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All Journal Jurnal Kedokteran Diponegoro
Noor Wijayahadi
Department of Pharmacology, Faculty of Medicine, Universitas Diponegoro, Semarang
Medicine & Pharmacology

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THE EFFECT OF KAFFIR LIME PEEL EXTRACT (Citrus hystrix) ON SPATIAL MEMORY OF MICE WITH DEMENTIA USING MORRIS WATER MAZE Florentina Anindita Christiyanto; Endang Mahati; Noor Wijayahadi; Yora Nindita
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.37788

Abstract

Background: Antioxidants are a group of chemicals that protect biological systems against the potential harmful effects of oxidation processes or its reactions. Kaffir lime peel (Citrus hystrix) contains various potential antioxidants substances those are able to protect neurons from free radical-induced damage. Objective: To evaluate the effect of kaffir lime peel extract (Citrus hystrix) on the spatial memory of mice induced by Scopolamine (SCM). Methods: This research was a true experimental study with a post-test-only controlled group design. Thirty mice were randomly divided into 5 groups. SCM was injected intraperitoneally on day 1-7 and kaffir lime peel extract was given orally on day 2-7, the spatial memory testing of mice using Morris Water Maze on day 8. Data analysis used One-Way ANOVA test (α = 0.05) and continued with Post Hoc LSD test (α = 0.05). Results: The mean spatial memory of K+, K-, P1, P2,P3 were 16,33 ± 7,42; 70,00 ± 32,24; 25,66 ± 24,43; 23,00 ± 19,39; 25,00 ± 19,50 seconds respectively. There were significant differences in spatial memory in P1, P2, dan P3 to the negative control group, but there is no significant differences between treatment grups. Conclusion: Kaffir lime peel extract (Citrus hystrix) can improve the spatial memory of scopolamine-induced dementia (SCM) mice. There is no dose effect relationship between the treatment groups
Effect of Melinjo Seed Extract on GSH Levels of Hyperuricemic Wistar Rats Ardhana Fadhiilah; Endang Mahati; Noor Wijayahadi; Yora Nindita
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 3 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i3.37507

Abstract

Background: Hyperuricemia is a condition where uric acid levels are above normal. The biosynthesis of uric acid by the enzyme xanthine oxidase (XO) produces free radicals that cause oxidative stress. Oxidative stress lowers cellular GSH levels. Gnetum gnemon L. or melinjo seeds contain stilbenoids and flavonoids that can act as natural XO inhibitors. Objective: To study the effect of melinjo seed extract on GSH levels.Methods: This research was a true experimental with pre and post-test controlled group design. Thirty six male wistar rats were randomly divided into 6 groups consisting of a healthy control (KS), negative control (K1), positive control (K2), treatment 1 (P1) extract 250 mg/kgBW, treatment 2 (P2) extract 500 mg/kgBW, treatment 3 (P3) extract 2000 mg/kgBW. Hyperuricemia was induced by the administration of Maggie® block broth and potassium oxonate. Measurement was carried out on the 21st and 35th day of treatment, then analyzed using Paired-Sample T Test, continued with One-Way Anova test and Post Hoc LSD test. Results: Administration of melinjo seed extract at P1, P2, and P3 significantly increased GSH levels (P<0.05) from 1.23±0.10 to 1.55±0.16; 1.22±0.06 to 1.73±0.16; and 1.21±0.08 to 1.88±0.08. There was significant difference between the three doses with a dose of 250 mg/kgBW melinjo seed extract being more effective than allopurinol 90 mg/kgBW. Conclusion: Melinjo seed extract could increase GSH levels with the most effective dose of 250 mg/kgBB.
Co-Authors Ardhana Fadhiilah Endang Mahati Florentina Anindita Christiyanto Yora Nindita