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All Journal Journal of Anaesthesia and Pain
Mayasari Mayasari
Anesthesiology and Intensive Therapy, Faculty of Medicine, Brawijaya University/ Dr. Saiful Anwar General Hospital , Malang
Health Professions Medicine & Pharmacology

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Continuous Ketamine Administration Decreases Monocyte Count in Sepsis Patients in Intensive Care Units Ruddi Hartono; Wiwi Jaya; Mayasari Mayasari; Isngadi Isngadi
Journal of Anaesthesia and Pain Vol 4, No 1 (2023): January
Publisher : Faculty of Medicine, Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jap.2023.004.01.01

Abstract

Background: Cytokines storm becomes the most common cause of mortality in sepsis patients treated in the intensive care unit (ICU). Cytokines storm is characterized by an excessive elevation in the immunocompetent cells, including monocyte. Ketamine, as a sedating agent, has immunosuppressive properties. This study was conducted to determine the effect of ketamine on monocyte count in septic patients in the ICU.Methods: This is a quantitative case-controlĀ  study of 30 patients treated in the ICU. The study subjects were divided into control (n=15) and treatment (n=15) groups. The treatment group received ketamine HCl therapy at 0.3 mg/kg body weight/hour. The mean monocytes were counted at 0, 24, and 48 hours post-therapy. Data analysis used an independent sample t-test with Ī±=5%.Result: Administration of ketamine therapy in septic patients treated in the ICU showed a decrease in the monocytes during observation from 0 to 48 hours post-therapy. Administration of ketamine at 48 hours had a significantly lower monocyte (5.21%) compared to control (7.67%) (p=0.012).Conclusion: Ketamine administration reduces the monocytes count in septic patients treated in the intensive care unit. Ketamine is expected to be a therapeutic option in sepsis patients.
Co-Authors Isngadi Isngadi Ruddi Hartono Wiwi Jaya