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All Journal Majalah Kedokteran Andalas Majalah Patologi Indonesia

Ria Kodariah Ria Kodariah

Departmen of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia

Author-ID : 564796

Health Professions Medicine & Pharmacology Public Health

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Peran CD44 pada Progresivitas Non Alcoholic Steatohepatitis (NASH) Sarwanti; Marini Stephanie; Ria Kodariah
Majalah Patologi Indonesia Vol 29 No 2 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Non alcoholic Steatohepatitis (NASH) is part of a group of conditions called Non-Alcoholic Fatty Liver Diseases(NAFLD) where it is a chronic disease, which defined after elimination other causes of fatty liver, such as excessivealcohol consumption and other causes of chronic liver diseases. NASH is fatty liver disease which characterized byballooning of hepatocyte and lobular inflammation with or without fibrosis. Histopathology diagnose on NASH can bedefined by performing liver biopsy. The purpose of liver biopsy is to define level and degree of the disease. Cluster ofDifferentiation (CD) 44 is a transmembrane glycoprotein receptor which located on the surface of macrophage cells,lymphocytes and endothelial cells. In studies which conducted on mice and humans, showed that CD44 playsimportant role in the progression of NASH. CD44 regulates inflammation of adipose tissue and liver. CD44 ispresumed as a marker which increase macrophage infiltration and other inflammatory cells on liver. This processleads to ultimate increment on insulin resistance and fatty liver. Deficiency was discovered on mice which injectedwith methionine and choline deficiency diet (MCDD). CD44 is associated with preventive method to prevent livercomplication by reducing macrophage or monocyte and as well as neutrophil accumulation in liver which wasevaluated through reducing numbers of inflammatory focus, expression of inflammatory cytokines: tumor necrosisfactor α (TNFα), interleukin (IL) -1B and nitric oxide synthesis (iNOS), and pro-inflammatory types of macrophage. Inobese patients, number of CD44 is predicted to be increasing.

Ekspresi Programmed Death Ligand-1 (PD-L1) pada Seminoma Testis sebagai Potensi Faktor Prognostik Freciyana Boedijono; Budiana Tanurahardja; Ria Kodariah
Majalah Patologi Indonesia Vol 29 No 3 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

BackgroundThe prognosis of testicular seminoma cases which failed to be cured with conventional therapy is poor. Several recurrent eventsafter chemotherapy were also found. PD-L1 is expressed in various types of malignancy and tumor infiltrating lymphocytes (TILs)and its role is known as a prognostic factor. This study was conducted to determine the role of PD-L1 expression seminoma indetermining overall survival (OS) and progression free survival (PFS).MethodsThis is a retrospective cohort study with survival analysis. Clinical data were obtained from medical record in RSUPN CiptoMangunkusumo since January 2011-December 2016 and observed for 2 years. Histopathological data were obtained fromAnatomical Pathology Department and PD-L1 immunohistochemical staining were performed.ResultsA significant correlation between PD-L1 expression in tumor cells with 2-year OS (p=0.023) and PFS (p=0.002) in testicularseminoma was found. No significant correlation between PD-L1 expression in TILs with 2-year OS (p=0.235) and PFS (p=0.111).We also found significant correlations between PD-L1 expression of tumor cells and TILs with PFS (p=0.019). A significantcorrelation between stage with 2-year OS (p=0.010) and PFS (p=0.000) and lymph node metastases with 2-year OS (p=0.010) andPFS (p=0.000).ConclusionPD-L1 expression of testicular seminoma cells were significantly correlated with OS and PFS. There were no statistically significantassociations between PD-L1 expression in TILs with OS and PFS.

