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Yora Nindita
Department of Pharmacology, Faculty of Medicine, Universitas Diponegoro, Semarang
Medicine & Pharmacology

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EFFECT OF MELINJO SEED EXTRACT ON URIC ACID LEVELS OF HYPERURICEMIC MALE WISTAR RATS Al Ghiffari Muhammad Rayhan; Nani Maharani; Endang Mahati; Yora Nindita
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 1 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i1.37579

Abstract

Background : Uric acid is the end product of purine catabolism carried out in the liver. Increased level of uric acid in blood is called hyperuricemia, which might cause gout if it is not treated properly. Melinjo (Gnetum gnemon L.) plant is a native plant of Indonesia that contains flavonoids and stilbenoid potential as antihyperuricemia. Aim : This paper aimed to study the effect of melinjo seed extract on uric acid levels. Methods : Thirty-six male wistar rats were randomly divided into 6 groups, consists of healthy control group, hyperuricemic control, Allopurinol control, and treatment groups (3 groups).  Hyperuricemia was induced by the administration of block broth and potassium oxonate for 4 weeks. Melinjo seed extract doses of 250, 500, and 2000 mg/kg BW, and allopurinol 90 mg/kg BW was given orally for 2 weeks. Statistical analysis was conducted to evaluate differences among groups before and after the intervention. Results : Three doses could significantly reduce uric acid levels (p<0.05) from 5.61±0.95 to 2.45±1.21; 5.86±1.84 to 2.04±1.11; and 5.95±0.91 to 3.59±1.58, respectively. However, there is no significant difference between the three doses. The effectiveness of melinjo seed extract at a dose of 500 mg/kg BW reduced uric acid levels by 65%, a dose of 250 mg/kg BW by 56%, and allopurinol 90 mg/kg BW by 10%. Conlusion : Melinjo seed extract can reduce uric acid levels even though there is no effect of graded dose. 
THE EFFECT OF KAFFIR LIME PEEL EXTRACT (Citrus hystrix) ON SPATIAL MEMORY OF MICE WITH DEMENTIA USING MORRIS WATER MAZE Florentina Anindita Christiyanto; Endang Mahati; Noor Wijayahadi; Yora Nindita
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.37788

Abstract

Background: Antioxidants are a group of chemicals that protect biological systems against the potential harmful effects of oxidation processes or its reactions. Kaffir lime peel (Citrus hystrix) contains various potential antioxidants substances those are able to protect neurons from free radical-induced damage. Objective: To evaluate the effect of kaffir lime peel extract (Citrus hystrix) on the spatial memory of mice induced by Scopolamine (SCM). Methods: This research was a true experimental study with a post-test-only controlled group design. Thirty mice were randomly divided into 5 groups. SCM was injected intraperitoneally on day 1-7 and kaffir lime peel extract was given orally on day 2-7, the spatial memory testing of mice using Morris Water Maze on day 8. Data analysis used One-Way ANOVA test (α = 0.05) and continued with Post Hoc LSD test (α = 0.05). Results: The mean spatial memory of K+, K-, P1, P2,P3 were 16,33 ± 7,42; 70,00 ± 32,24; 25,66 ± 24,43; 23,00 ± 19,39; 25,00 ± 19,50 seconds respectively. There were significant differences in spatial memory in P1, P2, dan P3 to the negative control group, but there is no significant differences between treatment grups. Conclusion: Kaffir lime peel extract (Citrus hystrix) can improve the spatial memory of scopolamine-induced dementia (SCM) mice. There is no dose effect relationship between the treatment groups
EFFECTIVENESS TEST OF 0.2% CHLORHEXIDINE AND HIBISCUS (Hibiscus rosa sinensis L.) EXTRACT AGAINST Streptococcus sp BACTERIA ON DENTAL PLAQUE Athalaila Azzahrasukma Sakuntala; Arlita Leniseptaria Antari; Ira Anggar Kusuma; Yora Nindita
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.36720

