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All Journal Jurnal Kedokteran Syiah Kuala Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Althea Medical Journal Jurnal Berkala Epidemiologi Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Jurnal Media Gizi Indonesia (MGI) The Indonesian Biomedical Journal Journal Of Vocational Health Studies Amerta Nutrition JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Jurnal Pengabdian Masyarakat dalam Kesehatan Indian Journal of Forensic Medicine & Toxicology

Erwin Astha Triyono

Departement Of Internal Medicine, Faculty Of Medicine Airlangga University, Dr. Soetomo Hospital, Surabaya, Indonesia

Author-ID : 508768

Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Medical Audit of the Management of Patients with Sepsis in the Intermediate Care Unit of Department Internal Medicine School of Medicine Airlangga University/Dr. Soetomo Hospital Hadi, Usman; Triyono, Erwin Astha
Indonesian Journal of Tropical and Infectious Disease Vol 1, No 1 (2010)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (335.93 KB)

Sepsis and septic shock is one of the highest causes of death in patients treated in hospitals. Research Objectives: to evaluate the quality of the management of sepsis patients in Intermediate Care Unit, Department of Internal Medicine Dr. Soetomo Hospital Surabaya, Indonesia. This study was a retrospective study to re-evaluate the patient medical record. The number of patients treated: 275 patients, sepsis patients: 80 patients, the number of patients who entered the study 50 patients, 30 (60%) female and 20 (40%) men, most age groups aged 60 -70 years (32%), Mean 54 Median 56. Diagnostic accuracy according to the criteria of sepsis 45 (90%) patients, compliance with taking blood culture 2 (4%) patients, appropriate antibiotic selection 49 (98%) patients, the number of patients who should not be given antibiotics (4 patients), but given the antibiotic is 3 (75%) patients, the number of patients who should be given antibiotics (46 patients) but were not given antibiotics 1 (2%) patient. The reason of patients discharged: 27 had died (54%), 13 cured (26%), not yet recovered 10 (20%). The reason of patients discharged forcibly: to feel recovered 2 (20%), the condition gets worse 3 (30%), no cost 2 (20%), not clear 3 (30%). Patients with sepsis remain a big problem, and it still needs to improve the management of sepsis on existing guidelines.

CORRELATION BETWEEN INTERFERON GAMMA RELEASE ASSAY OF ELISPOT METHOD AND CD4+ T LYMPHOCYTE CELL COUNT IN HIV POSITIVE PATIENTS Ambar, Nabil Salim; Aryati, Aryati; Kusmiati, Tutik; Triyono, Erwin Astha
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 3 (2019)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i3.1416

Introduction. HIV is a virus that can cause AIDS, which affects the immune system and weakens the body function in fighting disease. The primary cells that HIV attacks are CD4+ T lymphocytes. Opportunistic Infections (OIs) are the biggest risk factors of death in HIV patients and occur in CD4+ T cells <200 cells/μL lymphocytes. TB is a disease with a high mortality rate in the world where Indonesia is a TB endemic country with the highest morbidity rates of TB in the world. The most common OI in people with HIV is TB. The number of limitations on Tuberculin Skin Test (TST) is large, thus in vitro T cells test with (Interferon Gamma Release Assay) IGRA is used in diagnosing latent TB. The aim of this study was to determine the correlation between IGRA ELISPOT method and CD4+ T lymphocyte cell count in HIV positive patients.Method. This was an observational analytical study with cross sectional design. The number of samples was 56 HIV positive patients who were treated at the UPIPI Clinic of the Dr Soetomo Surabaya Hospital. The examination of CD4+ T lymphocyte count was perfomed with FACSCalibur and IGRA was examined with T-SPOT.TB. The results were analyzed using Spearman correlation test.Results. CD4 + lymphocyte cell counts based on WHO groupings were as follows: > 500 cells / μL (33.92%), 200-349 cells / μL (25%), 350-499 cells / μL (25%) and <200 cells / μL (16 , 07%). IGRA examination results showed 35.18% positive and 64.81% negative. The grouping of CD4+ T lymphocyte cell counts based on IGRA test results was 27.77% with positive IGRA and 48.14% with negative IGRA. Spearman correlation test between CD4+ T cell lymphocytes with IGRA in HIV positive patients showed r = 0,036 (p = 0,794).Conclusion. There was no correlation between interferon gamma release assay of ELISPOT method and CD4+ T lymphocyte cell count in HIV positive patients.