PENGARUH EKSTRAK METANOL DAUN SIRSAK (Annona muricata Linn.) TERHADAP VIABILITAS GALUR SEL KANKER PROSTAT Retno Yulianti; Ria Kodariah; Puspita Ekawuyung
Majalah Kedokteran Andalas Vol 37, No 3 (2014): Published in December 2014
Publisher : Faculty of Medicine, Universitas Andalas

AbstrakDaun sirsak mengandung senyawa aktif annonaceous acetogenins yang memiliki efek sitotoksik pada sel kanker. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak daun sirsak terhadap viabilitas dan peningkatan daya hambat terhadap galur sel kanker prostat PC3. Desain penelitian adalah eksperimental in vitro. Subyek penelitian adalah cell line PC3 yang terbagi 5 kelompok yaitu kelompok kontrol sel, kelompok perlakuan dengan ekstrak metanol daun sirsak (EMDS) dengan konsentrasi 6,25; 12,5 dan 25 mg/mL dan kelompok doksorubisin. Kelompok perlakuan diuji viabilitas sel dengan MTT assay pada inkubasi 0 dan 24 jam dan dilakukan pengamatan morfologi sel. Data dianalisis dengan uji statistik ANOVA. Hasil penelitian menunjukkan penurunan nilai OD pada kelompok EMDS 6,25 dan 12,5 ug/mL, namun uji statistik tidak berbeda bermakna dan kemampuan menghambat viabilitas sel paling besar ada pada kelompok EMDS 12,5 ug/mL (nilai OD 0,94). Pengamatan morfologi sel menunjukkan efek sitotoksik. Kesimpulan: Ekstrak metanol daun sirsak memiliki peran potensial sebagai antikanker terhadap galur sel kanker prostat PC3 meskipun sangat kecil efek penghambatannya.AbstractSoursop leaves contain annonaceous acetogenins active compounds that have a cytotoxic effect on cancer cells. The aim of this study is to determine the effect of soursop leaf extract on the viability and inhibitory rate on the prostate cancer cell line PC3. The study was an experimental in vitro study. Subjects were 5 groups of PC3 cell line: cell control group, the group treated with methanol extract of soursop leaves (EMDS) with the concentrations of 6.25; 12.5 and 25 mg/mL and the doxorubicin group. The groups were tested using the MTT cell viability assay at 0 and 24 hours of incubation followed by PC3 cell morphology examination. Data were analyzed by ANOVA test. The results showed a decrease in the OD value of 6.25 and 12.5 ug/mL EMDS group, but statistical tests did not differ significantly and the EMDS 12.5 mg/mL group showed the highest ability in inhibiting cell viability (OD 0.94). Observation of cell morphology showed cytotoxic effects. Conclusion: The methanol extract of soursop leaf has a potential as an anticancer against prostate cancer cell lines despite the very small inhibitory effect.

ANALYSIS OF H3K27ME3 EXPRESSION IN MALIGNANT PERIPHERAL NERVE SHEATH TUMOR (MPNST) AND OTHER SPINDLE CELL SARCOMA MIMICKING MPNST William Yordana; Evelina Evelina; Ria Kodariah
Majalah Patologi Indonesia Vol. 32 No. 3 (2023): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v32i3.585

Malignant Peripheral Nerve Sheath Tumor (MPNST) is a type of spindle cell sarcoma with approximately 5% of all sarcomas. Its diagnosis is challenging due to the absence of specific immunohistochemical markers. Recently, H3K27me3 was discovered as a potential specific immunohistochemical marker to differentiate MPNST from other sarcomas and distinguish between low and high-grade MPNST. Therefore, this research aims to investigate the use of the H3K27me3 as a potential specific marker for Malignant Peripheral Nerve Sheath Tumor (MPNST). A cross-sectional analysis was conducted on 50 cases of sarcomas, including 13 MPNST, 14 synovial sarcomas, 13 dermatofibrosarcoma protuberans (DFSP), and 10 leiomyosarcomas originating from the Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital (FMUI-CMH) from January 2013 to December 2021. H3K27me3 images were obtained and categorized as complete loss when more than 95% of the tumor cells showed loss of nuclear staining. The results found in MPNST showed a loss of H3K27me3 expression, which is statistically significant compared to other sarcomas mimicking MPNST (p=0.021), indicating its potential as a diagnostic marker. There is a difference in the expression of H3K27me3 between the high and low-grade MPNST but it is not statistically significant (p=0.105). This showed that H3K27me3 loss of expression can be used to diagnose MPNST, especially high-grade MPNST, and differentiate it from other sarcomas mimicking MPNST.

Co-Authors Budiana Tanurahardja Evelina Evelina Freciyana Boedijono Marini Stephanie Puspita Ekawuyung Retno Yulianti Sarwanti William Yordana

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