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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Berkala Ilmu Kesehatan Kulit dan Kelamin Pharmascience Journal of Community Empowerment for Health JKKI : Jurnal Kedokteran dan Kesehatan Indonesia

Febriana, Sri Awalia

Departemen Dermatologi Dan Venereologi Fakultas Kedokteran, Kesehatan Masyarakat, Dan Keperawatan Universitas Gadjah Mada Yogyakarta

Author-ID : 5624549

Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Articles

ANALISIS COST OF ILLNESS DAN LAMA RAWAT INAP PADA PASIEN STEVENS JOHNSON SYNDROME DAN TOXIC EPIDERMAL NECROLYSIS DARI PERSPEKTIF RUMAH SAKIT DI RSUP DR. SARDJITO YOGYAKARTA Darwis Darwis; Dyah Aryani Perwitasari; Sri Awalia Febriana
Media Farmasi: Jurnal Ilmu Farmasi Vol 16, No 2: September 2019
Publisher : Universitas Ahmad Dahlan

Stevens-Johnson Syndrom (SJS) dan Toxic Epidermal Necrolysis (TEN) merupakan suatu reaksi hipesensitivitas akut ditandai dengan nekrosis kutaneus dan masuk 10 besar efek samping terbanyak yang dilaporkan di Indonesia sebesar 3%. Banyaknya terapi dan lama perawatan diRumah sakit berdampak pada meningkatnya morbiditas, mortalitas dan biaya kesehatan. Tujuan dari penelitian inia adalah mengetahui cost of illness dan perbandingan lama rawat inap pada pasien SJS dan TEN akibat penggunaan obat dari perspektif rumah sakit. Design penelitian iniadalah cross sectional study dengan pengambilan data retrospektif. Data yang diambil adalah pasien yang terdiagnosa SJS dan TEN akibat penggunaan obat dan menjalani rawat inap di RSUP Dr. Sardjito Yogyakarta selama periode tahun 2014-2018 sesuai kreteria inklusi daneksklusi. Sebanyak 48 pasien dilibatkan dengan diagnosa SJS sebanyak 41 pasien dan TEN sebanyak 7 pasien. Rata-rata total biaya pasien SJS sebesar Rp. 16.546.233,0224±16.091.819,01889, sedangkan untuk pasien TEN sebesar 14.356.586,2086 ± 6.645.740,75924. Rata-rata lama rawat inap pasien SJS (12,66±5,77 hari) dan TEN (13,29±3,03 hari). Tidak terdapat perbedaan signifikan rata-rata total biaya dan lama rawat inap antar pasien SJS dan TEN dimana nilai p > 0,05. SJS dan TEN tidak terdapat perbedaaan signifikan tetapi dapat menjadi beban biaya cukup tinggi dan peningkatan durasi lama rawat inap bagi pasien.

ANALISIS BIAYA SAKIT PERSPEKTIF MASYARAKAT PADA PENDERITA DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) DI RSUP Dr. SARDJITO YOGYAKARTA Musa Fitri Fatkhiya; Dyah Aryani Perwitasari; Sri Awalia Febriana
Media Farmasi: Jurnal Ilmu Farmasi Vol 17, No 1: Maret 2020
Publisher : Universitas Ahmad Dahlan

Penyakit akibat induksi obat merupakan suatu efek yang tidak diinginkan yang dapat menyebabkan mortalitas maupun morbiditas. Reaksi pada kulit yang mungkin muncul dapat berupa efek ringan hingga berat seperti Severe Cutaneous Adverse Reaction (SCAR) sehingga memerlukan perhatian khusus. SCAR bukan hanya masalah kesehatan tetapi juga menjadi beban keuangan yang signifikan untuk individu yang terkena dampak. Salah satu variasi SCAR yang memiliki periode latensi yang panjang adalah DRESS (Drug Reaction With Eosinophilia and Systemic Symptom). Penelitian ini bertujuan untuk mengetahui rata-rata biaya medis langsung, biaya non medis langsung dan biaya tidak langsung pada pasien DRESS. Pengambilan data dalam penelitian ini secara cohort retrospective di RSUP Dr. Sardjito Yogyakarta tahun 2015-2018 pada pasien DRESS akibat induksi NSAID, antibiotik, antikonvulsan, antiretroviral, antituberkulosis berdasarkan data rekam medis, data akuntansi serta CRF. Hasil data dianalisis secara deskriptif dengan Microsoft office excel. Rata-rata biaya medis langsung rawat inap sebesar Rp. 11.643.405 dengan komponen biaya tertinggi adalah biaya obat (31%), biaya tindakan medis (27%), biaya laboratorium (24%), biaya akomodasi (15%) dan biaya lainnya (3%). Biaya rawat jalan sebesar Rp. 1.027.894 dengan komponen tertinggi yaitu biaya tindakan medis (39%), biaya laboratorium (36%), biaya obat (14%), biaya lainnya (6%) dan terendah adalah biaya transportasi (5%). Rata-rata biaya non medis langsung sebesar Rp 491.035 dan biaya tidak langsung adalah sebesar Rp. 1.675.369 yang merupakan biaya loss income. Biaya medis langsung merupakan biaya tertinggi dibandingkan biaya non medis langsung dan biaya tidak langsung.