Pola Penggunaan Levofloxacin pada Pasien HIV dan AIDS di UPIPI RSUD DR. Soetomo Surabaya Pambudi, Rien Esti; Triyono, Erwin Astha; Surdijati, Siti; Jaya, Halim Priyahau
Jurnal Farmasi Sains dan Terapan Vol 5, No 2 (2018)
Publisher : Jurnal Farmasi Sains dan Terapan

HIV is a retrovirus (RNA) that attacks the human immune system. AIDS is a retrovirus disease characterized by immunosuppression which causes opportunistic infectious diseases. Opportunistic infections appear with new forms of infection by other microorganisms or reactivation of latent infections under normal conditions that can be controlled by the immune system so as not to cause manifestations. Opportunistic infections show effects on immunity associated with CD4 cell counts. The therapy used to reduce opportunistic infections is levofloxacin. Based on research, levofloxacin for HIV AIDS patients is often used to reduce opportunistic infections including bacterial pneumonia, tuberculosis and sepsis. This study aims to provide data that includes levofloxacin therapeutic doses, frequency use, old route drugs, prevalence and interaction of qualitative analysis related to medical records in HIV & AIDS patients at UPIPI DR. Soetomo Regional General Hospital Surabaya. The research method used is a retrospective observational study on medical records of patients with HIV & AIDS. Sampling was done by consecutive sampling in the period January 1, 2015 to June 30, 2015. The results obtained from the most relevant types of research, dose, frequency and route were levofloxacin for the treatment of opportunistic infections, especially bacterial pneumonia, tuberculosis, and sepsis. in oral doses and injections at a dose of 500 mg and a frequency of 750 mg 1x1. The use of levofloxacin given to HIV & AIDS patients at UPIPI DR. Surabaya Soetomo Regional General Hospital, related to dosage, route, frequency, interval, and duration of administration is in accordance with existing guidelines.

Pola Penggunaan Ranitidine pada Pasien HIV & AIDS di UPIPI RSUD DR. Soetomo Surabaya Nurohmawati, Weni; Triyono, Erwin Astha; Surdijati, Siti; Jaya, Halim Priyahau
Jurnal Farmasi Sains dan Terapan Vol 4, No 2 (2017)
Publisher : Jurnal Farmasi Sains dan Terapan

HIV is a retrovirus that attacks CD4 lymphocyte cells. AIDS is a retrovirus disease caused by infection with retrovirus HIV-1 or HIV-2 which causes opportunistic diseases, secondary neoplasms and neurological abnormalities. In patients with HIV & AIDS often experience gastrointestinal disorders such as nausea and vomiting caused by side effects of the use of antiretroviral or due to other factors. Ranitidine is an H2 inhibitory receptor that will selectively and reversibly reduce excess gastric acid secretion. In this study ranitidine was used as a stress ulcer prophylaxis in hospitalized patients. This study aims to display ranitidine therapy data including type, dose, route of drug administration, prevalence, duration of use and qualitative analysis of interactions associated with medical record data at UPIPI RSUD Dr. Soetomo Surabaya. The research method used was observational prospectively on patient medical record with HIV & AIDS. Sampling was carried out by consecutive sampling period from November 1, 2016 to December 31, 2016. The results of this study give information that ranitidine was most widely used for stress ulcer prophylaxis therapy in hospitalized patients in UPIPI RSUD Dr. Soetomo Surabaya in a dose of 50mg / 2ml with a frequency of 2x1 while for oral ranitidine with a dose of 150mg / tablet with a frequency of 2x1. The use of ranitidine on HIV & AIDS patients in UPIPI RSUD Dr Soetomo Surabaya, related to dosage, route, frequency, interval, and duration of administration is in accordance with the existing guidelines.

