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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Case Reports
Sulamsih Sri Budini, Sulamsih Sri
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Kadar TNF- Lesi Kulit dengan Derajat Keparahan Psoriasis Vulgaris Budini, Sulamsih Sri; Cholis, M. Cholis; Rofiq, Aunur
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 1 (2014): BIKKK APRIL 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (253.55 KB) | DOI: 10.20473/bikkk.V26.1.2014.1-7

Abstract

Latar belakang: Peranan TNF- dalam patogenesis terjadinya lesi kulit pada psoriasis sudah banyak diteliti, termasuk pemakaian terapi biologis pada psoriasis dengan bahan yang menghambat TNF- dan sel T. Kegunaan TNF- serum sebagai biomarker aktifitas penyakit psoriasis memberi hasil yang tidak konsisten baik dalam jumlah absolutnya maupun hubungannya dengan respon hasil pengobatan. Tujuan: Mengevaluasi kadar TNF- lesi kulit dengan derajat keparahan penyakit psoriasis. Metode: Desain penelitian adalah potong lintang analitik observasional dengan jumlah sampel duapuluh lima penderita psoriasis vulgaris yang datang ke poli rawat jalan RSUD Dr Saiful Anwar Malang sesuai kriteria inklusi dan eksklusi. Diagnosis ditegakkan berdasarkan pemeriksaan klinis dan histopatologis. Derajat keparahan dievaluasi dengan skor Psoriasis Area Severity Index (PASI), yaitu <10 ringan; 10-20 sedang; dan >20 berat. Kadar TNF- lesi kulit di ukur dengan metode ELISA. Kadar TNF- lesi kulit ditentukan dengan menghitung nilai rerata pada masing-masing derajat keparahan. Data diolah dengan program SPSS versi 14, hubungan antara kadar TNF- lesi kulit dengan derajat keparahan penyakit diuji dengan menggunakan rumus uji korelasi Spearman. Hasil: Didapatkan rerata kadar TNF- lesi kulit 135,00 + 30,04 pada PASI ringan, 229,40 + 38,06 pada PASI sedang, 258,00 + 53,04 pada PASI berat. Rerata skor PASI penderita psoriasis vulgaris pada derajat ringan 8,57 + 0,57, sedang 16,46 + 3,08 dan berat 28,21 + 10,86. Simpulan: Makin tinggi kadar TNF- makin bertambah pula derajat keparahan psoriasis vulgaris. Kata kunci: psoriasis, TNF-, PASI, derajat keparahan.
Clinical Insights and Diagnostic Dilemmas: Two Cases of Livedoid Vasculitis Earlia, Nanda; Budini, Sulamsih Sri; Lestari, Wahyu; Handriani, Risna; Ismida, Fitri Dewi; Pradistha, Aldilla; Dinillah, Teuku Muhammad Muizzy; Vemulen, Dara Avinda; Athira, Athira
Indonesian Journal of Case Reports Vol. 2 No. 1 (2024): June 2024
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/ijcr.v2i1.183

Abstract

Livedoid Vasculitis (LV) is a thrombo-occlusive vasculopathy involving dermal vessels, especially in the lower extremities. Clinical symptoms of LV are chronic, recurrent, scarring, and painful purpuric ulcers. Diagnosing and providing therapy for LV is a challenge because there are no standard guidelines. We present clinical insights and diagnostic approaches on two cases of LV to improve early diagnosis and prevent misdiagnosis, which were confirmed based on history, dermatological examination, and skin biopsy. In the first case, it was a woman, 23 years old, who came with complaints of a blackish-red rash appearing on both legs. There were scars on several parts of the patient's legs, which felt painful, and the legs looked swollen. On histopathological examination, fibrin deposition in the vessel walls, endothelial proliferation, and intraluminal hyaline thrombin were found. In the second case, it was a man, 19 years old, who came with complaints of pain when walking accompanied by wounds on both lower legs. On histopathological examination, fibrin deposition in the vessel walls, endothelial proliferation, and intraluminal hyaline thrombin were found. The conclusion from the histopathology results was LV. After receiving therapy, both cases showed improvement: swelling in the legs was reduced, red and black rashes began to disappear, ulcers improved, pain decreased, and scars became blurred. These two cases provide examples of success in diagnosing LV. Being able to diagnose LV early and correctly is very important so that adequate therapy can be given and good outcomes can be achieved.
Co-Authors Athira, Athira AUNUR ROFIQ Dinillah, Teuku Muhammad Muizzy Earlia, Nanda Handriani, Risna Ismida, Fitri Dewi M. Cholis Cholis, M. Cholis Pradistha, Aldilla Vemulen, Dara Avinda Wahyu Lestari