Analisis Cost Of Illness Drug Reaction With Eosinophilia Systemic Symptoms Di RSUP Dr.Sardjito Yogyakarta Vicryanto Halid; Dyah Aryani Perwitasari; Sri Awalia Febriana
Jurnal Pharmascience Vol 7, No 1 (2020): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8073

ABSTRAK Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) adalah reaksi alergi kulit dengan demam, kenaikan eosinofil darah dan komplikasi organ. Sulitnya diagnosa dan lama terapi serta berpotensi kekambuhan membuat DRESS menjadi masalah karena mempengaruhi ekonomi. Cost of illness (COI) merupakan analisis menentukan beban ekonomi penyakit yang terdiri dari beberapa perspektif. Penelitian ini bertujuan mengetahui total COI dari perspektif Rumah sakit berdasarkan jenis DRESS, jenis obat, dan jumlah obat penyebab DRESS. Penelitian non-experimental dengan desain cross-sectional retrospektif. Subyek penelitian 21 pasien. Parameter biaya komponen biaya medis langsung yaitu biaya instalasi gawat darurat, pengobatan, monitoring, penunjang dan rawat jalan. Hasil analisis data berupa median (range). Median total COI DRESS dengan komplikasi organ adalah Rp.13.194.963 dan Rp.10.123.495 untuk pasien DRESS tanpa komplikasi organ. Antibiotik menjadi obat penyebab DRESS terbanyak (55,55%) dengan range total biaya tertingginya Rp.53.576.350. Kesimpulan: Total COI DRESS di RSUP Dr.Sardjito tahun 2014-2018 satu pasien adalah Rp.13.546.700.Kata Kunci: Drug Reaction with Eosinophilia and Systemic Symptom, Cost OF illness, biaya medis langsung, komplikasi organ, perspektif Rumah sakit. ABSTRACT Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) are allergic skin reactions with fever, elevated blood eosinophils and organ complications. Difficult diagnosis and duration of therapy and potential recurrence make DRESS a problem because it affects the economy. Cost of illness (COI) is an analysis determining the economic burden of a disease consisting of several perspectives. This study aims to determine the total COI from the perspective of the hospital based on the type of DRESS, the amount and type of causative drug of DRESS. Non-experimental research with a retrospective cross-sectional design. Study subjects 21 patients. The cost parameters of the direct medical component costs are the costs of the emergency department, treatment, monitoring, support and outpatient care. The results of data analysis are in the form of a median (range). Results: The total median of COI DRESS with organ complications was Rp.13,194,963 and Rp.10,123,495 for DRESS patients without organ complications. Antibiotics became the most common drug causing DRESS (55.55%) with the highest total cost range of Rp.53,576,350. Conclusion: Total COI DRESS at Dr.Sardjito General Hospital in 2014-2018 one patient was Rp.13,546,700. Keywords: Drug Reaction with Eosinophilia and Systemic Symptom, Cost of Illness, direct medical costs, organ complications, perspective of the hospital.