The Effect of Ciprofloxacin Exposure on Ctx-M Gene Pattern of Escherichia Coli Muhammad Amin1, Eddy Bagus Wasito1, Erwin Astha Triyono2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 1 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i1.300

Background: An exposure of ciprofloxacin on Escherichia coli (E.coli) may cause cross-resistance to beta-lactam groups. The researchers obtained that ciprofloxacin, aminoglycoside, cotrimoxazole and second generation of cephalosporins were the risk factors for infection caused by Extended-Spectrum ?-Lactamases (ESBL)-producing bacteria. Exposure of ciprofloxacin to E.coli causes resistance of cefotaxime and produces ESBL which is genotypically evidenced by the presence of CTX-M.Objective: To know the effect of ciprofloxacin exposure on CTX-M gene pattern of E. coli.Method: A total of 30 E.coli isolates were exposed to ciprofloxacin for 14 days with the Kirby-Bauer antibiotic disc diffusion method. ESBL confirmatory test and Modified Double Disk Susceptibility Test (MDDST) method was used the antibiotic disc and continued electrophoresis using Polymerase Chain Reaction (PCR). The data analysis used the chi-square statistic test with ? = 0.05.Results: In the PCR examination, 10.00% of ESBL isolates were obtained to have CTX-M-15 gene, and 33.00% of non-ESBL E.coli isolates having CTX-M-15 gene. While 10.00% of E.coli ESBL isolates and 53.30% non-ESBL did not have CTX-M-15 genes. There was no significant difference between ciprofloxacin exposure and the presence of CTX-M-15 gene (p = 0.290).Conclusion: Most of the E.coli isolates had CTX-M-15 gene after the exposure. There was no difference in ciprofloxacin exposure to the presence of CTX-M-15 genes of E. coli.

Correlation of CD4 and Distal Sensory Polyneuropathy in HivAids Patients Desti Ariani Kistanti1, Paulus Sugianto1, Erwin Astha Triyono2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3134

Infection of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) has developed into one of the most important health problems in the world. Distal sensory polyneuropathy (DSP) is the most common complication of peripheral neuropathy in HIV-AIDS. Risk factors associated with DSP are elderly, stage of HIV disease, (cluster differential-4) CD4 count, and high plasma viral load in plasma. To analyze the relationship between CD4 and distal sensory polyneuropathy in HIV-AIDS patients. Subjects of the study examined the degree of severity of distal sensory polyneuropathy by examination of the Surface Nerve Surgical Nerve Speed, then divided into case group and control group. After that, the subjects performed a CD4 count examination. Data analysis using chi-square test. Most body mass index (BMI) subjects did not experience malnutrition by 35% of case group and 35% control group (p = 1.000). Most subjects aged ?40 years were 37.5% of case group and 25% control group (p = 0.102). Analysis of CD4 relation with Speed of Nerve Surgical Nerve Survival was obtained p = 0.038. There was a significant relationship between CD4 and Distal Sensory Polyneuropathy in HIV-AIDS patients. While age and malnutrition were not found a significant relationship with distal sensory polyneuropathy.

Diagnostic test of Brief Peripheral Neuropathy Screen as Distal Sensory Polyneuropathy-HIV Diagnostic Tool Joko Rudyono1, Mudjiani Basuki1, Erwin Astha Triyono2
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 2 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i2.3169

Distal sensory polyneuropathy (DSP) is the most common human immunodeficiency virus (HIV)-associated peripheral neuropathy with a prevalence of 30-67%. Brief peripheral neuropathy screen (BPNS) examination is a non-invasive, fast, cheap, easy-to-do diagnostic method, and one of the clinical tools that can be used to diagnose HIV-DSP. This study to assess the BPNS diagnostic test as a DSP diagnostic tool in HIV patients. The cross-sectional study was conducted on HIV patients that allegedly having DSP. All subjects were examined by BPNS and nerve conduction study (NCS), then the results were analyzed by chi-square test of a 2x2 Table. There were 42 subjects enrolled in this study. The mean patients were 38.88±8.62 years and most of the male patients were 24 subjects (57.14%). Most of the patients had high school education by 20 (47.61%) subjects and did not take anti-retroviral (ARV) by 18 (42.85%) subjects. Most of the research subjects conducted BPNS disturbed examination by 27 (64.28%) subjects and examination of NCS obtained positive DSP by 30 (71.4%) subjects. The obtained sensitivity of 83% BPNS, 83% specificity, 93% positive predictive value, the negative predictive value of 67%, a positive likelihood ratio of 5.00, and a negative likelihood ratio of 0.20. BPNS examination with 83% sensitivity and 83% specificity can be used as a DSP diagnostic tool in HIV patients.

