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All Journal Jurnal Kedokteran Diponegoro
Nani Maharani
Department of Pharmacology, Faculty of Medicine, Universitas Diponegoro, Semarang
Medicine & Pharmacology

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EFFECT OF MELINJO SEED EXTRACT ON URIC ACID LEVELS OF HYPERURICEMIC MALE WISTAR RATS Al Ghiffari Muhammad Rayhan; Nani Maharani; Endang Mahati; Yora Nindita
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 1 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i1.37579

Abstract

Background : Uric acid is the end product of purine catabolism carried out in the liver. Increased level of uric acid in blood is called hyperuricemia, which might cause gout if it is not treated properly. Melinjo (Gnetum gnemon L.) plant is a native plant of Indonesia that contains flavonoids and stilbenoid potential as antihyperuricemia. Aim : This paper aimed to study the effect of melinjo seed extract on uric acid levels. Methods : Thirty-six male wistar rats were randomly divided into 6 groups, consists of healthy control group, hyperuricemic control, Allopurinol control, and treatment groups (3 groups).  Hyperuricemia was induced by the administration of block broth and potassium oxonate for 4 weeks. Melinjo seed extract doses of 250, 500, and 2000 mg/kg BW, and allopurinol 90 mg/kg BW was given orally for 2 weeks. Statistical analysis was conducted to evaluate differences among groups before and after the intervention. Results : Three doses could significantly reduce uric acid levels (p<0.05) from 5.61±0.95 to 2.45±1.21; 5.86±1.84 to 2.04±1.11; and 5.95±0.91 to 3.59±1.58, respectively. However, there is no significant difference between the three doses. The effectiveness of melinjo seed extract at a dose of 500 mg/kg BW reduced uric acid levels by 65%, a dose of 250 mg/kg BW by 56%, and allopurinol 90 mg/kg BW by 10%. Conlusion : Melinjo seed extract can reduce uric acid levels even though there is no effect of graded dose. 
Co-Authors Al Ghiffari Muhammad Rayhan Endang Mahati Yora Nindita