of the causes of aggressive periodontitis is the presence of Aggregatibacter actinomycetemcomitans biofilm. Prevention of biofilm formation is one way to prevent aggressive periodontitis. The stalk of B. multangula Blume has antibacterial activity and has the potential to be used as an antibiofilm. This research aimed to determined antibiofilm activity of etanol extract of the stalk B. multangula Blume against A. actinomycetemcomitans.. This research used 5 concentration of extract (6,25%, 12,5%, 25%, 50% and 100%), Negative Control (Aquades sterile) and Positive Control (CHX 0,2%). Inhibition biofilm test using microtitter plate biofilm assay with crystal violet staining at anaerobic incubation for 24 hours and using microplate reader at 620 nm. One way ANOVA and post hoc LSD were used to analyze the differences in antibiofilm activity. The result showed inhibition biofilm activity of A. actinomycetemcomitans by the extract increased as increasing of the concentration. The highest biofilm inhibition was at 100% (74,92%) of the extract concentration and Minimum Biofilm Inhibition Concentration 50 (MBIC50) against A. actinomycetemcomitans was found at 25% (54,42%) of the extract concentration. There were significant difference (p≤0,05) between treatment group of etanol extract (concentration 6,25%, 12,5%, 25%, 50%, and 100%) with negative control and there were no significant difference (p≥0,05) in the positive control with 50% and 100% of the extract concentration. This study concluded that there was an antibacterial activity etanol extract of the stalk B. multangula Blume against inhibition biofilm of A. actinomycetemcomitans.
PREDICTION OF THE ROLE OF CURCUMINOIDS IN CURCUMA LONGA AS GSK-3 INHIBITORS ON TERTIER DENTIN GROWTH Naila Robbaniyya Fithriyya; Hanifah Nur Syafa; Dwi Cinthya Financia; Nadya Elsa Cahyaningrum; Husni Rama Wijayanti; Haidy Lailatun Nabila; Salma Kaltsum Kayana; Ghaida Humaira Susilo Putri; Nurul Hasanah Tanjung; Pratiwi Nur Widyaningsih; Ryana Budi Purnama; Tirta Wardhana
Medical and Health Journal Vol 1 No 1 (2021): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (393.008 KB) | DOI: 10.20884/1.mhj.2021.1.1.4642

Abstract

Caries is one of the most common oral diseases. Tertiary dentin regeneration has recently been developed as an alternative treatment for caries. Curcuminoids are known to have the ability to inhibit GSK-3β in the Wnt signalling pathway to accelerate the formation of reparative dentin. This study aimed to investigate curcuminoids as GSK-3β inhibitors in modulating tertiary dentin formation through the Wnt pathway. Insilico analysis has been carried out using an online database and software. Data collection is done through the Protein Data Bank https://www.rcsb.org/ dan PubChem https://pubchem.ncbi.nlm.here.gov/. The analysis of interactions between proteins and bioactive compounds through the STITCH website http://stitch.embl.de/ dan STRING https://string-db.org/.The results obtained that STK3 protein that binds to curcuminoids has a hippo signalling pathway that inhibits GSK-3β in the Wnt pathway. The study concludes that curcuminoids have the potential to accelerate the development of tertiary dentin.
AKTIVITAS ANTIBAKTERI EKSTRAK TANGKAI Begonia multangula Blume TERHADAP PERTUMBUHAN Aggregatibacter actinomycetemcomitans Dwi Nur Indah Sari; Christiana Cahyani Prihastuti; Restian Febi Andini; Aldina Gusri; Muhammad Hisyam Ghani; Haidy Lailatun Nabila
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.8594

Abstract

Periodontitis adalah penyakit gigi dan mulut yang paling sering ditemukan pada masyarakat dan dapat menyebabkan tanggalnya gigi. Salah satu bakteri penyebab periodontitis adalah Aggregatibacter actinomycetemcomitans. Perawatan periodontitis dilakukan dengan terapi mekanik (scaling and root planning) disertai terapi kimiawi (antibiotik dan obat kumur). Penggunaan terapi kimiawi yang berkepanjangan dapat menyebabkan resistensi bakteri, gangguan pengecapan dan perubahan warna gigi. Alternatifnya dapat digunakan bahan herbal yang memiliki daya antibakteri Tangkai Begonia multangula Blume di beberapa wilayah digunakan sebagai tanaman obat serta memiliki aktivitas antibakteri. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak tangkai Begonia multangula Blume terhadap pertumbuhan A. actinomycetemcomitans secara in vitro. Penelitian dilakukan secara eksperimental laboratoris dengan sampel A. actinomycetemcomitans ATCC 43718. Tangkai Begonia multangula Blume diekstraksi menggunakan metode maserasi dan dibuat 5 seri konsentrasi (3,12%, 6,25%, 12,5%, 25%, dan 50%). Uji antibakteri dilakukan metode difusi kertas cakram dengan kontrol positif Chlorhexidine gluconate 2% serta kontrol negatif DMSO 1%. Diameter zona hambat selanjutnya dianalisis statistic. Hasil penelitian menunjukkan bahwa aktivitas antibakteri ekstrak tangkai Begonia multangula Blume meningkat seiring peningkatan konsentrasi dengan aktivitas tertinggi pada konsentrasi 50% dengan zona hambat sebesar 20,33 mm (p<0,05). Simpulan dalam penelitian ini bahwa ekstrak etanol tangkai Begonia multangula Blume memiliki aktivitas sebagai antibakteri A. actinomycetemcomitans.
Co-Authors Aldina Gusri Christiana Cahyani Prihastuti Dwi Cinthya Financia Dwi Nur Indah Sari Ghaida Humaira Susilo Putri Hanifah Nur Syafa Husni Rama Wijayanti Muhammad Hisyam Ghani Nadya Elsa Cahyaningrum Naila Robbaniyya Fithriyya Nurul Hasanah Tanjung Pratiwi Nur Widyaningsih Restian Febi Andini Ryana Budi Purnama Salma Kaltsum Kayana Tirta Wardhana