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All Journal Jurnal Kesehatan Hesti Wira Sakti Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Riset Kefarmasian Indonesia HERBAPHARMA : Journal of Herb Farmacological JIC (Jurnal Insan Cendekia) Pharmademica: Jurnal Kefarmasian dan Gizi
aprilianti, rakhmadani gadis
Program Studi Vokasi Farmasi, ITSK RS Dr.Soepraoen Kesdam V/Brawijaya, Malang, 65147, Indonesia.
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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GAMBARAN INTERAKSI OBAT PENYAKIT JANTUNG KORONER DENGAN SINDROM METABOLIK PADA PASIEN RAWAT JALAN DI RS TK II DR. SOEPRAOEN MALANG Aprilianti, Rakhmadani Gadis; Sekti, Beta Herilla; Hidayati, Lilik Nur
Jurnal Riset Kefarmasian Indonesia Vol 4 No 1 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i1.222

Abstract

Drug interaction is the effect of a drug that is caused when there are two or more drugs that interact and affect the body's response to treatment. The method used in this study is a descriptive study using a cross-sectional observational method with retrospective observations in October - December 2020. Patient data collection was obtained from patient medical records using a purposive sampling technique with inclusion criteria. A total of 89 patients were taken as samples. Data analysis using MEDSCAPE and drugs.com applications. A total of 82 prescriptions have the potential for drug interactions, where the most significant level of drug interaction is moderate level (81.48%, these include aspirin with candesartan and bisoprolol with amlodipine. The most drug interaction is the interaction between aspirin and bisoprolol which is classified as a minor interaction (17.74%). The most frequently used type of drug is bisoprolol (22.18%) and the most frequently used drug class is beta blocker
PEMANTAUAN RESPON KLINIS PENDERITA EPILEPSI GRAND MALL PADA LANSIA (Geriatri ) YANG MENDAPAT TERAPI FENITOIN DI APOTEK RAWAT JALAN RUMAH SAKIT ”X” Malang rakhmadani gadis aprilianti; beta herilla sekti
Jurnal Kesehatan Hesti Wira Sakti Vol. 7 No. 2 (2019)
Publisher : Institut Teknologi, Sains, dan Kesehatan RS dr. Soepraoen Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47794/jkhws.v7i2.274

Abstract

Pendahuluan Angka prevalensi penderita epilepsi aktif berkisar antara 4-10 per 1000 penderita epilepsi (Beghi dan Sander, 2008). Bila jumlah penduduk Indonesia berkisar 220 juta, maka diperkirakan jumlah penderita epilepsi baru 250.000 per tahun. Rata-rata prevalensi epilepsi 8,2 per 1000 penduduk. Prevalensi epilepsi pada bayi dan anak-anak cukup tinggi, menurun pada dewasa muda dan pertengahan, kemudian meningkat lagi pada kelompok usia lanjut (Perhimpunan Dokter Spesialis Saraf Indonesia (PERDOSSI, 2011). Tujuan dalam penelitian ini untuk mengetahui persentase respon penderita epilepsi tipe grand mall lanjut usia yakni respon toksik berupa hiperplasia gusi, ruam kulit, vertigo, nistagmus, mual, sukar berbicara, ataksia. Penelitian ini bersifat observasional berdasarkan hasil kuesioner pasien epilepsi di apotek rawat jalan Rumah Sakit ”X” Malang pada bulan April – Oktober tahun 2019. Metode yang digunakan adalah deskriptif untuk melihat gambaran presentasi respon penderita epilepsi tipe grandmall. Instrumen penelitian berupa lembar pengambilan data dan kuesioner. Data akan dianalisis dan di dskripsikan berdasarkan hasil kuesioner. Hasil Berdasarkan hasil penelitian sekitar 27,06 % responden menjawab Ya terjadi efek samping penggunaan fenitoin, sedangkan responden yang menjawab (Tidak) atau responden yang tidak muncul efek samping sesuai dengan kuisioner yaitu (78,94%). Berdasarkan hasil penelitian efek samping yang muncul paling banyak pada responden adalah pusing yaitu terjadi pada 7 responden, efek samping yang juga banyak muncul pada responden diantaranya sempoyongan, berputarnya bola mata secara cepat an sukar bicara yaitu masing masing terjadi pada 6 responden
Analisis Kadar Asam Retinoat dalam Krim Pemutih Malam di Kota Malang Fendi Yoga Wardana; Yunida Senja Lestari; Rakhmadani Gadis Aprilianti
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 1 No 2 (2022): Oktober - Maret
Publisher : LPPMKI - AKAFARMA AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (644.087 KB) | DOI: 10.54445/pharmademica.v1i2.17

Abstract

Whitening cream is a product that is used on the outside of the body to lighten or change the color of the skin. Whitening cream contains chemicals that are harmful to the skin, such as mercury, hydroquinone, and retinoic acid. Retinoic acid belongs to a group of drugs that are prohibited because it can cause dry skin, burning and teratogenicity. Therefore, it is necessary to analyze the retinoic acid in whitening cream. This study aims to determine the content of retinoic acid in night whitening cream. The samples in this study were 5 night whitening cream products marketed in Malang. Qualitative test of retinoic acid was performed by Thin Layer Chromatography (TLC) with silica gel 60F 254 nm as a stationary phase and n-hexane: acetone (6:4) as a mobile phase, and quantitative test using UV-Vis spectrophotometry. The observation result on TLC shows dark blue spots when viewed under UV light at 254 nm with Rf values for samples B, D, and E of 0.487; sample C of 0.425; while the Rf value of the comparison standard is 0.500. The quantitative test indicates 4 samples of night whitening cream contain retinoic acid; 0.165% in sample B, 0.060% in sample C, 0.125% in sample D, and 0.151% in sample E. In conclusion, samples B, C, D and E do not meet the BPOM requirements because they are sold freely without a doctor's supervision.
UJI KANDUNGAN VITAMIN A TANAMAN WORTEL (Daucus Corata L.) DI DESA NGABAB KABUPATEN MALANG Beta Herilla Sekti; Rakhmadani Gadis Aprilianti; Susi Wijiastini
HERBAPHARMA : Journal of Herb Farmacological Vol 3 No 2 (2021): Volume 3 Nomor 2 Desember 2021
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/herbapharma.v3i2.264

