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Efata B.I. Polii, Efata B.I.
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Gambaran kadar bilirubin pasien tuberkulosis paru selama pengobatan di RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2012 – Desember 2014 Pontoh, Livinia G.; Polii, Efata B.I.; Gosal, Fandy
e-CliniC Vol 4, No 1 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v4i1.10834

Abstract

Abstract: Indonesia still ranks as the third country in the world to have the most cases of tuberculosis (TB). For this reason, there is a needed treatment for TB, called the Anti-Tuberculosis Drugs (ATD) which comprises of isoniazid, ethambutol, pyrazinamide, rifampicin and streptomycin and this should be taken for 6-8 months. However, ATD has side effects mainly in disturbing the liver function that can be assessed by the serum levels checkup of SGOT, SGPT and bilirubin. This study aimed to determine the level of bilirubin pulmonary TB of patients during the treatment in RSUP Prof. DR. R.D. Kandou Manado for the period of January 2012 to December 2014. This was an observational descriptive study with a cross sectional design by using the medical records of patients of pulmonary TB hospitalization for the period of January 2012 to December 2014. There were 32 patients as samples. There has been an increase in total bilirubin levels during the ATD treatment. It has been discovered that as big as (47%) had an increase level of total bilirubin. The total of bilirubin levels had increased more in male patients. The increase in the total bilirubin occurred in the age of >35 and the more it increases with age. Meanwhile, the increase in direct bilirubin levels had been found in as many as (56%). The indirect bilirubin levels had been found to be normal in (91%). A total of (31%), with hyperbilirubinemia, had not had comorbidities and most had often occurred in the first month of ATD treatment.Keywords: pulmonary tuberculosis, bilirubin, antituberculosis drug, hepatotoxicityAbstrak: Indonesia masih menempati urutan ketiga negara penderita tuberkulosis (TB) terbanyak didunia. Untuk itulah, dibutuhkan pengobatan TB, yang dinamakan Obat Anti Tuberkulosis (OAT) yang terdiri isoniazid, etambutol, pirazinamid, rifampicin dan streptomisin yang harus dikonsumsi selama 6-8 bulan. Akan tetapi, OAT memiliki efek samping terutama menggangu fungsi hati yang dapat dinilai melalui pemeriksaan kadar serum SGOT, SGPT dan bilirubin. Untuk mengetahui kadar bilirubin pasien TB Paru selama pengobatan di RSUP Prof DR. R.D. Kandou Manado periode Januari 2012-Desember 2014. Desain penelitian yang digunakan adalah penelitian observasional deskriptif dengan pendekatan potong lintang (cross sectional) dengan memanfaatkan rekam medik pasien TB Paru rawat inap periode Januari 2012-Desember 2014. Jumlah sampel yang terpakai sebanyak 32 orang. Terjadi peningkatan kadar bilirubin total selama pengobatan OAT. Ditemukan sebesar (47%) terjadi peningkatan kadar bilirubin total. Kadar bilirubin total meningkat lebih banyak pada pasien laki-laki. Peningkatan bilirubin total terjadi pada usia >35 tahun dan semakin meningkat seiring bertambahnya usia. Sedangkan, kadar bilirubin direk ditemukan sebanyak (56%) terjadi peningkatan kadar bilirubin direk. Kadar bilirubin indirek ditemukan normal pada (91%). Sebanyak (31%) yang menderita hiperbilirubinemia tidak memiliki penyakit penyerta dan paling sering terjadi pada satu bulan pertama pengobatan OAT.Kata kunci: tuberkulosis paru, bilirubin, obat antituberkulosis, hepatotoksitas
Hubungan Kadar Hematokrit dan Tekanan Darah pada Subjek Laki-laki Perokok Usia Dewasa Muda Isa, Roi O.; Rotty, Linda W.A.; Polii, Efata B.I.
e-CliniC Vol 5, No 2 (2017): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v5i2.18571

