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All Journal Jurnal Kedokteran Brawijaya Journal of Innovation in Community Empowerment (JICE)
Yudhi Wibowo
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Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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Combination of Vitamin C and E Improves Spermatogenesis of White Male Rat Model of Paradoxical Sleep Deprivation Stress Fitranto Arjadi; Mustofa Mustofa; Yudhi Wibowo; Nur Signa Aini Gumilas; Dzicky Rifqi Fuadi
Jurnal Kedokteran Brawijaya Vol. 32 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.01.2

Abstract

Paradoxical Sleep Deprivation (PSD) elevates glucocorticoid and Reactive Oxygen Species (ROS) levels that cause oxidative stress, trigger spermatogenic cells damage, and reduce the number of sertoli cells. Vitamin C and E are antioxidants that could prevent spermatogenesis damage by preventing free radical formation. The study aimed to determine the effect of single and combined doses of vitamin C and E in improving spermatogenesis of white male rats (Rattus norvegicus) model of PSD. This is experimental research with post-test only and control group design on 28 white male rats distributed into four groups, i.e. group I (control, PSD), group II (PSD+vitamin C), group III (PSD+vitamin E), and group IV (PSD+a combination of vitamin C and E). Testicular preparations were stained using Hematoxylin-Eosin staining, quantitative scores of spermatogenic cells were measured using the Johnsen method, and the number of sertoli cells was counted in 10 seminiferous tubules in each of the three testicular sections. Group I has the lowest mean of Johnsen score (5.27±0.28), and group IV has the highest mean score (8.95±0.62), while the Mann-Whitney test showed a significant difference (p<0.05) between group II, III and IV compared to group I (control group). Mean sertoli cells number of group I is the lowest (10.66±1.04), and group IV has the highest sertoli cells number. The post-hoc LSD test showed a significant difference (p<0.05) between group IV and the other groups. Thus, the combination of vitamins C and E improves Johnsen score and sertoli cells number of male rats (Rattus norvegicus) experiencing PSD.
Sosialisasi Peningkatan Pengetahuan dan Praktik Pencegahan dan Penanggulangan Covid-19 Di Kelurahan Rejasari, Purwokerto Barat Yudhi Wibowo; Nendyah Roestijawati; Joko Mulyanto; Dyah Krisnansari; Siti Munfiah; M Fikri Marhadhani; Machfira Bulantrisna
The Journal of Innovation in Community Empowerment Vol 4 No 1 (2022): Journal of Innovation in Community Empowerment (JICE)
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jice.v4i1.663

Abstract

ABSTRAK Per tanggal 21 November 2020, di Kabupaten Banyumas, tercatat 1.341 kasus dan 43 kasus kematian. Di Kec. Purwokerto Barat tercatat 64 kasus dan di Rejasari tercatat 13 kasus dengan kematian 2 orang. Kelurahan Rejasari berada di Kecamatan Purwokerto Barat, terdiri dari 9 RW dan RW 3 merupakan kantong masyarakat tidak mampu yaitu 263 KK dari 391 KK termasuk keluarga pra-sejahtera. Upaya memutus rantai penularan covid-19 melalui 3M. Pengetahuan dan sikap masyarakat sangat mempengaruhi kepatuhan terhadap upaya pencegahan dan pengendalian covid-19. Tujuan kegiatan ini adalah meningkatkan pengetahun dan praktik pencegahan dan penangulangan covid-19. Metode dengan penyuluhan, simulasi dan praktik menggunakan masker dan cuci tangan menggunakan hand sanitizer yang benar sesuai ketentuan. Hasil uji Firedman dan Post Hoc Wilcoxon didapatkan peningkatan pengetahuan sebelum penyuluhan dibandingkan setelah penyuluhan, evaluasi 1 dan 2 serta berbeda signifikan secara statistik (p=0,005, p=0,032 dan p=0,043). Untuk sikap tidak berbeda signifikan secara statistik sebelum penyuluhan dengan setelah penyuluhan, evaluasi 1 dan 2 (p=0,393) dengan uji Friedman. Implikasinya bahwa penyuluhan meningkatkan pengetahuan peserta tentang covid-19. Simpulan bahwa masyarakat perlu diberi penyuluhan dan role model disiplin protokol kesehatan.
Co-Authors Dyah Krisnansari Dzicky Rifqi Fuadi Fitranto Arjadi Joko Mulyanto M Fikri Marhadhani Machfira Bulantrisna Mustofa Mustofa Nendyah Roestijawati Nur Signa Aini Gumilas Siti Munfiah