Analisis Cost of Illness Stevens Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis (TEN) Qarriy Aina Urfiyya; Dyah Aryani Perwitasari; Sri Awalia Febriana
Jurnal Pharmascience Vol 7, No 1 (2020): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8077

ABSTRAK SJS/TEN merupakan reaksi yang melibatkan kulit dan mukosa yang berat dan mengancam jiwa. SJS dan TEN merupakan kejadian yang jarang terjadi, yaitu 1,4 – 12,7 kasus per 1 juta orang per tahun mengalami SJS dan TEN, dengan angka mortalitas 5% pada SJS dan 30-35% pada TEN. Obat merupakan penyebab utama SJS (50-80% dari kasus) dan TEN (80%). Tujuan: Mengetahui median total biaya per hari pasien SJS/TEN, serta pengaruh lama rawat inap terhadap total biaya SJS/TEN. Penelitian observasional analitik dengan sudut pandang masyarakat. Pengambilan data secara retrospektif menggunakan total sampling pasien rawat inap SJS dan TEN di RSUP Dr. Sardjito Yogyakarta tahun 2014-2018. Analisis data dengan menghitung median (range) dan regresi linear pada SPSS IBM versi 22.0 untuk mengetahui pengaruh lama rawat inap terhadap biaya SJS/TEN. Terdapat 29 pasien yang dianalisis. Median total biaya per hari pasien SJS/TEN Rp 1.139.963 (Rp 665.294-Rp 8.776.895), dengan Rp 1.139.963 (Rp 740.267-Rp 8.776.895) pada SJS dan Rp 1.166.084 (Rp 665.294-Rp 1.514.607) pada TEN. Hasil signifikansi uji regresi linear lama rawat inap terhadap total biaya SJS/TEN adalah 0,093 (p>0,05). Median biaya per hari SJS/TEN adalah Rp 1.139.963 (Rp 665.294-Rp 8.776.895), dan lama rawat inap tidak mempengaruhi total biaya SJS/TEN. Kata Kunci—Stevens Johnson Syndrome, Toxic Epidermal Necrolysis, analisis biaya, cost of illness ABSTRACT SJS/TEN is a reaction that involves heavy and life-threatening skin and mucosa. SJS and TEN are rare events, 1,4 – 12,7 cases per 1 million people per year experiencing SJS and TEN, with a mortality rate of 5% in SJS and 30-35% in TEN. Drugs are the main cause of SJS (50-80% of cases) and TEN (80%). Objective: To determine the median total cost per day of SJS and TEN patients, and the effect of length of stay on the total cost of SJS/TEN. This study used an observational analytic with cross sectional design and societal perspective. The data was collected retrospectively using total sampling of SJS and TEN inpatients at RSUP Dr. Sardjito Yogyakarta in 2014-1018. The data was analyzed by calculating the median (range) and linear regression in IBM SPSS version 22.0, to determine the effect of length of stay on SJS/TEN costs . There were 29 patients analysed. The median total cost per SJS/TEN patient was IDR 1.139.963 (IDR 665.294-8.776.895), with IDR 1.139.963 (IDR 740.267-8.776.895) on SJS and IDR 1.166.084 (IDR 665.294-1.514.607) on TEN patients. The significance linear regression of the length of stay in SJS/TEN was 0,093 (p> 0,05). The median cost per SJS/TEN day was IDR 1.139.963 (665.294-8.776.895), and the length of stay does not affect the total cost of SJS/TEN. Keywords— Stevens Johnson Syndrome, Toxic Epidermal Necrolysis, cost analysis, cost of illness

Efektivitas Penambahan Terapi Klindamisin dengan Peeling Asam Laktat dan Iontoforesis Natrium Bikarbonat pada Akne Vulgaris Niken Kusumaningrum; Sri Awalia Febriana; Dwi Retno Adi Winarni
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 31 No. 3 (2019): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Latar Belakang: Akne vulgaris merupakan masalah jangka panjang, sehingga memerlukan waktu terapi yang lama. Terapi tambahan diperlukan untuk mencegah resistensi antibiotik topikal. Peeling asam laktat dan iontoforesis natrium bikarbonat merupakan modalitas terapi yang dapat digunakan sebagai terapi tambahan.Tujuan: Penelitian dilakukan untuk mengevaluasi efektivitas terapi klindamisin gel 1% dengan penambahan peeling asam laktat 40% dan iontoforesis natrium bikarbonat 8,4% pada akne vulgaris derajat ringan sampai sedang. Metode: Penelitian ini merupakan single blind randomized controlled trial, subjek siswa laki-laki Sekolah Menengah Kejuruan Negeri (SMKN) 3 Yogyakarta dengan akne vulgaris derajat ringan-sedang berusia 18-19 tahun. Subjek dibagi dalam 3 kelompok (masing-masing 23 orang) secara acak, yaitu (A) terapi peeling asam laktat 40% dan klindamisin gel 1%; (B) terapi iontoforesis natrium bikarbonat 8,4% dan klindamisin gel 1%; dan (C) kontrol dengan terapi standar klindamisin gel 1%. Efektivitas terapi dinilai berdasarkan penurunan jumlah lesi akne pada pengamatan selama 4 minggu. Hasil: Penambahan terapi klindamisin dengan peeling asam laktat dan iontoforesis natrium bikarbonat pada akne vulgaris derajat ringan-sedang efektif menurunkan lesi komedo tertutup (p<0,05), namun perbandingan efektivitas penambahan peeling asam laktat dan iontoforesis natrium bikarbonat tidak berbeda bermakna (p>0,05). Simpulan: Penambahan terapi klindamisin dengan peeling asam laktat dan iontoforesis natrium bikarbonat efektif menurunkan lesi akne vulgaris derajat ringan-sedang. Tidak terdapat perbedaan efektivitas peeling asam laktat dibandingkan iontoforesis natrium bikarbonat sebagai terapi tambahan topikal klindamisin gel untuk akne vulgaris derajat ringan-sedang.

