The purpose of this study was to find out how the influence of entrepreneurial knowledge and family environment on the interest in entrepreneurship as an intermediate variable of self-efficacy. The basic population of this study consisted of 114 students after processing the Slovin formula with a standard error of 5%. In this study, a questionnaire was used as a data collection tool. Descriptive analysis, path analysis and Sobel's test were used to analyze the data. The results showed that 1) knowledge of entrepreneurship had a positive and significant effect on the interest in entrepreneurship, 2) the family environment had no positive and significant effect on the interest in entrepreneurship, 3) self-efficacy had a positive and significant effect. about entrepreneurship Interest in entrepreneurship 4) Knowledge of entrepreneurship has a positive and significant effect on self-efficacy 5) Family environment has a positive and significant effect on self-efficacy 6) Knowledge of entrepreneurship has a positive and significant effect on entrepreneurship interest through self-efficacy 7) Family environment has a positive and significant effect significantly to the interest in entrepreneurship through self-efficacy. The conclusions from this study indicate that entrepreneurial competence and family environment have a positive and significant effect on the interest in entrepreneurship through self-efficacy.