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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Calvaria Medical Journal
Andiani Andiani
Bagian Ilmu Kesehatan Masyarakat Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya
Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Public Health

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Potency of Ethanol Extract Celery (Apium graveolens L.) Stalk as Anti-Cholesterol I Made Subhawa Harsa; Andiani Andiani; Harsono Wiradinata; Putu Oky Ari Tania
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 2 (2022): EDISI SEPTEMBER 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.864 KB) | DOI: 10.30742/jikw.v11i2.2014

Abstract

Increasing levels of blood cholesterol is one of the risk factors for atherosclerosis. Currently, experts have been trying used herbal medicine as an alternative treatment of atherosclerosis. One of the highlights is the use of celery stalks. Celery is generally used as a flavouring dish. In addition, celery stalks are believed able to reduce cholesterol levels because they contain flavonoids, tannins, and saponins. This study was aim to determine the effect of celery stalk ethanol extract to reduce LDL an increase of HDL level in rats after fed high-fat diet. Randomized Post Test Only Control Group Design was used to measure the HDL and LDL blood serum levels of male Wistar (Rattus norvegicus) rats fed a high-fat diet. This study was used 27 male Wistar rats (Rattus norvegicus) divided into 3 groups; K1 was only given regular feed and water, K2 was given a high-fat diet and water, K3 was given a high-fat diet and celery stalk extract at a dose of 75mg/kg BW/day for 14 days. The data were analysed by ANOVA test and Tukey HSD test. The results of the ANOVA test showed a significance value of p-value of LDL = 0.000 and HDL p-value = 0.536. Celery stalk extract (Apium graviolens L) had an effect on decreasing LDL levels but not on increasing HDL blood serum levels of white Wistar rats (Rattus norvegicus) given high-fat diet.
Hubungan Tingkat Stres dengan Kejadian Nyeri Neuropati Diabetik pada Pasien Dm Tipe 2 Di RS Bhayangkara Watukosek Eka Wahyu Dewangga; Andiani Andiani
Calvaria Medical Journal Vol 1 No 2 (2023): Edisi Desember 2023
Publisher : Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/cmj.v1i2.24

Abstract

Introduction: Therapy for diabetic neuropathy pain has not been able to provide a significant effect for patients so that the side effects of pain complaints affect the quality of work and social life of type 2 DM patients at Bhayangkara Watukosek Hospital. The aim of this study was to determine whether stress levels can influence the incidence of diabetic neuropathy pain at Bhayangkara Watukosek Hospital. Method: The research is analytical in nature with Odds Ratio (OR) calculations to test hypotheses. The research population was 250 type 2 DM patients with a sample of 40 respondents taken at simple random. The variables consist of the incidence of diabetic neuropathy pain as the dependent variable, and stress level as the independent variable. Result: the relationship between stress levels and the incidence of NND in type 2 DM patients at Bhayangkara Watukosek Hospital produced an odds ratio of 3 (OR > 1). Conclusion: respondents who experienced stress were 3 times more likely to experience NND than respondents who were not stressed. To reduce or suppress the incidence of NND, people who suffer from type 2 DM and are aged ≥50 years should have regular check-ups at the hospital to prevent NND. For the management of Bhayangkara Watukosek Hospital, it is recommended to carry out a mentoring program for type 2 DM patients who are ≥50 years old because many respondents who suffer from NND and experience stress are ≥50 years old.
Co-Authors Eka Wahyu Dewangga Harsono Wiradinata I Made Subhawa Harsa Putu Oky Ari Tania