Profil penyakit kulit pada pelajar sekolah asrama di Kabupaten Magelang, Jawa Tengah Tuntas Rayinda; Devi Artami Susetiati; Sri Awalia Febriana
Journal of Community Empowerment for Health Vol 1, No 2 (2019)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Individuals who live in boarding schools often experience various skin diseases, both infection and non-infectious because of exposure to various risk factors such as hormonal changes, poor hygiene and sanitation, and dense living quarters. To date, data on the prevalence of disease in adolescents in boarding schools are still very limited. This study is an observational cross-sectional study that aims to describe skin diseases that often occur in adolescents who live in boarding schools. Surveys and clinical examinations are carried out by dermatologist. Based on a survey of 1,250 students aged 10 - 16 years, 1,073 students (85.8%) had at least one skin disease. A total of 1,073 cases from 27 different types of skin diseases were found in these students. The five most common skin diseases are dermatophytosis, scabies, acne vulgaris, ecthyma, and pityriasis versicolor. Education, periodic surveys, mass treatment, and interventions to improve hygiene and living conditions are key to success in the management of skin diseases in students living in boarding schools.

Karakteristik limbah dan dampaknya bagi kesehatan pembatik di Lendah, Kulon Progo Suhartini - suhartini; Sri Awalia Febriani; IBG. Surya Putra Pidada; Hendro Widagdo; Martiana Suciningtyas; Yudha Nurhantari; Dewanto Yusuf Priyambodo; Agus Surono; Roto Roto; Geraldine Nadita Putri Kinasih; Pramudji Hastuti; Sri Sutarni
Journal of Community Empowerment for Health Vol 2, No 2 (2019)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.42250

Synthetic batik coloring often uses heavy metals element such as lead (Pb), chromium (Cr),silica (Si), and hydrochloric acid (HCl). The exposure of heavy metals in long period results in health impair on the artisans and eventually harming the environment. The purpose of this research is to analyze the waste characteristics and health impact towards the artisans in the Lendah, Kulon Progo. Seventy-six batik artisan, consisting of 37 from SB, 20 from FA, and 19 from SA underwent 5 ml blood sampling. The samples were used to determine their hemoglobin (Hb) level, packed cell volume (PCV), blood sugar, and total cholesterol. Blood plasma and wastewater were examined for Pb and Cr using the inductively coupled plasma (ICP) method; Si using atomic absorption spectrophotometry (AAS); and Cl- using spectrophotometry. Respondents underwent health checks and were interviewed about the impact of waste and disease complaints experienced using a questionnaire. Cognitive disorders were examined using mini-mental state examination (MMSE) and peripheral neuropathy was assessed using diabetic neuropathy symptom (DNS) score. The results obtained were analyzed by analysis of variance and t-test. Correlation test was used to examine the relationship of Pb and Cr with cognitive disorders. Total cholesterol levels and blood sugar were analyzed descriptively. There is no difference in knowledge about waste in batik makers in SB, FA, and SA. The level of Pb, Cr, and Cl- within the three production centers showed no significant difference (p > 0,05), whilst Si level showed significant difference between centers (p < 0,05). There is no correlation between Pb and Cr blood levels with cognitive impairing according to MMSE and occurence of peripheral neuropathy according to DNS score (p > 0.05). Normal cholesterol levels (< 200mg/dL) andnormal blood glucose levels (< 200 mg/dL) were observed in 70.0-80.5% and 85.0-95.1% batik artisans, respectively. Si levels in all three production centers’ waste shows significant difference. The most frequent complaint was back pain and dizziness. There is no correlation caused by Pb and Cr levels toward cognitive impairing. Cholesterol level in batik artisans tended to be high.