Abstract

Carrot plant (Daucus carota L.) is a type of vegetable that contains lots of vitamin A and is very much needed by the body to help regulate or metabolic processes in the body. The research design used in this study was experimental, the population and sample were carrots from Ngabab village aged 3-3.5 months, using purposive sampling technique. The results of the qualitative analysis showed that there were orange spots with an Rf value of 0.64 in the carrot extract and the beta-carotene comparison standard. The results of the quantitative analysis showed that the average level of vitamin A in carrots was 49.7% with an absorbance of 0.649. Keywords: Visible Spectrophotometry, Vitamin A, Carrot.
AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN UNGU (Graptophyllum pictum L. Griff) MENGGUNAKAN METODE DPPH (1,1-DIPHENYL-2-PICRYHYDRAZYL) Beta Herilla Sekti; Rakhmadani Gadis A; Nurfitria Nurfitria
Jurnal Insan Cendekia Vol 9 No 2 (2022): Jurnal Insan Cendekia September 2022
Publisher : STIKES Insan Cendekia Medika Jombang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35874/jic.v9i2.982

Abstract

Pendahuluan: Beberapa senyawa yang terkandung dalam Daun ungu (Graptophyllum pictum L.Griff) antara lain flavonoid, alkaloid, tanin, triterpenoid, fenol dan saponin. Flavonoid berfungsi sebagai antioksidan dengan menstabilkan radikal bebas sehingga dapat mengurangi kerusakan sel karena inflamasi, maka dilakukanlah pengujian aktivitas antioksidan pada ekstrak daun ungu. Tujuan :untuk mengetahui IC50 pada ekstrak daun ungu sebagai antioksidan. Metode : Jenis penelitian ini merupakan penelitian eksperimental. Perhitungan IC50 menggunakan metode spektrofotometri UV-Visibel dengan 1,1-Diphenyl-2-picryhydrazyl (DPPH) pada Panjang gelombang 518 nm dengan standart yang digunakan adalah asam ascorbat. Konsentrasi yang digunakan pada pengujian aktivitas antioksidan ekstrak daun ungu sebesar 105µg/mL, 115µg/mL, 125µg/mL, 135µg/mL, 145µg/mL.Hasil :Pada hasil pengukuran aktivitas antioksidan ekstrak daun ungu diperoleh data berdasarkan nilai IC50 pada konsentrasi 84,91μg/mL. Hasil IC50 yang diperoleh dibandingkan dengan nilai inhibisi larutan Asam Ascorbat dengan variasi konsentrasi sebesar 10μg/mL, 12 μg/mL, 14 μg/mL, 16 μg/mL, 18 μg/mL. Kesimpulan : aktivitas antioksidan dari ekstrak daun ungu tergolong kuat.
Oral Subchronic Toxicity Test of Yellow Root Ethanol Extract (Arcangelisia flava Merr.) In Rats (Mus musculus): Uji toksisitas subkronik oral ekstrak etanol akar kuning (Arcangelisia flava Merr.) pada Mencit (Mus musculus) Rakhmadani Gadis Aprilianti; Tsaniaturrizqiah Permataningtyas; Fendi Yoga Wardana
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 8 No. 2 (2022): (October 2022)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2022.v8.i2.15961

Abstract

Background: Yellow root (Arcangelisia flava Merr.) is a native Indonesian plant that contains alkaloids, phenolics, flavonoids, saponins, tannins and berberine. This plant is proven to have antimicrobial, antioxidant, antihyperlipidemic, and anticancer activity. However, the effect on body weight, clinical symptoms and toxic symptoms has not been studied yet. Objectives: Accordingly, the objective of this research was to determine the effect of Arcangelisia flava Merr. extract with the multilevel maceration method on parameters of body weight, clinical symptoms and toxic symptoms in male rats. Material and Methods: A total of 16 male rats aged 6-8 weeks weighing 20-40 grams were divided into 4 groups. The control group was only given 1% sodium-carboxymethyl cellulose (CMC-Na), while the treatment group was given Arcangelisia flava Merr. extract at doses of 800, 900, and 1000 mg/kgBW orally for 28 days. At week 1 to week 4, body weight, clinical symptoms and toxic symptoms were observed for male rats. Result: Observations of toxic symptoms and symptoms showed that there were several symptoms that appeared in male rats and changes in body weight there were no significant differences from t0 to t1, t0 to t2, t0 to t3, and t0 to t4 for each treatment (p>0,05). Conclusions: The administration of Arcangelisia flava Merr. extract at doses of 800, 900, and 1000mg/kgBW for 28 days did not affect weight gain or loss, but these extracts did have an effect on symptoms in test animals such as straight fur and strange behavior.
Co-Authors Beta Herilla Sekti Hidayati, Lilik Nur Nurfitria Nurfitria Susi Wijiastini Tsaniaturrizqiah Permataningtyas Wardana, Fendi Yoga Yunida Senja Lestari