Abstract

ABSTRACTBackground: Streptococcus sp colonies are Gram-positive coccus bacteria that play a role in the formation of dental plaque and cause dental caries. However, dental caries can be prevented with the gold standard mouthwash, namely chlorhexidine. In other studies, many mouthwashes have been developed using traditional ingredients that have antibacterial potential, one of which is hibiscus flower (Hibiscus rosa sinensis L.). This is due to the presence of chemical compounds that can inhibit the growth of Streptococcus sp in dental plaque.Objectives: Testing the effectiveness of 0.2% chlorhexidine and H. rosa sinensis L. extract against Streptococcus sp in dental plaque.Method: Laboratory experimental research with pre and post test only control group design on 6 groups. Group K- (aquades), K+ (chlorhexidine), H. rosa sinensis L. extract 6.25% (P1), 12.5% (P2), 25% (P3), 40% (P4). Each of these groups consisted of 4 subjects. Data were obtained by counting the number of Streptococcus sp colonies before and after gargling which had been streak-cultured on blood agar media. The statistical analysis used the Shapiro Wilk test showed significant results P ≥ 0.05, followed by the One Way ANOVA parametric test. While the not significant results with the Kruskall Wallis non-parametric test.Results: There was a significant difference between the 4 concentrations of H. rosa sinensis L. extract 6.25% (P1), 12.5% (P2), 25% (P3), and 40% (P4) with the control (+) (p = 0 .00), and at a concentration of 25% (P3) effectively inhibited the growth of Streptococcus sp bacteria by 12.5%.Conclusion: H. rosa sinensis L. extract was effective compared to 0.2% chlorhexidine in inhibiting the growth of Streptococcus sp. Administration of various concentrations of H. rosa sinensis L. mouthwash extract inhibited the growth of Streptococcus sp, and at a concentration of 25% (P3) effectively inhibited Streptococcus sp by 12.5%.
Effect of Melinjo Seed Extract on GSH Levels of Hyperuricemic Wistar Rats Ardhana Fadhiilah; Endang Mahati; Noor Wijayahadi; Yora Nindita
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 3 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i3.37507

Abstract

Background: Hyperuricemia is a condition where uric acid levels are above normal. The biosynthesis of uric acid by the enzyme xanthine oxidase (XO) produces free radicals that cause oxidative stress. Oxidative stress lowers cellular GSH levels. Gnetum gnemon L. or melinjo seeds contain stilbenoids and flavonoids that can act as natural XO inhibitors. Objective: To study the effect of melinjo seed extract on GSH levels.Methods: This research was a true experimental with pre and post-test controlled group design. Thirty six male wistar rats were randomly divided into 6 groups consisting of a healthy control (KS), negative control (K1), positive control (K2), treatment 1 (P1) extract 250 mg/kgBW, treatment 2 (P2) extract 500 mg/kgBW, treatment 3 (P3) extract 2000 mg/kgBW. Hyperuricemia was induced by the administration of Maggie® block broth and potassium oxonate. Measurement was carried out on the 21st and 35th day of treatment, then analyzed using Paired-Sample T Test, continued with One-Way Anova test and Post Hoc LSD test. Results: Administration of melinjo seed extract at P1, P2, and P3 significantly increased GSH levels (P<0.05) from 1.23±0.10 to 1.55±0.16; 1.22±0.06 to 1.73±0.16; and 1.21±0.08 to 1.88±0.08. There was significant difference between the three doses with a dose of 250 mg/kgBW melinjo seed extract being more effective than allopurinol 90 mg/kgBW. Conclusion: Melinjo seed extract could increase GSH levels with the most effective dose of 250 mg/kgBB.
Co-Authors Al Ghiffari Muhammad Rayhan Ardhana Fadhiilah Arlita Leniseptaria Antari Athalaila Azzahrasukma Sakuntala Endang Mahati Florentina Anindita Christiyanto Ira Anggar Kusuma Nani Maharani Noor Wijayahadi