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All Journal Jurnal Berkala Epidemiologi Folia Medica Indonesiana
Feriawan Tan
Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Immunology & microbiology Public Health Other

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Clinical Profiles and Il-6 Level Analysis of Critical Covid-19 Patients Receiving Lopinavir-Ritonavir Erwin Astha Triyono; Nancy Margarita Rehatta; Nabilah; Feriawan Tan
Folia Medica Indonesiana Vol. 59 No. 2 (2023): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.602 KB) | DOI: 10.20473/fmi.v59i2.44715

Abstract

Highlights:1. Lymphocyte, procalcitonin, D-dimer and high IL-6 levels in COVID-19 patients are associated with a poor prognosis.2. IL-6 serial measurement for COVID-19 patients may be a potential indicator for evaluating the severity and patient outcome. Abstract The COVID-19 pandemic has affected over 760 million individuals worldwide, resulting in more than 6.8 million reported deaths. Early detection of patient deterioration can assist in predicting outcomes and prioritizing healthcare services based on evidence-based indicators. Interleukin-6 (IL-6) is a cytokine that plays a role in the inflammatory process, making it a potential parameter for assessing a patient's inflammatory state. This study aimed to analyze the characteristics, laboratory profiles, and IL-6 levels of COVID-19 patients. This study used a retrospective cohort study design with medical record data. The characteristics (n=68) and IL-6 levels (n=52) of the patients on the first, third, and sixth days of treatment were recorded consecutively. The mean age of the patients was 49 years, with the majority being male (72%) and the most prevalent comorbidity being hypertension (29%). The average duration of hospitalization was 10.94 days. Shortness of breath was the most commonly reported symptom (45.6%). The medians of neutrophil-lymphocyte ratio, C-reactive protein, procalcitonin, ferritin, and D-dimer were above normal. Significant differences were observed in lymphocytes (p=0.046), procalcitonin (p=0.023), and D-dimer (p=0.000) between survivor and non-survivor patients. Significant dynamic changes in IL-6 levels were observed from the first day to the sixth day (p=0.014) and from the third day to the sixth day (p=0.041). In conclusion, risk stratification, laboratory profiles, and IL-6 levels play a role in assessing the severity and outcomes of COVID-19 patients. 
EARLY DETECTION OF TUBERCULOSIS APPLICATION (E-TIBI): A NEW PARADIGM TO DETECT NEW CASE OF TUBERCULOSIS: Aplikasi Deteksi Dini Tuberkulosis (E-TIBI): Paradigma Baru untuk Menemukan Kasus Baru Tuberkulosis Erwin Astha Triyono; MVS Mahanani; Sulvy Dwi Anggraini; Hafidh Maulana; Wahyu Dian Pratiwi; Christian Yochanan; Feriawan Tan; Lilis Masyfufah
Jurnal Berkala Epidemiologi Vol. 11 No. 3 (2023): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V11I32023.267-276

Abstract

Background: Tuberculosis (TB) is still one of the major health problems in the world, especially in countries with dense populations. Indonesia is listed among the top three countries with the highest burden of tuberculosis worldwide. The low coverage of case detection in Indonesia is one of the reasons for ineffective TB control. Therefore, this disease remains a threat to spread in today’s Indonesian society. Digital technology can be used to increase the effectiveness and efficiency of case detection. This study aims to create a new paradigm for detecting new cases of tuberculosis using a self-assessment website-based application. Methods: This descriptive quantitative research used univariate analysis. Respondents for this research were sampled from all East Java people who filled out the E-TIBI application. Result: In total, there were 4,658 E-TIBI users in East Java, with 20.80% suspected of tuberculosis. The most frequent symptoms found in the respondents were fatigue, cough for > 2 weeks, and weight loss. Discussion: A self-assessment paradigm based on digital technology was applied to the design of this E-TIBI application. From this application, the public can quickly determine whether they or others are suspected of having tuberculosis. This result shows that the whole community can easily access the E-TIBI application for initial tuberculosis screening. Conclusion: Through this application, direct community participation can increase the detection of new cases to support the government and WHO programs in eliminating tuberculosis by 2030.
Co-Authors Christian Yochanan Erwin Astha Triyono Erwin Astha Triyono Hafidh Maulana Lilis Masyfufah MVS Mahanani Nabilah Nancy Margarita Rehatta Sulvy Dwi Anggraini Wahyu Dian Pratiwi