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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Taufik Indrajaya
Division of Cardiovascular, Department of Internal Medicine, Faculty of Medicine, Universitas Sriwijaya/Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

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The Relationship between Neutrophil Lymphocyte Ratio and Hepatitis C Virus RNA in Hepatitis C Coinfected HIV Patients Receiving Direct-Acting Antiviral Therapy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Suyata; Prabjot Singh; Harun Hudari; Taufik Indrajaya; Nurmalia Purnama Sari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.761

Abstract

Background: Hepatitis C is an inflammatory disease of the liver caused by infection with the hepatitis C virus (HCV). Inflammatory markers are significant in assessing the course of an infectious or inflammatory disease. One of them is the neutrophil-lymphocyte ratio (NLR) and the amount of HCV RNA viral load, which combines neutrophils as an active inflammatory component and lymphocytes as a regulatory and protective component in a single parameter. Research on the relationship between NLR and HCV RNA in HIV patients coinfected with HCV is still limited. This study aimed to determine the relationship between NLR and HCV RNA in HIV-HCV coinfected patients who received DAA therapy and went to the outpatient polyclinic at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: Analytic observational study. A total of 38 research subjects participated in this study. Observation of NLR was carried out using hematology analyzer, and observation of HCV RNA levels was carried out using the PCR technique. Data analysis was carried out using SPSS univariate and bivariate. Results: There was a difference between pre-post therapy NLR and pre-post therapy HCV RNA viral load, p<0.05. NLR is in line with HCV RNA viral load as a prognostic tool for successful DAA therapy in HIV patients coinfected with hepatitis C. Conclusion: There is a relationship between HIV and HCV RNA in hepatitis C coinfected HIV patients receiving direct-acting antiviral therapy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.
The Relationship between Neutrophil Lymphocyte Ratio and Hepatitis C Virus RNA in Hepatitis C Coinfected HIV Patients Receiving Direct-Acting Antiviral Therapy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Suyata; Prabjot Singh; Harun Hudari; Taufik Indrajaya; Nurmalia Purnama Sari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.761

Abstract

Background: Hepatitis C is an inflammatory disease of the liver caused by infection with the hepatitis C virus (HCV). Inflammatory markers are significant in assessing the course of an infectious or inflammatory disease. One of them is the neutrophil-lymphocyte ratio (NLR) and the amount of HCV RNA viral load, which combines neutrophils as an active inflammatory component and lymphocytes as a regulatory and protective component in a single parameter. Research on the relationship between NLR and HCV RNA in HIV patients coinfected with HCV is still limited. This study aimed to determine the relationship between NLR and HCV RNA in HIV-HCV coinfected patients who received DAA therapy and went to the outpatient polyclinic at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia. Methods: Analytic observational study. A total of 38 research subjects participated in this study. Observation of NLR was carried out using hematology analyzer, and observation of HCV RNA levels was carried out using the PCR technique. Data analysis was carried out using SPSS univariate and bivariate. Results: There was a difference between pre-post therapy NLR and pre-post therapy HCV RNA viral load, p<0.05. NLR is in line with HCV RNA viral load as a prognostic tool for successful DAA therapy in HIV patients coinfected with hepatitis C. Conclusion: There is a relationship between HIV and HCV RNA in hepatitis C coinfected HIV patients receiving direct-acting antiviral therapy at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.
The Relationship between Skeletal Muscle Strength and Cardiac Senescence Performance in the Elderly at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Muhammad Haryadi Ade Kurnadi; Nur Riviati; Taufik Indrajaya; Mgs. Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 10 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i10.873

Abstract

Background: The aging process is physiological, but the onset, rate, and extent of the progression of aging at the cell, tissue, organ, and system level are very heterogeneous because they are influenced by genetic and environmental factors. The aging process is known to involve the entire body, including musculoskeletal and cardiovascular components. Several theories explain this association, including reduced muscle mass associated with chronic heart failure, decreased serum myostatin, and cross-talk between skeletal and cardiac muscle mediated by inflammatory cytokines. This study aimed to determine the relationship between skeletal muscle strength and cardiac performance in elderly patients at Dr. Mohammad Hoesin General Hospital, Palembang. Methods: This research is an analytical observational study with a cross-sectional design. The total sample size was 65 individuals who met the inclusion and exclusion criteria. Data analysis was carried out using the SPSS 25 for Windows program. Results: Handgrip strength has a significant relationship with diastolic dysfunction on a numerical scale (p=0.009). Low handgrip strength has a 3 times greater risk of experiencing diastolic dysfunction than patients with Normal Handgrip Strength. Conclusion: Skeletal muscle strength has a relationship with cardiac senescence performance in elderly patients at Dr. Mohammad Hoesin General Hospital, Palembang.
The Relationship between Skeletal Muscle Strength and Cardiac Senescence Performance in the Elderly at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Muhammad Haryadi Ade Kurnadi; Nur Riviati; Taufik Indrajaya; Mgs. Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 10 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i10.873

Abstract

Background: The aging process is physiological, but the onset, rate, and extent of the progression of aging at the cell, tissue, organ, and system level are very heterogeneous because they are influenced by genetic and environmental factors. The aging process is known to involve the entire body, including musculoskeletal and cardiovascular components. Several theories explain this association, including reduced muscle mass associated with chronic heart failure, decreased serum myostatin, and cross-talk between skeletal and cardiac muscle mediated by inflammatory cytokines. This study aimed to determine the relationship between skeletal muscle strength and cardiac performance in elderly patients at Dr. Mohammad Hoesin General Hospital, Palembang. Methods: This research is an analytical observational study with a cross-sectional design. The total sample size was 65 individuals who met the inclusion and exclusion criteria. Data analysis was carried out using the SPSS 25 for Windows program. Results: Handgrip strength has a significant relationship with diastolic dysfunction on a numerical scale (p=0.009). Low handgrip strength has a 3 times greater risk of experiencing diastolic dysfunction than patients with Normal Handgrip Strength. Conclusion: Skeletal muscle strength has a relationship with cardiac senescence performance in elderly patients at Dr. Mohammad Hoesin General Hospital, Palembang.
Co-Authors Harun Hudari Muhammad Haryadi Ade Kurnadi Muhammad Irsan Saleh Nur Riviati Nurmalia Purnama Sari Prabjot Singh Suyata