The effectiveness of personal preventive measures against occupational contact dermatitis in healthcare workers: A systematic review Khansa Maria Salsabila; Sri Awalia Febriana; Retna Siwi Padmawati; Retno Danarti
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 2, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss2art12

Healthcare workers (HCWs) embody the principles of hand hygiene and protective attire to support self- and patient safety, but the materials involved in this process are found to be offending agents. The incidence of occupational contact dermatitis (OCD) among HCWs keeps increasing. This review aimed to evaluate the effectiveness, investigate the outcome and clinical skin condition improvement with the implementation of primary preventive measures (PPM), specifically: barrier cream, emollient, moisturiser, gloves use, and education. All relevant literature about PPM against OCD among HCWs published between 1995 to 2020 was searched. The data search was performed using the PUBMED, Cochrane Library, and ScienceDirect databases. There were 16 studies comprised of 8 randomised controlled trials (RCTs), 7 clinical trials, and one comparative study. The study results showed that using barrier cream, moisturiser or emollient, gloves, and education were effective tools in reducing the number of clinical symptoms in cases of OCD. There was no significant difference in the effect between barrier cream use and moisturiser or emollient. The gloves were advised to be used non-latex gloves or powder-free latex gloves. Education was also observed to improve preventive behaviour among workers. The use of barrier cream, emollient, moisturiser, and gloves is recommended to be educated to ascertain the proper use of preventive measures, increase knowledge and awareness, and promote positive preventive behaviour.

The facial measurements in health workers at Dr. Sardjito General Hospital, Yogyakarta Nadiya Husna Aliya; Neni Trilusiana Rahmawati; Janatin Hastuti; Sri Awalia Febriana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005502202306

The appropriate mask is based on facial anthropometric measurements that may be affected by sex, race, age, and body mass index (BMI). This study aimed to determine the difference and relationship between the bizygomatic width (BW) and nasion-menton height (NMH) with sex and BMI in health workers. This descriptive-analytical study used a cross-sectional method. The subjects were 39 health workers (nurses and doctors) at Dr. Sardjito General Hospital, Yogyakarta consisting of 15 male subjects and 24 female subjects, aged between 25-55 years old. Anthropometric measurements were performed on the subjects, including body weight, height, NW, and NMH. The data were analyzed using the Shapiro-Wilk test, independent t-test, and Pearson’s test. There was a significant difference in the BW between male and female subjects (p<0.05), with the males’ BW (13.1 ± 0.76 cm) being larger than that of the female subjects (12.35 ± 0.62 cm). There were no differences in the BMI and nasion-menton height between the male and female subjects (p>0.05). The Pearson’s test results showed no significant relationship between the BW with BMI in both the male subjects (r=0.351; p=0.199) and the female subjects (r=0.349; p=0.094), and between the nasion-menton height with BMI in both the male subjects (r=0.101; p=0.721) and the female subjects (r=0.390, p=0.060). In conclusion, the males’ BW was larger than the female health workers. It is necessary to consider facial anthropometric measurements in face mask manufacturing to provide comfort and good protection.

Co-Authors Agus Surono Darwis Darwis Devi Artami Susetiati Dewanto Yusuf Priyambodo Dyah Aryani Perwitasari Dyah Aryani Perwitasari Dyah Aryani Perwitasari Geraldine Nadita Putri Kinasih Hendro Widagdo IBG. Surya Putra Pidada Janatin Hastuti Khansa Maria Salsabila Martiana Suciningtyas Musa Fitri Fatkhiya Nadiya Husna Aliya Neni Trilusiana Rahmawati Niken Kusumaningrum Pramudji Hastuti Qarriy Aina Urfiyya Retna Siwi Padmawati Retno Danarti Roto Roto Sri Sutarni Suhartini - suhartini Tuntas Rayinda Vicryanto Halid Winarni, Dwi Retno Adi Yudha Nurhantari

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