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All Journal PHARMACON Pharmascience Hydrogen: Jurnal Kependidikan Kimia Room of Civil Society Development
Hasnaeni hasnaeni, Hasnaeni
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Arts Humanities Chemistry Education Medicine & Pharmacology Social Sciences Other

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Journal : Hydrogen: Jurnal Kependidikan Kimia

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Cytotoxic Activity of Gude Leaves (Cajanus cajan) using The Brine Shrimp Lethality Test (BSLT) Method Emelda, Andi; Hasnaeni, Hasnaeni; Ulfa, Amanda
Hydrogen: Jurnal Kependidikan Kimia Vol 12, No 2 (2024): April-May 2024
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v12i2.11077

Abstract

Gude Leaves (Cajanus cajan) are a traditional medicinal plant for treating diarrhea. The ingredients contained in Gude leaves are flavonoids, such as kajanol, quarcetin and luteolin and also contain other secondary metabolites, tannins, saponins, alkaloids, terpenoids and phenols. Scientifically, Gude leaves have antimalarial, antidiabetic, anthelmintic, antioxidant, antibacterial and anticancer activity. This research aims to determine the toxicity of gude leaves (C. cajan) using the Brine Shrimp Lethality Test (BSLT) method. This research began by carrying out two extraction methods, namely maceration and UAE (Ultrasonic Assisted Extraction) on samples of gude leaves using 70% ethanol solvent. Then a phytochemical screening was carried out which showed that samples of gude leaves contained alkaloids, flavonoids, steroids, saponins and tannins. Experimentation the toxicity of gude leaf extract using maceration and UAE methods on Artemia Salina Leach larvae, each divided into 5 test groups, namely 4 treatment groups (concentrations of (250 ppm,  LC=23,33% & 33,33%) ; (500 ppm, LC= 56,67% & 60%); (750 ppm, LC= 70% & 73%); and (1000 ppm, LC= 80%) and 1 positive control group (sea water ). The research results can be seen through probit analysis by calculating the LC50 value. The LC50 value of gude leaf extract using the maceration method was 242.52 and the result of gude leaf extract using the UAE method was 394.16 (Toxic).  This research provides information regarding the toxic effects of gude leaf extract.
Identification of Medicinal Chemicals (BKO) Piroxicam in Jamu Pegal Linu Preparations in Makassar City Hasnaeni, Hasnaeni; Handayani, Selpida; Andina, Velda
Hydrogen: Jurnal Kependidikan Kimia Vol 12, No 1 (2024): February 2024
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v12i1.10576

Abstract

The aim of the research was to identify Piroxicam in herbal medicine for rheumatic pain circulating in Makassar. There are several traditional medicines that contain medicinal chemicals. Research has been conducted on the identification of medicinal chemicals (BKO) on several rheumatic herbs preparations in herbs shops in Makassar. The BKO which is often included in rheumatic herbs is the NSAID group, one of which is piroxicam. This inspection was conducted to know the presence of the chemical drug piroxicam contained within rheumatic herbs preparations and the samples used were 5 samples. The method used was a qualitative test using thin layer chromatography (TLC) consisting of a mobile phase mixed with n-hexane and acetone (7:3) and a stationary phase using Silica Gel GF254. The results of the TLC examination from 5 samples of herbal medicine added BKO piroxicam contained 3 samples including herbs A, B, and C because they had the same stain color at the same Rf value as the piroxicam. Some of the rheumatic herbs circulating in Makassar contain medicinal chemicals in the form of piroxicam.
Co-Authors A, Alfiah Andi Emelda Andina, Velda Erna Kadrianti Firawati Firawati Indah Pratiwi Kasim, Jamila Selpida Handayani, Selpida Ulfa, Amanda