Gigantomastia Bilateral Induced Efavirenz: A Case Report Amos Pongbulaan; Erwin Astha Triyono
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15437

The prognosis of HIV-infection has improved dramatically since the introduction of Highly Active Antiretroviral Therapy (HAART). With the need for a lifelong treatment, the longterm side effect of antiretroviral agents is an emergent issue of concern. Gigantomastia is a rare condition characterized by excessive breast growth. It may occur spontaneously, during puberty or pregnancy, or while taking certain medications. HAART medications which probably associated with gigantomastia is efavirenz. A 25-yearold woman with HIV-infection who developed bilateral gigantomastia while receiving efavirenz-based HAART regimens. The diagnosis was made after other possible causes of disease-induced gigantomastia were exclude and confirmed by mammography. Surgical treatment has been considered after failure of medical treatment. Although it is rare, physicians should be aware so that a timely diagnosis can be made. In most cases, only conservative treatment is sufficient, but in severe cases surgical intervention might be required.

Knowledge and Attitude on Human Immunodeficiency Virus among Migrant Worker Candidates in East Java, Indonesia Faiz Murfid Gunawan; Pudji Lestari; Erwin Astha Triyono
Althea Medical Journal Vol 7, No 3 (2020)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v7n3.1824

Background: In 2018, East Java province becomes the province with the highest number of Human Immunodeficiency Virus (HIV) cases in Indonesia with an incidence of more than 8,000 cases. This province has various groups of Indonesian Migrant Workers (Tenaga Kerja Indonesia, TKI) working in various sectors in different countries, making them prone to HIV infection. This study aimed to determine the level of knowledge and attitude towards HIV and Acquired Immune Deficiency Syndrome (AIDS) among migrant worker candidates in East Java.Methods: This was a cross-sectional descriptive study conducted in August 2018 in the Provincial Manpower and Transmigration Office of East Java, Indonesia. The knowledge and attitude towards HIV disease were assessed using a self-validated questionnaire distributed to 104 migrant worker candidates as the subjects of this study.Results: Eighty-nine percent of the subjects had good knowledge, while 98% of them had good attitudes towards HIV disease. Furthermore, 86% had good attitudes toward HIV transmission. However, no correlation was observed between the subjects’ level of knowledge and their attitude (p=0.334).Conclusions: In general, the level of knowledge and attitudes of migrant worker candidates in East Java towards HIV disease is good. Nevertheless, more knowledge and education on healthy behavior need to be envisaged for this group.

PROFIL PASIEN ULKUS GENITAL DI UNIT RAWAT JALAN KULIT DAN KELAMIN RSUD DR. SOETOMO SURABAYA Senda Sulvain Rahmaningrat; Afif Nurul Hidayati; Erwin Astha Triyono; Dwi Aprilawati
Jurnal Kedokteran Syiah Kuala Vol 19, No 2 (2019): Volume 19 Nomor 2 Agustus 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v19i2.18059

