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All Journal Journal of Biomedicine and Translational Research
Endang Mahati
Departement of Pharmacology and Therapy, Faculty of Medicine, Universitas Diponegoro
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Hepatogomax Improves Serum Albumin and Transaminase Enzyme Activity Levels in Sprague Dawley Rats Liver Cirrhosis Refani Alycia Kusuma; Etika Ratna Noer; Hery Djagat Purnomo; Adriyan Pramono; Endang Mahati; Choirun Nissa
Journal of Biomedicine and Translational Research Vol 8, No 3 (2022): December 2022
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v8i3.15078

Abstract

ABSTRACTBackground: Patients with liver cirrhosis had liver cell damage and malnutrition risk. Hepatogomax enteral formula consists of soybean flour and goat’s milk flour which could reduce serum albumin, AST, and ALT levels because it contains BCAA amino acids (valine, leucine, and isoleucine) and MCT.Objective: To examine the effect of Hepatogomax enteral formula based on Soybean flour and goat’s milk flour on serum albumin, AST, and ALT levels in Sprague Dawley rats liver cirrhosis.Methods: The true experimental study – pre-post control group used 24 adult Sprague Dawley rats in 4 groups. Groups K(+), P1, and P2 were induced by Thioacetamide 400 mg/kgBW. The groups of  P1 and P2 were given the Hepatogomax enteral formula made from soybean flour and goat’s milk flour at a dose of 4.87 g/200gBW and 14.6 g/200gBW for 28 days. Serum albumin levels were determined using the Bromocresol Green (BCG) method while serum AST and ALT were determined using spectrophotometry. Statistical analysis had used Paired T-Test and Kruskal Wallis test with Mann Whitney follow-up test.Results: Serum albumin, AST, and ALT levels in the P1 and P2 groups had significant differences (p<0.05) against the K(-) and K(+) groups. Enteral formula based on soybean flour and goat’s milk flour could increase serum albumin levels and reduce serum AST and ALT levels of P1 and P2 groups. The most significant improvement in serum albumin, AST, and ALT levels was at dose 14.6 g/200gBW.Conclusion: Hepatogomax enteral formula based on Soybean flour and goat’s milk flour could increase serum albumin and redue AST, and ALT levels Sprague Dawley rats liver cirrhosis.
The Effect of Liprotide-Encapsulated Vitamin D3 on MDA and SOD in Rats Deficient Vitamin D and Calcium Untari Untari; Gemala Anjani; Faizah Fulyani; Adriyan Pramono; Endang Mahati; Sylvia Rahmi Putri; Reza Achmad Maulana
Journal of Biomedicine and Translational Research Vol 9, No 1 (2023): April 2023
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v9i1.16289

Abstract

Background: Vitamin D deficiency is frequently correlated with elevated malondialdehyde (MDA) levels and decreased superoxide dismutase (SOD) activity. Several studies have demonstrated that vitamin D3 can reverse intracellular oxidative stress. However, vitamin D is prone to deterioration and instability. Liprotides contain lipids and proteins that can prevent vitamin D from oxidating.Objective: This study aims to investigate the effects of liprotide-encapsulated vitamin D3 on MDA concentrations and SOD activity in calcium and vitamin D-deficient rat models.Methods: The experimental post-test-only control group study used 24 Wistar rats randomly in 4 groups. Groups K(-), K(+), and P were fed a vitamin D and calcium-depleted AIN-93M diet for 14 days. Standard feed AIN-93M was received by normal groups (KN). Groups K- were deficient rats in vitamin D and calcium without intervention. The groups of  K+ and P were given vitamin D3 (180 IU) which was non-encapsulated and liprotide-encapsulated for 28 days.The SOD activity was quantified with Superoxide Dismutase (SOD) Activity Assay Kit, while MDA levels were determined using Thiobarbituric Acid Reactive Substance (TBARS) method. The statistical analysis used One-way ANOVA test with Least Significant Difference follow-up test.Results: The MDA levels and SOD activity in the K+ and P groups had significant differences (p<0.05) against the control group. Liprotides-encapsulated vitamin D3 significantly reduced MDA levels and enhanced SOD activity compared to non-encapsulated in rats with a deficiency in vitamin D and calcium.Conclusion: Liprotide-encapsulated vitamin D3 has the potential to increase SOD activity and decrease MDA levels. 
Co-Authors Adriyan Pramono Adriyan Pramono Anjani, Gemala Choirun Nissa Etika Ratna Noer Faizah Fulyani Hery Djagat Purnomo Refani Alycia Kusuma Reza Achmad Maulana Sylvia Rahmi Putri Untari Untari