Abstract

Abstract: Smoking is a major health problem in Indonesia especially in adult males. The age of a person to initially start smoking becomes younger, therefore, the prevalence of smoking in Indonesia has increased in 2013 (36.3%) compared to that in 2007 (34.2%). Smoking is a risk factor for a number of chronic diseases such as cancer, lung diseases, and cardiovascular diseases. Several previous studies had suggested a relationship between hematocrit levels, blood viscosity and blood pressure. This study was aimed to determine the correlation between hematocrit level and blood pressure in young adult male smokers as subjects. This was an analytical study with a cross-sectional design. Blood pressure and hematocrit level were performed on a total of 40 male students of the Faculty of Engineering Sam Ratulangi University Manado. Data were analyzed statistically by using the Spearman correlation test. The correlation test on the relationship between blood hematocrit level and systolic blood pressure showed an r value of 0.236 and a P value of 0.143 while the correlation test on the relationship between blood hematocrit level and diastolic blood pressure resulted in an r value of 0.352 and a P value of 0.026. Conclusion: There was a positive correlation between hematocrit level and diastolic blood pressure in young adult smokers but not for systolic blood pressure.Keywords: smokers, hematocrit, blood pressure Abstrak: Merokok menjadi masalah kesehatan utama di Indonesia khususnya pada kaum lelaki dewasa. Usia seseorang mulai merokok semakin muda dan prevalensi merokok di Indonesia mengalami peningkatan pada tahun 2013 (36,3%) dibandingkan tahun 2007 (34,2%). Merokok sebagai faktor risiko sejumlah penyakit kronis seperti kanker, penyakit paru-paru, dan penyakit kardiovaskuler. Beberapa penelitian sebelumnya menyatakan adanya hubungan antara kadar hematokrit, viskositas darah, dan tekanan darah. Penelitian ini bertujuan untuk mengetahui hubungan kadar hematokrit dan tekanan darah pada subjek laki-laki perokok usia dewasa muda. Jenis penelitian ialah analitik dengan desain potong lintang. Subyek penelitian ialah 40 orang mahasiswa laki-laki Fakultas Teknik Universitas Sam Ratulangi Manado. Pemeriksaan tekanan darah dan hematokrit darah dilakukan terhadap seluruh subyek. Analisis statistik menggunakan uji korelasi Spearman. Hasil uji korelasi pada hubungan kadar hematokrit dengan tekanan darah sistolik (TDS) mendapatkan nilai r=0,236 dan nilai P =0,143 sedangkan pada hubungan kadar hematokrit dengan tekanan darah diastolik (TDD) didapatkan nilai r=0,352 dan nilai P=0,026. Simpulan: Terdapat hubungan positif antara kadar hematokrit dan tekanan darah diastolik pada perokok laki-laki usia dewasa muda tetapi tidak berlaku untuk tekanan darah sistolik.Kata kunci: perokok, hematokrit, tekanan darah
Profil pasien tuberkulosis dengan multi drug resistance (MDR) di RSUP Prof. Dr. R. D. Kandou periode Agustus 2015 - Agustus 2016 Siahaan, Andreas G.H.; Polii, Efata B.I.; Ongkowijaya, Jeffrey
e-CliniC Vol 4, No 2 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v4i2.14498

Abstract

Abstract: Multidrug Resistance Tuberculosis (MDR-TB) is a serious health problem in society towards the effort to eliminate TB and its prevention in global scale as well as in Indonesia. MDR-TB incidence is difficult to determine because sputum propagation and medicine sensitivity test is not routinely implemented in places with high prevalence. The raising of TB MDR is influenced by several factors, as follows: the patients, caregivers, and medical service factors. This study was aimed to determine the profile of TB-MDR patients treated at Prof. Dr. R. D. Kandou Hospital Manado from August 2015 to August 2016. This was a descriptive-retrospective study based on secondary data of the medical record in period August 2015 - August 2016 at Prof. Dr. R. D. Kandou Hospital Manado. The results showed that of 30 patients who met the inclusion criteria, the highest percentages were in males (67%), age range 41-50 years (36%), senior high school as the latest education (54%), patients originated from Manado (63.33%), normal nutrition status (57%), and the GeneXpert result was medium (56%). The most common comorbidity was type 2 DM (23%). Conclusion: In this study, the majority of MDR-TB patients were males, age range 41-50 years, senior high school as the last education was SLTA, originated from Manado, normal nutrition status, and the GeneXpert resulted in medium. Morbidities of most patients experienced is DM type 2.Keywords: TB, TB MDR, genexpert Abstrak: Multidrug resistance tuberculosis (TB MDR) memrupakan masalah kesehatan yang serius di dalam masyarakat terhadap pemberantasan TB serta pencegahannya baik dalam skala dunia maupun di Indonesia. Kejadian TB MDR sulit ditentukan karena biakan sputum dan uji kepekaan obat tidak rutin dilaksanakan di tempat-tempat dengan prevalensi tinggi. Peningkatan TB MDR dipengaruhi oleh beberapa faktor seperti faktor pasien, pemberi pelayanan, dan sistem pelayanan kesehatan. Penelitian ini bertujuan untuk mengetahui profil pasien TB MDR yang berobat di RSUP Prof. Dr. R.D. Kandou Manado periode Agustus 2015 – Agustus 2016. Jenis penelitian ialah deskriptif-retrospektif berdasarkan data sekunder dari catatan rekam medik pada periode Agustus 2015-Agustus 2016 di RSUP Prof. Dr. R. D. Kandou Manado. Hasil penelitian memperlihatkan dari 30 data rekam medik pasien yang memenuhi kriteria inklusi, ditemukan lebih banyak pasien berjenis kelamin laki-laki (67%), rentang usia 41-50 tahun (36%), berpendidikan terakhir SLTA (54%), asal daerah Manado (63,33%), gizi normal (57%), dan hasil GeneXpert medium (56%). Penyakit penyerta terbanyak ialah DM tipe 2 (23%) Simpulan: Pada studi ini didapatkan pasien TB MDR terbanyak berjenis kelamin laki-laki, dengan rentang usia pasien 41-50, pendidikan terakhir SLTA, dan asal daerah Manado. Pasien terbanyak memiliki gizi normal dan hasil GeneXpert medium dengan penyakit penyerta DM tipe 2. Kata kunci: TB, TB MDR, genexpert