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Dyah Ratri Anggarini, Dyah Ratri

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Author-ID : 563316

Immunology & microbiology Public Health

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Susceptibility test of Griseofulvin, Ketoconazole, Itraconazole, and Terbinafine to Dermatophyte Species Using Microdilution Method Anggarini, Dyah Ratri; Sukanto, Hari; Astari, Linda; Endraswari, Pepy Dwi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Backgroud: Dermatophytosis is common disease in tropical countries such as Indonesia. The prevalence of dermatophytosis in general population also high (20%). The dermatophyte fungi are the etiologic agents that cause this disease, some of them had already reported to be resistant to some anti-fungi. Purpose: To determine dermatophyte species causing dermatophytosis and the resistancy of griseofulvin, ketoconazole, itraconazole, dan terbinafine to dermatophyte species. Methods: Isolates of dermatophyte from patient who met the inclusion criteria in outpatient clinic of dermato-venereology Dr. Soetomo Hospital Surabaya during October until December 2014 were analyzed with respect to their susceptibility to four anti-fungal agents (griseofulvin, ketoconazole, itraconazole, and terbinafine) using microdilution methode. Results: Thirthy patients were included in inclusion criteria, with T. mentagrophytes var. Interdigitale was the most common cause of dermatophytoses. According to MIC all 30 isolates were already resistant to all anti-fungal agent, except T. rubrum that still sensitive to ketoconazole and 80,Â itraconazole.Â Conclusion: According to MIC 16.7% isolates sensitive to griseofulvin, 23.3% to ketoconazole, 16.7% to 80 itraconazole and 20% to terbinafine.Key word: dermatophyte species, susceptibility test of anti-fungal, microdilution.

Tinea Capitis Kerion Type: A Case Report Anggarini, Dyah Ratri; Setyaningrum, Trisniartami
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Background: Tinea capitis is a superficial fungal infection. Kerion is one of its form, which is an inflammation form due to a hypersensitivity reaction to fungal infection caused by group Mycosporum and Trichophyton. Purpose: To understand the clinical manifestation, species causing agent, and management of tinea capitis.Â Case management: A four-year-old boy, 17 kg, came with a mass on the head, accompanied with pain, fever, and hair loss since 1 week before hospitalization, it appeared after playing with the neighbors pets. General examination showed enlargement of the right preauricular lymph node. Dermatological examination revealed a mass in the head 7 cm in size with pus, partially covered with crust, and there were also warm and pain on palpation. Wood lamp examination was negative, but in potassium hydroxide examination showed spores outside and inside the hair shaft. Result of fungal cultures was T. mentagrophytes. Routine blood tests obtained only leukocytosis, which was 12.390/ÂµL. The patient was treated with griseofulvin, erythromycin, wet dressing, and ketokonazole shampoo. It was shown good results after therapy for 8 weeks. Conclusions: Tinea capitis caused by T. mentagrophytes presenting an inflammatory reaction, causing a fungal infection in the hair shaft. Auxiliary examination for the diagnosis of tinea capitis can be done in various ways, the easiest one is by potassium hydroxide 20% examination, fungal culture is then performed to determine the species causing the infection. Therapeutic use of griseofulvin is still the main choice.Key words: tinea capitis kerion type, T. mentagrophytes, griseofulvin.

Management of Drug Eruption in Dermatovenereology Ward of Dr. Soetomo General Hospital Surabaya: Retrospective Study Anggarini, Dyah Ratri; Prakoeswa, Cita Rosita Sigit
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Background:Â Drug eruption is a skin alteration with or without the involvement of other organ, which appeared after administration of drug at dose used for prevention, diagnosis, or treatment. The mechanism divided into 2 groups, which are type A (can be predicted) and type B (can not be predicted). Purpose:Â To evaluate the management of drug eruption in Dermatovenereology Ward at Dr. Soetomo General Hospital Surabaya. Methods: Retrospective study of drug eruptions patients was performed based on medical records within 2009-2011. Basic data, history of allergies, previous medical history, suspected drugs, diagnosis, and previous treatment were recorded. Results: The largest age group is 25-44 years, ratio of women and men is 1.4: 1, most suspected drugs as the cause of the eruption were paracetamol (59), amoxicillin (23), cefadroxil (17). Most common diagnosis was Steven-Johnson syndrome (SJS) as many as 23.4%, the most widely used treatment was steroids, and the average treatment duration was 10 days. Drug patch test (DPT) was conducted to determine the exact cause of drug eruption as the follow up. Conclusion: Drug eruptions can occur in varying degrees, potential to recur, and life-threatening thus appropriate treatment to prevent it is required. Management included given treatment, patient education regarding drug eruption causes, type of eruption, and DPT to determine the cause of drug eruption.Key words: drug eruptions, management, drug patch test (DPT), retrospective study.

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