Abstrak. Latar Belakang: Penyakit Ulkus Genital meningkatkan risiko tertularnya HIV. Di Indonesia, belum ada data pasti prevalensi pasien Ulkus Genital, juga di RSUD Dr. Soetomo Surabaya. Tujuan: Mengevaluasi profil pasien Ulkus Genital di Unit Rawat Kulit dan Kelamin RSUD Dr. Soetomo Surabaya.Metode: Penelitian ini merupakan jenis penelitian deskriptif retrospektif dengan data sekunder. Populasi penelitian adalah semua rekam medik pasien dengan Ulkus Genital yang dirawat di Unit Rawat Jalan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya tahun 2016, 2017, dan 2018. Sampel diambil menggunakan purposive sampling tanpa eksklusi. Hasil : Ditemukan 36 sampel pasien dengan Ulkus Genital selama tiga tahun dengan distribusi usia antara 13 sampai 64 tahun. Usia yang paling mendominasi adalah kelompok usia 20 – 24 tahun sebanyak 30,56%. Sebagian besar sampel berjenis kelamin perempuan, sudah kawin, dan hanya berhubungan dengan lawan jenis. Diagnosis utama pasien Ulkus Genital paling banyak adalah Herpesviral infection of genitalia and urogenital tract. Tipe Ulkus Genital terbanyak adalah Ulkus Herpes dan pemeriksaan penunjang terbanyak yang dilakukan adalah Pemeriksaan Gram. Outcome/Hasil Terapi kebanyakan menunjukkan perkembangan yang baik kearah kesembuhan. Sebagian besar pasien Ulkus Genital datang tanpa kelainan penyerta. Kesimpulan: Mayoritas pasien sebanyak 53,8% dengan Ulkus Genital mengidap Herpes Simplek Primer. Kata Kunci: Ulkus Genital, Herpes Simplek PrimerAbstract. Background: Genital ulcer disease increases the risk of contracting HIV. In Indonesia, there is no exact data on the prevalence of Genital Ulcer patients, also in Dr. Soetomo Surabaya.Purpose: Evaluating the profile of genital ulcer patients in outpatient care unit Department of Dermatology and Venereology Dr. Soetomo General Academic Hospital.Methods: This is a retrospective descriptive reseach with secondary data. The study population was all medical records of patients with genital ulcers who were treated in the Department of Dermatology and Venereology Dr. Soetomo General Academic Hospital in 2016, 2017 and 2018. Samples were taken using purposive sampling without exclusion.Results: There were 36 samples of patients with genital ulcers for three years with age distribution between 13 to 64 years. The most dominant age group is in the age group of 20-24 years by 30.56%. Most of the samples were female, married, and only related to the opposite sex. The main diagnosis of most genital ulcer patients is Herpesviral infection of genitalia and urogenital tract. The most common type of genital ulcer is herpes ulcer and the most investigation is carried out is Gram examination. Outcome results mostly show good progress toward healing. Most patients with genital ulcer come without comorbidities.Conclusion: The majority of patients were 53.8% with genital ulcer suffering from Herpesviral infection of genitalia and urogenital tract.Keywords: Genital Ulcer, Herpesviral infection

Co-Authors Abu Rohiman Afif Nurul Hidayati Ambar, Nabil Salim Amos Pongbulaan Anak Agung Ayu Niti Wedayani Anindita Abigail Arthur Pohan Kawilarang Aryati Aryati Bambang Wiryanto Bramantono - Brian Eka Rahman Budiono Budiono Christian Yochanan Christina Avanti Cita Rosita Sigit Prakoeswa Djoni Susanto Dwi Aprilawati Dwi Murtiastutik Eddy Bagus Wasito Endang Retnowati Endang Retnowati Endang Wahyu Fitriani Erika Marfiani Erna Kristin Eti Nurwening Sholikhah Eva Lydiawati Faiz Murfid Gunawan Feriawan Tan Feriawan Tan Firdausa, Sarah Firdausiyah Firdausiyah Hafidh Maulana Harianah Harianah Hermi Indita Heru Prasetyo I Made Sila Darmana Intan Putri Risky Amalia Iskandar Zulkarnain Ivan Hoesada James Hutagalung Jaya, Halim Priyahau JS. Hutagalung Kusmiati, Tutik Lilis Masyfufah Linda Astari M Vitanata M. Yulianto Listiawan ManikRetno Wahyunitisari Masyfufah, Lilis Muhammad Amin Musofa Rusli MVS Mahanani Nurohmawati, Weni Oryza Dwi Nanda Pambudi, Rien Esti Pauline Hadisiswoyo Pudji Lestari R. Heru Prasetyo Rahmadewi Rahmadewi Rimbun Rimbun Sajuni Widjaja Senda Sulvain Rahmaningrat Siti Rahayu Nadhiroh Siti Surdijati, Siti Sulistiawati Sulistiawati Sulvy Dwi Anggraini Syahru Ramadhaan Unzila Tripudi Asmarawati Umiastuti, Pirlina Usman Hadi Usman Hadi Wahyu Dian Pratiwi

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