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All Journal Jurnal Pendidikan Matematika dan IPA Biosaintifika: Journal of Biology & Biology Education
Titrawani Titrawani, Titrawani
Jurusan Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Riau
Agriculture, Biological Sciences & Forestry Chemistry Education Mathematics Physics

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Histological Study of White Rats Kidney Following The Consumption of Obat Pahit From Riau Archipelago Fitmawati, Fitmawati; Saputra, Agus; Titrawani, Titrawani; Juliantari, Erwina; Kusumo, Awal Prichatin
Biosaintifika: Journal of Biology & Biology Education Vol 11, No 2 (2019): August 2019
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (619.812 KB) | DOI: 10.15294/biosaintifika.v11i2.15065

Abstract

Obat Pahit from Lingga Malay ethnic is a traditional medicine which has believed by the local people to maintain the body stamina (immunomodulators and antioxidants). This study aimed to investigate the effect of Obat Pahit Potion on kidney histological structure of white male rats (Rattus norvegicus). This research was an experimental study with a Randomized Complete Block Design consisted of 15 treatments and 3 replications. The experiment groups consisted of control groups (Stimuno, distilled water, and CMC-Na 1%) and three treatment groups of Obat Pahit Potion (Kalan, SP4, Linau) with 4 different dosages. The samples of a kidney of white rats were prepared for histological observation using paraffin method and Hematoxylin-Eosin staining. The results of this study showed that three kinds of Obat Pahit with four different dosages showed the expansion of glomerular cells on kidney tissue. Damage that occurs in the kidneys is still in small amounts and normal range which is less than 25%. The results of this study provide information for the society that the consumption of Obat Pahit Potion will not cause toxicity effect on the kidney.
EFFECTS OF NATURAL EXTRACT OF CELERY LEAVES ON THE KIDNEYS OF WHITE RATS (Rattus novergicus) AFTER ASPIRIN INDUCTION Indriana, Edni; Titrawani, Titrawani
Jurnal Pendidikan Matematika dan IPA Vol 13, No 2 (2022): July 2022
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (573.668 KB) | DOI: 10.26418/jpmipa.v13i2.54598

Abstract

Herbal plants can be used as a treatment option, including the treatment of kidney disease. The administration of herbal remedies such as celery is a more natural and safe treatment healing alternative. The study aims to determine the effect of celery extract in repairing the damage to the kidney cells of aspirin-induced white mice. This study used a completely randomized design (CRD) consisting of 5 groups with 3 replications: K- (aspirin 12.6 mg/kg BW), K+ (feed normal), P1 (celery extract 200 mg/kg BW + aspirin 12.6 mg/kg BW), P2 (celery extract 100mg/kg BW + aspirin 12.6 mg/kg BW) and P3 (celery extract 50 mg/kg BW) + aspirin 12.6 mg/kg BW). From the results of observations on kidney histology of rats after giving aspirin, it is known that there is damage to the nucleus of cells undergoing pyknosis and swelling of the glomerulus, which is characterized by narrowing of the Bowman's space. This suggests that the celery extract at a stratified dose may affect the histopathological kidney of aspirin-induced mice. 
Co-Authors ERWINA JULIANTARI, ERWINA Fitmawati Fitmawati Indriana, Edni Kusumo, Awal Prichatin Saputra, Agus Welly Safitri, Welly